Search Results - "Mahar, Marcus"
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1
Intrinsic mechanisms of neuronal axon regeneration
Published in Nature reviews. Neuroscience (01-06-2018)“…Permanent disabilities following CNS injuries result from the failure of injured axons to regenerate and rebuild functional connections with their original…”
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2
HDAC5 promotes optic nerve regeneration by activating the mTOR pathway
Published in Experimental neurology (01-07-2019)“…Neurons in the central nervous system (CNS) regenerate poorly compared to their counterparts in the peripheral nervous system. We previously showed that, in…”
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Journal Article -
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Epigenetic regulator UHRF1 inactivates REST and growth suppressor gene expression via DNA methylation to promote axon regeneration
Published in Proceedings of the National Academy of Sciences - PNAS (26-12-2018)“…Injured peripheral sensory neurons switch to a regenerative state after axon injury, which requires transcriptional and epigenetic changes. However, the roles…”
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Journal Article -
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A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle
Published in Developmental cell (26-10-2020)“…Differentiated cells can re-enter the cell cycle to repair tissue damage via a series of discrete morphological and molecular stages coordinated by the…”
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Journal Article -
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Transcriptional and Epigenetic Regulation of Axon Regeneration
Published 01-01-2019“…The mammalian nervous system is a highly intricate network consisting of over a hundred billion specialized cells called neurons. One unique characteristic of…”
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Dissertation