Search Results - "Mahdi, Wael A"
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Application of quality-by-design for adopting an environmentally green fluorogenic determination of benoxinate hydrochloride in eye drops and artificial aqueous humour
Published in Scientific reports (26-05-2023)“…Herein, a sensitive and selective spectrofluorimetric method has been developed for the determination of the ocular local anesthetic benoxinate hydrochloride…”
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Neuroprotectant Effects of Hibiscetin in 3-Nitropropionic Acid-Induced Huntington's Disease via Subsiding Oxidative Stress and Modulating Monoamine Neurotransmitters in Rats Brain
Published in Molecules (Basel, Switzerland) (01-02-2023)“…Previously reported data suggest that hibiscetin, isolated from , contains delphinidin-3-sambubioside and cyanidin-3-sambubioside including anthocyanidins and…”
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3
Solubilization and Thermodynamic Analysis of Isotretinoin in Eleven Different Green Solvents at Different Temperatures
Published in Materials (21-11-2022)“…The solubilization and thermodynamic analysis of isotretinoin (ITN) in eleven distinct green solvents, such as water, methyl alcohol (MeOH), ethyl alcohol…”
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Recent Progress in Lipid Nanoparticles for Cancer Theranostics: Opportunity and Challenges
Published in Pharmaceutics (07-06-2021)“…Cancer is one of the major leading causes of mortality in the world. The implication of nanotherapeutics in cancer has garnered splendid attention owing to…”
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Formulation of Chitosan-Coated Apigenin Bilosomes: In Vitro Characterization, Antimicrobial and Cytotoxicity Assessment
Published in Polymers (25-02-2022)“…We prepared apigenin (APG)-loaded bilosomes (BLs) and evaluated them for vesicle size, zeta-potential and encapsulation efficiency. The formulations were…”
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Formulation and Optimization of Butenafine-Loaded Topical Nano Lipid Carrier-Based Gel: Characterization, Irritation Study, and Anti-Fungal Activity
Published in Pharmaceutics (16-07-2021)“…The present study aims to prepare and optimize butenafine hydrochloride NLCs formulation using solid and liquid lipid. The optimized selected BF-NLCopt was…”
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Solubility and Thermodynamic Properties of Febuxostat in Various (PEG 400 + Water) Mixtures
Published in Materials (01-10-2022)“…The solubility of the poorly soluble medicine febuxostat (FXT) (3) in various {polyethylene glycol 400 (PEG 400) (1) + water (H2O) (2)} mixtures has been…”
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Two Versatile Pencil Graphite-Polymer Sensor Electrodes Coupled with Potentiometry and Potentiometric Titration Methods: Profiling Determinations of Vitamin V in Tablets and Urine Samples
Published in Sensors (Basel, Switzerland) (24-11-2022)“…Herein, we developed a new pencil graphite ion-selective electrode strategy for the broadly used erectile dysfunction medication, sildenafil citrate (SC,…”
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Identification of Potential Antitubulin Agents with Anticancer Assets from a Series of Imidazo[1,2- a ]quinoxaline Derivatives: In Silico and In Vitro Approaches
Published in Molecules (Basel, Switzerland) (13-01-2023)“…Computer-aided drug design is a powerful and promising tool for drug design and development, with a reduced cost and time. In the current study, we rationally…”
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Formulation of silymarin surface modified vesicles: In vitro characterization to cell viability assessment
Published in Saudi pharmaceutical journal (01-06-2024)“…Silymarin (SLR) is a poorly water-soluble bioactive compound with a wide range of therapeutic activities. Nanosized silymarin vesicles (F1–F6) were prepared by…”
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Citrate-Capped AuNP Fabrication, Characterization and Comparison with Commercially Produced Nanoparticles
Published in Crystals (Basel) (01-12-2022)“…Gold nanoparticles (AuNPs) were synthesized using citrate reduction, also known as the Turkevich method. The AuNPs were compared with the commercially…”
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Phytoconstituents of Butterbur (P. japonicus), their metabolic pathway and ability to modulate bone morphogenic protein (BMP) signaling
Published in Journal of plant interactions (31-12-2023)“…A library of natural sesquiterpene and phenolic compounds from Petasites japonicus are being investigated through different computational techniques to study…”
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Novel Natrosol/Pectin-co-poly (acrylate) based pH-responsive polymeric carrier system for controlled delivery of Tapentadol Hydrochloride
Published in Saudi pharmaceutical journal (01-08-2023)“…This study aimed to create a controlled delivery system for Tapentadol Hydrochloride by developing interpenetrating networks (IPNs) of Natrosol-Pectin…”
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Formulation of Multicomponent Chrysin-Hydroxy Propyl β Cyclodextrin-Poloxamer Inclusion Complex Using Spray Dry Method: Physicochemical Characterization to Cell Viability Assessment
Published in Pharmaceuticals (Basel, Switzerland) (01-12-2022)“…The work aimed to enhance chrysin (CHR) water solubility, dissolution, and in vitro antibacterial as well as cell viability. Chrysin binary, as well as ternary…”
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Optimisation of a Greener-Approach for the Synthesis of Cyclodextrin-Based Nanosponges for the Solubility Enhancement of Domperidone, a BCS Class II Drug
Published in Pharmaceuticals (Basel, Switzerland) (01-04-2023)“…BCS class II molecules suffer from low oral bioavailability because of their poor permeability and sub-optimal aqueous solubility. One of the approaches to…”
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Cytotoxic and Pro-Apoptotic Effects of a Sub-Toxic Concentration of Fluvastatin on OVCAR3 Ovarian Cancer Cells After its Optimized Formulation to Melittin Nano-Conjugates
Published in Frontiers in pharmacology (03-02-2021)“…Fluvastatin (FLV) is a hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor often used to lower total and low-density lipoprotein (LDL) cholesterol…”
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GC-MS Analysis, Phytochemical Screening, and Antibacterial Activity of Cerana indica Propolis from Kashmir Region
Published in Separations (01-11-2022)“…Propolis is a resinous compound produced by honey bees. It contains bioactive molecules that possess a wide range of biological functions. The chemical…”
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Development, Optimization and Evaluation of 2-Methoxy-Estradiol Loaded Nanocarrier for Prostate Cancer
Published in Frontiers in pharmacology (16-07-2021)“…The therapeutic efficacy of antineoplastic agents possessing a selective target to the nucleus of the cancer cells could be enhanced through novel formulation…”
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A Greener Stability-Indicating High-Performance Thin-Layer Chromatography Approach for the Estimation of Topiramate
Published in Materials (25-02-2022)“…Despite various reported analytical methods for topiramate (TPM) analysis, greener analytical approaches are scarce in literature. As a consequence, the…”
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A Novel Approach for the Availability and Ocular Delivery of Tenoxicam Potassium: Synthesis, Characterization, and In Vivo Application
Published in AAPS PharmSciTech (26-01-2023)“…Tenoxicam (TX) is a non-steroidal anti-inflammatory agent that can be used to control pain in various ophthalmic lesions like cataracts, refractive surgery,…”
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