Search Results - "Mahdavian, Elahe"

Binding Studies of AICAR and Human Serum Albumin by Spectroscopic, Theoretical, and Computational Methodologies by Hashempour, Shokoufeh, Shahabadi, Nahid, Adewoye, Aishat, Murphy, Brennen, Rouse, Camaray, Salvatore, Brian A, Stratton, Christopher, Mahdavian, Elahe

“…The interactions of small molecule drugs with plasma serum albumin are important because of the influence of such interactions on the pharmacokinetics of these…”
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New Folate-Modified Human Serum Albumin Conjugated to Cationic Lipid Carriers for Dual Targeting of Mitoxantrone against Breast Cancer by Ridha, Abbas A, Kashanian, Soheila, Azandaryani, Abbas H, Rafipour, Ronak, Mahdavian, Elahe

“…In the present work, folic acid-modified human serum albumin conjugated to cationic solid lipid nanoparticles were synthesized as nanocarriers of mitoxantrone…”
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TNBC Therapeutics Based on Combination of Fusarochromanone with EGFR Inhibitors by Carroll, Natalie, Youngblood, Reneau, Smith, Alena, Dragoi, Ana-Maria, Salvatore, Brian A, Mahdavian, Elahe

“…Fusarochromanone is an experimental drug with unique and potent anti-cancer activity. Current cancer therapies often incorporate a combination of drugs to…”
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Fusarochromanone induces G1 cell cycle arrest and apoptosis in COS7 and HEK293 cells by Gu, Ying, Chen, Xin, Shang, Chaowei, Singh, Karnika, Barzegar, Mansoureh, Mahdavian, Elahe, Salvatore, Brian A, Jiang, Shanxiang, Huang, Shile

“…Fusarochromanone (FC101), a mycotoxin produced by the fungus Fusarium equiseti, is frequently observed in the contaminated grains and feedstuffs, which is…”
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Use of in-silico assays to characterize the ADMET profile and identify potential therapeutic targets of fusarochromanone, a novel anti-cancer agent by El-Saadi, Madison Wynne, Williams-Hart, Tara, Salvatore, Brian A, Mahdavian, Elahe

“…Purpose For 30 years nature has provided a plethora of natural products with potential meaningful anti-cancer activity. Fusarochromanone (FC101a) is a small…”
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Exosomes and exosome-loaded scaffolds: Characterization and application in modern regenerative medicine by Khazaei, Fatemeh, Rezakhani, Leila, Alizadeh, Morteza, Mahdavian, Elahe, Khazaei, Mozafar

“…Exosomes (EXOs) are extracellular vesicles derived from the endosome. These heterogeneous nanoparticles (30–150 nm) are secreted from various cells and play…”
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Abstract LBA033: YM155 induces DNA damage and cell death in anaplastic thyroid cancer cells by inhibiting DNA topoisomerase IIα at the ATP binding site by Mackay, Ryan, Weinberger, Paul, Mahdavian, Elahe, Xu, Qinqin

“…Abstract Introduction: Anaplastic thyroid cancer (ATC) is among the most aggressive of all human cancers with a median survival of 4.3 months. Currently, there…”
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An interdisciplinary course on computer‐aided drug discovery to broaden student participation in original scientific research by Stratton, Christopher, Christensen, Avery, Jordan, Chelsey, Salvatore, Brian A., Mahdavian, Elahe

“…We present a new highly interdisciplinary project‐based course in computer aided drug discovery (CADD). This course was developed in response to a call for…”
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A promising dual-drug targeted delivery system in cancer therapy: nanocomplexes of folate-apoferritin-conjugated cationic solid lipid nanoparticles by Amer Ridha, Abbas, Kashanian, Soheila, Rafipour, Ronak, Hemati Azandaryani, Abbas, Zhaleh, Hossein, Mahdavian, Elahe

“…Various nano-sized protein and lipid complexes are being investigated as drug delivery systems. The encapsulation of more than one drug in a single nanocomplex…”
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YM155 Induces DNA Damage and Cell Death in Anaplastic Thyroid Cancer Cells by Inhibiting DNA Topoisomerase IIα at the ATP-Binding Site by Mackay, Ryan P, Weinberger, Paul M, Copland, John A, Mahdavian, Elahe, Xu, Qinqin

“…Anaplastic thyroid cancer (ATC) is among the most aggressive of human cancers, and currently there are few effective treatments for most patients. YM155, first…”
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A review of approaches to direct reverse osmosis membrane recycling: a technical, economic and environmental assessment by Seyedeh Elahe Mahdavian, Seyedeh Masumeh Ghaseminezhad

“…Background and Objective: Global market growth of reverse osmosis (RO) has led to an increase in annual disposal of membrane wastes. Therefore, evaluation of…”
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Development and characterization of folic acid-functionalized apoferritin as a delivery vehicle for epirubicin against MCF-7 breast cancer cells by Gomhor J Alqaraghuli, Hasanain, Kashanian, Soheila, Rafipour, Ronak, Mahdavian, Elahe, Mansouri, Kamran

“…Epirubicin (Epr) is an effective chemotherapeutic drug; however, the clinical amenability of Epr is limited by its highly toxic interaction with normal cells…”
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Mitochondrial Targeting of Vitamin E Succinate Enhances Its Pro-apoptotic and Anti-cancer Activity via Mitochondrial Complex II by Dong, Lan-Feng, Jameson, Victoria J.A., Tilly, David, Cerny, Jiri, Mahdavian, Elahe, Marín-Hernández, Alvaro, Hernández-Esquivel, Luz, Rodríguez-Enríquez, Sara, Stursa, Jan, Witting, Paul K., Stantic, Bela, Rohlena, Jakub, Truksa, Jaroslav, Kluckova, Katarina, Dyason, Jeffrey C., Ledvina, Miroslav, Salvatore, Brian A., Moreno-Sánchez, Rafael, Coster, Mark J., Ralph, Stephen J., Smith, Robin A.J., Neuzil, Jiri

“…Mitochondrial complex II (CII) has been recently identified as a novel target for anti-cancer drugs. Mitochondrially targeted vitamin E succinate (MitoVES) is…”
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Abstract 4566: Fusarochromanone inhibits cell proliferation and induces cell death in COS7 cells by Gu, Ying, Jiang, Shanxiang, Mahdavian, Elahe, Huang, Shile

“…Abstract Fusarochromanone (FC101) is a mycotoxin produced by Fusarium equiseti. Contamination of FC101 occurs frequently in grains and feedstuffs, which has…”
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Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy by Dong, Lan-Feng, Jameson, Victoria J.A., Tilly, David, Prochazka, Lubomir, Rohlena, Jakub, Valis, Karel, Truksa, Jaroslav, Zobalova, Renata, Mahdavian, Elahe, Kluckova, Katarina, Stantic, Marina, Stursa, Jan, Freeman, Ruth, Witting, Paul K., Norberg, Erik, Goodwin, Jacob, Salvatore, Brian A., Novotna, Jana, Turanek, Jaroslav, Ledvina, Miroslav, Hozak, Pavel, Zhivotovsky, Boris, Coster, Mark J., Ralph, Stephen J., Smith, Robin A.J., Neuzil, Jiri

“…Mitochondria are emerging as intriguing targets for anti-cancer agents. We tested here a novel approach, whereby the mitochondrially targeted delivery of…”
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Fusarochromanone Induces G.sub.1 Cell Cycle Arrest and Apoptosis in COS7 and HEK293 Cells by Gu, Ying, Chen, Xin, Shang, Chaowei, Singh, Karnika, Barzegar, Mansoureh, Mahdavian, Elahe, Salvatore, Brian A, Jiang, Shanxiang, Huang, Shile

“…Fusarochromanone (FC101), a mycotoxin produced by the fungus Fusarium equiseti, is frequently observed in the contaminated grains and feedstuffs, which is…”
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Fusarochromanone-induced reactive oxygen species results in activation of JNK cascade and cell death by inhibiting protein phosphatases 2A and 5 by Gu, Ying, Barzegar, Mansoureh, Chen, Xin, Wu, Yang, Shang, Chaowei, Mahdavian, Elahe, Salvatore, Brian A, Jiang, Shanxiang, Huang, Shile

“…Recent studies have shown that fusarochromanone (FC101), a mycotoxin, is cytotoxic in a variety of cell lines. However, the molecular mechanism underlying its…”
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Abstract 1363: Development of novel anticancer agents based on fusarochromanone by Mahdavian, Elahe, Boston, Dakota, Grimes, Reid, Williams-Hart, Tara, Furmanski, Brian, Clifford, John, Salvatore, Brian

“…Abstract The primary goal of this research is to develop novel anti-cancer agents based on fusarochromanone (FC101a), a natural mycotoxin with potent…”
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Liposomal formulation of α-tocopheryl maleamide: In vitro and in vivo toxicological profile and anticancer effect against spontaneous breast carcinomas in mice by Turánek, Jaroslav, Wang, Xiu-Fang, Knötigová, Pavlína, Koudelka, Štěpán, Dong, Lan-Feng, Vrublová, Eva, Mahdavian, Elahe, Procházka, Lubomír, Sangsura, Smink, Vacek, Antonín, Salvatore, Brian A., Neuzil, Jiri

“…The vitamin E analogue α-tocopheryl succinate (α-TOS) is an efficient anti-cancer drug. Improved efficacy was achieved through the synthesis of α-tocopheryl…”
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A novel synthesis of tocopheryl amines and amides by Mahdavian, Elahe, Sangsura, Smink, Landry, Geoffrey, Eytina, John, Salvatore, Brian A.

“…We report the synthesis of tocopheryl amines and amides from commercially available tocopherols. This synthesis improves the yield and diastereomeric purity of…”
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