Evaluation of the Therapeutic Effects of the Hydroethanolic Extract of Portulaca oleracea on Surgical-Induced Peritoneal Adhesion

Objective. Peritoneal adhesion (PA) is an abnormal connective tissue that usually occurs between tissues adjacent to damaged organs during processes such as surgery. In this study, the anti-inflammatory and antioxidant effects of Portulaca oleracea (PO) were investigated against postoperative-induce...

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Published in:	Mediators of inflammation Vol. 2021; pp. 8437753 - 18
Main Authors:	Jaafari, Ali, Baradaran Rahimi, Vafa, Vahdati-Mashhadian, Nasser, Yahyazadeh, Roghayeh, Ebrahimzadeh-Bideskan, Alireza, Hasanpour, Maede, Iranshahi, Mehrdad, Ehtiati, Sajjad, Rajabi, Hamed, Mahdinezhad, Mohammadreza, Rakhshandeh, Hassan, Askari, Vahid Reza
Format:	Journal Article
Language:	English
Published:	United States Hindawi 2021 John Wiley & Sons, Inc Hindawi Limited
Subjects:	Abdomen Adhesion Administration, Oral Amino acids Angiogenesis Animals Anti-Inflammatory Agents - chemistry Antioxidants Antioxidants - chemistry Biomarkers - metabolism Cardiovascular disease Cell Adhesion Chromatography Connective tissues Cytokines - metabolism Drug dosages Ethanol Ethanol - chemistry Ethics Fibrosis Glutathione Health aspects Herbal medicine IL-1β Immunoassay Inflammation Interleukin 10 Interleukin 6 Interleukins Laboratory animals Laparotomy Male Malondialdehyde Medical research Neovascularization, Pathologic Nonsteroidal anti-inflammatory drugs Oral administration Oxidants - chemistry Oxidative Stress Peritoneal Lavage Peritoneum Peritoneum - pathology Phytotherapy Plant Extracts - therapeutic use Portulaca - drug effects Portulaca oleracea Postoperative Period Rats Rats, Wistar Surgery Tissue Adhesions - drug therapy Transforming growth factor-b1 Transforming growth factors Tumor necrosis factor-TNF Tumor necrosis factor-α Tumors Vascular endothelial growth factor Iran United States > US
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Summary:	Objective. Peritoneal adhesion (PA) is an abnormal connective tissue that usually occurs between tissues adjacent to damaged organs during processes such as surgery. In this study, the anti-inflammatory and antioxidant effects of Portulaca oleracea (PO) were investigated against postoperative-induced peritoneal adhesion. Methods. Thirty healthy male Wistar rats (220±20 g, 6-8 weeks) were randomly divided into four groups: (1) normal, (2) control (induced peritoneal adhesion), and (3) and (4) PO extracts (induced peritoneal adhesion and received 100 or 300 mg/kg/day of PO extract for seven days). Finally, macroscopic and microscopic examinations were performed using different scoring systems and immunoassays in the peritoneal lavage fluid. Results. We found that the levels of adhesion scores and interleukin- (IL-) 1β, IL-6, IL-10, tumour necrosis factor- (TNF-) α, transforming growth factor- (TGF-) β1, vascular endothelial growth factor (VEGF), and malondialdehyde (MDA) were increased in the control group. However, PO extract (100 and 300 mg/kg) notably reduced inflammatory (IL-1β, IL-6, and TNF-α), fibrosis (TGF-β1), angiogenesis (VEGF), and oxidative (MDA) factors, while increased anti-inflammatory cytokine IL-10, antioxidant factor glutathione (GSH), compared to the control group. Conclusion. Oral administration of PO improved postoperational-induced PA by alleviating the oxidative factors, fibrosis, inflammatory cytokines, angiogenesis biomarkers, and stimulating antioxidative factors. Hence, PO can be considered a potential herbal medicine to manage postoperative PA. However, further clinical studies are required to approve the effectiveness of PO.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Academic Editor: Matilde Otero-Losada
ISSN:	0962-9351 1466-1861
DOI:	10.1155/2021/8437753