Search Results - "Mahant, Aakash Mahant"

Failure of Herpes Simplex Virus Glycoprotein D Antibodies to Elicit Antibody-Dependent Cell-Mediated Cytotoxicity: Implications for Future Vaccines by Mahant, Aakash Mahant, Guerguis, Sandra, Blevins, Tamara P, Cheshenko, Natalia, Gao, Wei, Anastos, Kathryn, Belshe, Robert B, Herold, Betsy C

“…The glycoprotein D (gD)/AS04 vaccine failed to prevent herpes simplex virus (HSV) 2 in clinical trials. Failure was recapitulated in mice, in which the vaccine…”
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Prolonged Preterm Rupture of Membranes Associated with Neonatal Disseminated Herpes Simplex Virus Type 1 at Birth: Is There a Role for Preemptive Test and Treat Strategies in High-Risk Populations? by Estrada, Fatima, Mahant, Aakash Mahant, Guerguis, Sandra, Sy, Sharlene, Lu, Chuanyong, Reznik, Sandra E, Herold, Betsy C

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90 Placental transfer of SARS-CoV-2 specific antibodies from mothers to newborns by Estrada Trejo, Fatima A., Pfalzgraf, Hadley, Arora, Avish, Mahant, Aakash Mahant, Herold, Betsy

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A non-neutralizing glycoprotein B monoclonal antibody protects against herpes simplex virus disease in mice by Kuraoka, Masayuki, Aschner, Clare Burn, Windsor, Ian W, Mahant, Aakash Mahant, Garforth, Scott J, Kong, Susan Luozheng, Achkar, Jacqueline M, Almo, Steven C, Kelsoe, Garnett, Herold, Betsy C

“…There is an unmet need for monoclonal antibodies (mAbs) for prevention or as adjunctive treatment of herpes simplex virus (HSV) disease. Most vaccine and mAb…”
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Novel Mouse Model of Recurrent Sublethal Herpes Simplex Virus Infection Recapitulates Human Antibody Responses to Primary and Chronic Infection by Mahant, Aakash Mahant, Gualdron, Tania Jaimes, Herold, Betsy C

“…Herpes simplex virus (HSV) vaccine development has been impeded by the absence of predictive preclinical models and defined correlates of immune protection…”
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Antibodies Elicited in Response to a Single Cycle Glycoprotein D Deletion Viral Vaccine Candidate Bind C1q and Activate Complement Mediated Neutralization and Cytolysis by Visciano, Maria Luisa, Mahant, Aakash Mahant, Pierce, Carl, Hunte, Richard, Herold, Betsy C

“…Herpes simplex virus (HSV) prevention is a global health priority but, despite decades of research, there is no effective vaccine. Prior efforts focused on…”
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Humoral Immune Responses to HSV Infections and Placental Transfer of Protective Antibodies; Implications for HSV Vaccine and Monoclonal Antibody Development by Mahant Mahant, Aakash

“…Herpes simplex virus type 1 and type 2 (HSV-1 and HSV-2, respectively) are two of the most prevalent human viruses worldwide. They cause significant global…”
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2125. Determinants of Placental Transfer of HSV-specific Antibodies and the Impact of SARS-CoV-2 Coinfection by Mahant, Aakash Mahant, Estrada, Fatima, Aguilan, Jennifer, Sidoli, Simone, Herold, Betsy

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Greater Durability and Protection against Herpes Simplex Viral Disease following Immunization of Mice with Single-Cycle ΔgD-2 Compared to an Adjuvanted Glycoprotein D Protein Vaccine by Mahant, Aakash Mahant, Gromisch, Matthew S, Kravets, Leah, Burn Aschner, Clare, Herold, Betsy C

“…Herpes simplex viruses (HSV) cause chronic infections with significant morbidity. Prior vaccines, designed to generate neutralizing antibodies (nAbs) targeting…”
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Preclinical development of BCG.HIVA2auxo.int, harboring an integrative expression vector, for a HIV-TB Pediatric vaccine. Enhancement of stability and specific HIV-1 T-cell immunity by Mahant, Aakash, Saubi, Narcís, Eto, Yoshiki, Guitart, Núria, Gatell, Josep Ma, Hanke, Tomáš, Joseph, Joan

“…One of the critical issues that should be addressed in the development of a BCG-based HIV vaccine is genetic plasmid stability. Therefore, to address this…”
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1192: Placental transfer of HSV-specific antibodies from mothers to newborns by Mahant, Aakash, Estrada Trejo, Fatima A., Correa, Anayeli, Loh, Lip, Galen, Benjamin, Herold, Betsy C.

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Murine Model of Maternal Immunization Demonstrates Protective Role for Antibodies That Mediate Antibody-Dependent Cellular Cytotoxicity in Protecting Neonates From Herpes Simplex Virus Type 1 and Type 2 by Kao, Carol M, Goymer, Jessica, Loh, Lip Nam, Mahant, Aakash, Aschner, Clare Burn, Herold, Betsy C

“…Abstract Background Neonatal herpes simplex virus (HSV) disease results in unacceptable morbidity and mortality. The primary humoral immune response to natural…”
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Preclinical development of BCG.HIVA 2auxo.int , harboring an integrative expression vector, for a HIV-TB Pediatric vaccine. Enhancement of stability and specific HIV-1 T-cell immunity by Mahant, Aakash, Saubi, Narcís, Eto, Yoshiki, Guitart, Núria, Gatell, Josep Ma, Hanke, Tomáš, Joseph, Joan

“…One of the critical issues that should be addressed in the development of a BCG-based HIV vaccine is genetic plasmid stability. Therefore, to address this…”
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