Search Results - "Mahdi, Jasia"

A Multispecialty Pediatric Neurovascular Conference: A Model for Interdisciplinary Management of Complex Disease by Ladner, Travis R., BA, Mahdi, Jasia, BA, BS, Attia, Albert, MD, Froehler, Michael T., MD, PhD, Le, Truc M., MD, Lorinc, Amanda N., MD, Mocco, J., MD, MS, Naftel, Robert P., MD, Newton, Allen T., PhD, Pruthi, Sumit, MD, Tenenholz, Todd, MD, PhD, Vance, E. Haley, DNP, Wushensky, Curtis A., MD, Wellons, John C., MD, MSPH, Jordan, Lori C., MD, PhD

“…Abstract Introduction In 2013, our institution established a multidisciplinary pediatric neurovascular conference for coordination of care. Here, we review our…”
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GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas by Majzner, Robbie G., Ramakrishna, Sneha, Yeom, Kristen W., Patel, Shabnum, Chinnasamy, Harshini, Schultz, Liora M., Richards, Rebecca M., Jiang, Li, Barsan, Valentin, Mancusi, Rebecca, Geraghty, Anna C., Good, Zinaida, Mochizuki, Aaron Y., Gillespie, Shawn M., Toland, Angus Martin Shaw, Mahdi, Jasia, Reschke, Agnes, Nie, Esther H., Chau, Isabelle J., Rotiroti, Maria Caterina, Mount, Christopher W., Baggott, Christina, Mavroukakis, Sharon, Egeler, Emily, Moon, Jennifer, Erickson, Courtney, Green, Sean, Kunicki, Michael, Fujimoto, Michelle, Ehlinger, Zach, Reynolds, Warren, Kurra, Sreevidya, Warren, Katherine E., Prabhu, Snehit, Vogel, Hannes, Rasmussen, Lindsey, Cornell, Timothy T., Partap, Sonia, Fisher, Paul G., Campen, Cynthia J., Filbin, Mariella G., Grant, Gerald, Sahaf, Bita, Davis, Kara L., Feldman, Steven A., Mackall, Crystal L., Monje, Michelle

“…Diffuse intrinsic pontine glioma (DIPG) and other H3K27M-mutated diffuse midline gliomas (DMGs) are universally lethal paediatric tumours of the central…”
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NCOG-46. CHROMOSOMAL LOSSES CORRELATE WITH POOR OVERALL SURVIVAL IN H3K27M-ALTERED DIFFUSE MIDLINE GLIOMAS by Steven Leal-Ekman, J, Nguyen, Thien, Campen, Cynthia, Ryan, Katherine, Wheeler, Joshua, Mahdi, Jasia, Monje, Michelle, Partap, Sonia, Prolo, Laura

“…Abstract BACKGROUND H3K27M-altered diffuse midline gliomas (DMG) have poor outcomes with limited biomarkers to predict overall survival. Stratification based…”
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Tumor inflammation-associated neurotoxicity by Mahdi, Jasia, Dietrich, Jorg, Straathof, Karin, Roddie, Claire, Scott, Brian J., Davidson, Tom Belle, Prolo, Laura M., Batchelor, Tracy T., Campen, Cynthia J., Davis, Kara L., Gust, Juliane, Lim, Michael, Majzner, Robbie G., Park, Julie R., Partap, Sonia, Ramakrishna, Sneha, Richards, Rebecca, Schultz, Liora, Vitanza, Nicholas A., Wang, Leo D., Mackall, Crystal L., Monje, Michelle

“…Cancer immunotherapies have unique toxicities. Establishment of grading scales and standardized grade-based treatment algorithms for toxicity syndromes can…”
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Nonoptic pathway tumors in children with neurofibromatosis type 1 by Mahdi, Jasia, Goyal, Manu S., Griffith, Jennifer, Morris, Stephanie M., Gutmann, David H.

“…OBJECTIVETo define the radiologic features and natural history of nonoptic pathway tumors (non-OPTs) in children with neurofibromatosis type 1 (NF1). METHODSWe…”
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Pediatric Acute Stroke Protocol Activation in a Children’s Hospital Emergency Department by Ladner, Travis R, Mahdi, Jasia, Gindville, Melissa C, Gordon, Angela, Harris, Zena Leah, Crossman, Kristen, Pruthi, Sumit, Abramo, Thomas J, Jordan, Lori C

“…BACKGROUND AND PURPOSE—Pediatric acute stroke teams are a new phenomenon. We sought to characterize the final diagnoses of children with brain attacks in the…”
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A multi-institutional study of brainstem gliomas in children with neurofibromatosis type 1 by Mahdi, Jasia, Shah, Amish C, Sato, Aimee, Morris, Stephanie M, McKinstry, Robert C, Listernick, Robert, Packer, Roger J, Fisher, Michael J, Gutmann, David H

“…OBJECTIVE:To define the clinical and radiologic features of brainstem gliomas (BSGs) in children with neurofibromatosis type 1 (NF1). METHODS:We performed a…”
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Stroke Mimics Are Not Benign in Immunocompromised Children by Mahdi, Jasia, Bach, Alicia, Smith, Alyssa E., Tomko, Stuart R., Fields, Melanie E., Griffith, Jennifer L., Morris, Stephanie M., Guerriero, Réjean M., Noetzel, Michael J., Guilliams, Kristin P., Agner, Shannon C.

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IMMU-07. “STROKE MIMICS” ARE NOT BENIGN IN IMMUNOCOMPROMISED CHILDREN by Mahdi, Jasia, Bach, Alicia, Smith, Alyssa, Tomko, Stuart, Fields, Melanie, Griffith, Jennifer, Morris, Stephanie, Guerriero, Rejean, Noetzel, Michael, Guilliams, Kristin, Agner, Shannon

“…Abstract Objective To determine the clinical variances between strokes and stroke mimics in a pediatric immunocompromised population that consists of children…”
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Stroke Mimics Are Not Benign in Immunocompromised Children by Mahdi, Jasia, Bach, Alicia, Smith, Alyssa E., Tomko, Stuart R., Fields, Melanie E., Griffith, Jennifer L., Morris, Stephanie M., Guerriero, Réjean M., Noetzel, Michael J., Guilliams, Kristin P., Agner, Shannon C.

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IMMU-60. MYELOID POPULATIONS MODULATE GD2 CAR T CELL ACTIVITY IN DIFFUSE MIDLINE GLIOMA by Ramakrishna, Sneha, Geraghty, Anna, Good, Zinaida, Desai, Moksha, Mancusi, Rebecca, Mahdi, Jasia, Song, Kun Wei, Ehlinger, Zachary, Chen, Yiyun, Hamilton, Mark, Rietberg, Skyler, Majzner, Robbie, Schultz, Liora, Richards, Becky, Kamens, Jennifer, Barsan, Vali, Campen, Cynthia, Partap, Sonia, Moon, Jennifer, Baggott, Christina, Kunick, Michael, Fujimoto, Michelle, Li, Amy, Jariwala, Sneha, Mavroukakis, Sharon, Egeler, Emily, Jacobs, Ashley, Erickson, Courtney, Prabhu, Snehit, Davis, Kara, Feldman, Steven, Sahaf, Bita, Mackall, Crystal, Monje, Michelle

“…Abstract H3K27M-mutated diffuse midline gliomas (DMGs) are universally lethal cancers in children and young adults. Our team previously demonstrated efficacy…”
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Intravenous and intracranial GD2-CAR T cells for H3K27M+ diffuse midline gliomas by Monje, Michelle, Mahdi, Jasia, Majzner, Robbie, Yeom, Kristen W., Schultz, Liora M., Richards, Rebecca M., Barsan, Valentin, Song, Kun-Wei, Kamens, Jen, Baggott, Christina, Kunicki, Michael, Rietberg, Skyler P., Lim, Alexandria Sung, Reschke, Agnes, Mavroukakis, Sharon, Egeler, Emily, Moon, Jennifer, Patel, Shabnum, Chinnasamy, Harshini, Erickson, Courtney, Jacobs, Ashley, Duh, Allison K., Tunuguntla, Ramya, Klysz, Dorota Danuta, Fowler, Carley, Green, Sean, Beebe, Barbara, Carr, Casey, Fujimoto, Michelle, Brown, Annie Kathleen, Petersen, Ann-Louise G., McIntyre, Catherine, Siddiqui, Aman, Lepori-Bui, Nadia, Villar, Katlin, Pham, Kymhuynh, Bove, Rachel, Musa, Eric, Reynolds, Warren D., Kuo, Adam, Prabhu, Snehit, Rasmussen, Lindsey, Cornell, Timothy T., Partap, Sonia, Fisher, Paul G., Campen, Cynthia J., Grant, Gerald, Prolo, Laura, Ye, Xiaobu, Sahaf, Bita, Davis, Kara L., Feldman, Steven A., Ramakrishna, Sneha, Mackall, Crystal

“…H3K27M-mutant diffuse midline gliomas (DMGs) express high levels of the disialoganglioside GD2 (ref. 1). Chimeric antigen receptor-modified T cells targeting…”
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IMMU-05. TUMOR INFLAMMATION-ASSOCIATED NEUROTOXICITY (TIAN): A TOXICITY SYNDROME IN PATIENTS TREATED WITH IMMUNOTHERAPY FOR CENTRAL NERVOUS SYSTEM TUMORS by Mahdi, Jasia, Dietrich, Jorg, Straathof, Karin, Roddie, Claire, Scott, Brian, Davidson, Tom Belle, Prolo, Laura, Batchelor, Tracy, Campen, Cynthia, Davis, Kara, Gust, Juliane, Lim, Michael, Majzner, Robbie, Park, Julie, Partap, Sonia, Ramakrishna, Sneha, Richards, Rebecca, Schultz, Liora, Vitanza, Nicholas, Wang, Leo, Mackall, Crystal, Monje, Michelle

“…Abstract Immunotherapies have transformed the therapeutic landscape for various cancer indications; currently several preclinical and clinical studies are…”
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Abstract CT031: GD2 CAR T cells mediate clinical activity and manageable toxicity in children and young adults with DIPG and H3K27M-mutated diffuse midline gliomas by Majzner, Robbie G., Ramakrishna, Sneha, Mochizuki, Aaron, Patel, Shabnum, Chinnasamy, Harshini, Yeom, Kristen, Schultz, Liora, Richards, Rebecca, Campen, Cynthia, Reschke, Agnes, Mahdi, Jasia, Toland, Angus Martin Shaw, Baggott, Christina, Mavroukakis, Sharon, Egeler, Emily, Moon, Jennifer, Landrum, Kayla, Erickson, Courtney, Rasmussen, Lindsey, Barsan, Valentin, Tamaresis, John S., Marcy, Anne Cunniffe, Kunicki, Michael, Fujimoto, Michelle, Ehlinger, Zach, Kurra, Sreevidya, Cornell, Timothy, Partap, Sonia, Fisher, Paul, Grant, Gerald, Vogel, Hannes, Sahaf, Bita, Davis, Kara, Feldman, Steven, Mackall, Crystal L., Monje, Michelle

“…Abstract Background: Diffuse intrinsic pontine glioma (DIPG) and other H3K27M-mutated diffuse midline gliomas (DMGs) are universally lethal central nervous…”
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DIPG-47. SEQUENTIAL INTRAVENOUS AND INTRACEREBROVENTRICULAR GD2-CAR T-CELL THERAPY FOR H3K27M-MUTATED DIFFUSE MIDLINE GLIOMAS by Monje, Michelle, Mahdi, Jasia, Majzner, Robbie G, Yeom, Kristen, Schultz, Liora M, Richards, Rebecca, Barsan, Valentin, Song, Kun-Wei, Kamens, Jennifer, Baggott, Christina, Kunicki, Michael, Lim, Alexandria Sung, Reschke, Agnes, Mavroukakis, Sharon, Egeler, Emily, Moon, Jennifer, Patel, Shabnum, Chinnasamy, Harshini, Erickson, Courtney, Jacobs, Ashley, Duh, Allison K, Rietberg, Skyler P, Tunuguntla, Ramya, Klysz, Dorota Danuta, Fowler, Carley, Green, Sean, Beebe, Barbara, Carr, Casey, Fujimoto, Michelle, Brown, Annie Kathleen, Peterson, Ann-Louise G, McIntyre, Catherine, Siddiqui, Aman, Lepori-Bui, Nadia, Villar, Katlin, Pham, Kymhuynh, Bove, Rachel, Musa, Eric, Reynolds, Warren, Kuo, Adam, Prabhu, Snehit, Rasmussen, Lindsey, Cornell, Timothy T, Partap, Soni, Fisher, Paul G, Campen, Cynthia J, Grant, Gerald, Prolo, Laura, Ye, Xiaobu, Sahaf, Bita, Davis, Kara L, Feldman, Steven A, Ramakrishna, Sneha, Mackall, Crystal L

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DIPG-15. Major tumor regressions in H3K27M-mutated diffuse midline glioma (DMG) following sequential intravenous (IV) and intracerebroventricular (ICV) delivery of GD2-CAR T-cells by Monje, Michelle, Majzner, Robbie, Mahdi, Jasia, Ramakrishna, Sneha, Patel, Shabnum, Chinnasamy, Harshini, Yeom, Kristen, Schultz, Liora, Barsan, Valentin, Richards, Rebecca, Campen, Cynthia, Reschke, Agnes, Toland, Angus Martin, Baggott, Christina, Mavroukakis, Sharon, Egeler, Emily, Moon, Jennifer, Jacobs, Ashley, Yamabe-Kwong, Karen, Rasmussen, Lindsey, Nie, Esther, Green, Sean, Kunicki, Michael, Fujimoto, Michele, Ehlinger, Zach, Reynolds, Warren, Prabhu, Snehit, Warren, Katherine E, Cornell, Tim, Partap, Sonia, Fisher, Paul, Grant, Gerald, Vogel, Hannes, Sahaf, Bita, Davis, Kara, Feldman, Steven, Mackall, Crystal

“…Abstract BACKGROUND: H3K27M-mutated DMGs express high levels of the disialoganglioside GD2 and GD2-CAR T-cells (GD2-CART) regress DMG in preclinical models…”
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Abstract T P360: Pediatric Acute Stroke Protocol Activation in a Children’s Hospital Emergency Department by Ladner, Travis R, Mahdi, Jasia, Harris, Z L, Crossman, Kristen, Abramo, Thomas, Jordan, Lori C

“…Abstract only Introduction: Many children’s hospitals, including ours, have instituted acute stroke protocols, with a pediatric acute stroke team that is…”
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Increased prevalence of brain tumors classified as T2 hyperintensities in neurofibromatosis 1 by Griffith, Jennifer L, Morris, Stephanie M, Mahdi, Jasia, Goyal, Manu S, Hershey, Tamara, Gutmann, David H

“…We sought to define the radiologic features that differentiate neoplastic from non-neoplastic T2 hyperintensities (T2Hs) in neurofibromatosis type 1 (NF1) and…”
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OMIC-11. SINGLE CELL RNA SEQUENCING FROM THE CSF OF SUBJECTS WITH H3K27M+ DIPG/DMG TREATED WITH GD2 CAR T-CELLULAR THERAPY by Mochizuki, Aaron, Ramakrishna, Sneha, Good, Zina, Patel, Shabnum, Chinnasamy, Harshini, Yeom, Kristen, Schultz, Liora, Richards, Rebecca, Campen, Cynthia, Reschke, Agnes, Mahdi, Jasia, Toland, Angus, Baggot, Christina, Mavroukakis, Sharon, Egeler, Emily, Moon, Jennifer, Landrum, Kayla, Erickson, Courtney, Rasmussen, Lindsey, Barsan, Valentin, Tamaresis, John, Marcy, Anne, Kunicki, Michael, Celones, Michelle, Ehlinger, Zach, Kurra, Sreevidya, Cornell, Timothy, Partap, Sonia, Fisher, Paul, Grant, Gerald, Vogel, Hannes, Davis, Kara, Feldman, Steven, Sahaf, Bita, Majzner, Robbie, Mackall, Crystal, Monje, Michelle

“…Abstract Introduction We are conducting a Phase I clinical trial utilizing chimeric antigen receptor (CAR) T-cells targeting GD2 (NCT04196413) for…”
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EPCT-14. GD2 CAR T-CELLS MEDIATE CLINICAL ACTIVITY AND MANAGEABLE TOXICITY IN CHILDREN AND YOUNG ADULTS WITH H3K27M-MUTATED DIPG AND SPINAL CORD DMG by Majzner, Robbie, Ramakrishna, Sneha, Mochizuki, Aaron, Patel, Shabnum, Chinnasamy, Harshini, Yeom, Kristen, Schultz, Liora, Richards, Rebecca, Campen, Cynthia, Reschke, Agnes, Mahdi, Jasia, Toland, Angus Martin Shaw, Baggott, Christina, Mavroukakis, Sharon, Egeler, Emily, Moon, Jennifer, Landrum, Kayla, Erickson, Courtney, Rasmussen, Lindsay, Barsan, Valentin, Tamaresis, John, Marcy, Anne, Kunicki, Michael, Fujimoto, Michelle, Ehlinger, Zach, Kurra, Sreevidya, Cornell, Timothy, Partap, Sonia, Fisher, Paul, Grant, Gerald, Vogel, Hannes, Sahaf, Bita, Davis, Kara, Feldman, Steven, Mackall, Crystal, Monje, Michelle

“…Abstract Background We previously discovered high expression of the disialoganglioside GD2 on H3K27M+ gliomas and demonstrated preclinical efficacy of…”
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