Search Results - "Mahaney, M.C"

Presence of knee osteophytes is heritable and linked to regions of CHR. 19 and 2 that contain TGFB1 and SPP2 by Sybouts, E.H, Quillen, E.E, Macrini, T.E, Mahaney, M.C, Cox, L.A, Nicolella, D.P, Havill, L.M

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Heritability of lumbar trabecular bone mechanical properties in baboons by Havill, L.M, Allen, M.R, Bredbenner, T.L, Burr, D.B, Nicolella, D.P, Turner, C.H, Warren, D.M, Mahaney, M.C

“…Abstract Genetic effects on mechanical properties have been demonstrated in rodents, but not confirmed in primates. Our aim was to quantify the proportion of…”
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GWAS of self-reported osteoarthritis in Mexican Americans from the San Antonio Family Study by Havill, L.M, Coan, H.B, Dyer, T.D, Kent, J.W, Choudary, A, Nicolella, D.P, Carless, M.A, Kumar, S, Almeida, M.A, Duggirala, R, Glahn, D.C, Mahaney, M.C, Blangero, J, Curran, J.E

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Variation in osteoarthritis biomarker serum comp levels in Mexican Americans is associated with SNPs in a region of chromosome 22q encompassing MICAL3, BCL2L13, and BID by Coan, H.B, Curran, J.E, Dyer, T.D, Kent, J.W, Choudary, A, Nicolella, D.P, Carless, M.A, Kumar, S, Almeida, M.A, Duggirala, R, Glahn, D.C, Mahaney, M.C, Blangero, J, Havill, L.M

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Genetical genomics of Th1 and Th2 immune response in a baboon model of atherosclerosis risk factors by Vinson, A, Curran, J.E, Johnson, M.P, Dyer, T.D, Moses, E.K, Blangero, J, Cox, L.A, Rogers, J, Havill, L.M, VandeBerg, J.L, Mahaney, M.C

“…Abstract Objective CD4+ T-cells mediate inflammation in atherosclerosis, but additive genetic effects on associated pathways of Th1 and Th2 immune response…”
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A pleiotropic QTL on 2p influences serum Lp-PLA2 activity and LDL cholesterol concentration in a baboon model for the genetics of atherosclerosis risk factors by Vinson, A, Mahaney, M.C, Cox, L.A, Rogers, J, VandeBerg, J.L, Rainwater, D.L

“…Abstract Lipoprotein-associated phospholipase A2 (Lp-PLA2 ), the major portion of which is bound to low-density lipoprotein, is an independent biomarker of…”
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A Quantitative Trait Locus on Chromosome 16q Influences Variation in Plasma HDL-C Levels in Mexican Americans by Mahaney, M C, Almasy, L, Rainwater, D L, VandeBerg, J L, Cole, S A, Hixson, J E, Blangero, J, MacCluer, J W

“…OBJECTIVE—We conducted a whole-genome, multipoint linkage screen to localize a previously reported major locus accounting for 56% to 67% of the additive…”
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1E-5 Inverse correlation between birthweight and serum low-density lipoprotein cholesterol (LDLC) response to a high fat diet in the juvenile baboon by Cox, L.A, Mahaney, M.C, Rainwater, D.L, Nathanielsz, P.W, VandeBerg, J.L

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Bone ALP and OC reference standards in adult baboons (Papio hamadryas) by sex and age by Havill, L.M., Hale, L.G., Newman, D.E., Witte, S.M., Mahaney, M.C.

“…Background  Serum bone‐specific alkaline phosphatase (bone ALP) and intact osteocalcin (OC) are markers of bone formation of interest because of easy…”
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Hematology and blood biochemistry in infant baboons (Papio hamadryas) by Havill, L.M., Snider, C.L., Leland, M.M., Hubbard, G.B., Theriot, S.R., Mahaney, M.C.

“…: Although published normative reference standards for hematologic and clinical chemistry measures are available for adult baboons, their applicability to…”
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Cosupplementation with vitamin E and coenzyme Q10 reduces circulating markers of inflammation in baboons by Wang, X.L, Rainwater, D.L, Mahaney, M.C, Stocker, R

“…Background: Inflammation and oxidative stress are processes that mark early metabolic abnormalities in vascular diseases. Objectives: We explored the effects…”
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baboon as a nonhuman primate model for the study of the genetics of obesity by Comuzzie, A.G, Cole, S.A, Martin, L, Carey, K.D, Mahaney, M.C, Blangero, J, VandeBerg, J.L

“…Objective: At present, rodents represent the most common animal model for research in obesity and its comorbidities (e.g., type 2 diabetes and coronary heart…”
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A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2 by Comuzzie, A.G. (Southwest Foundation for Biomedical Research, San Antonio, TX.), Hixson, J.E, Almasy, L, Mitchell, B.D, Mahaney, M.C, Dyer, T.D, Stern, M.P, MacCluer, J.W, Blangero, J

“…Obesity is a major predisposing factor for the development of several chronic diseases including non-insulin dependent diabetes mellitus (NIDDM) and coronary…”
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A pleiotropic QTL on 2p influences serum Lp-PLA 2 activity and LDL cholesterol concentration in a baboon model for the genetics of atherosclerosis risk factors by Vinson, A., Mahaney, M.C., Cox, L.A., Rogers, J., VandeBerg, J.L., Rainwater, D.L.

“…Lipoprotein-associated phospholipase A 2 (Lp-PLA 2), the major portion of which is bound to low-density lipoprotein, is an independent biomarker of…”
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Osteopenia and osteoporosis in adult baboons (Papio hamadryas) by Havill, L.M., Levine, S.M., Newman, D.E., Mahaney, M.C.

“…Background  Little is known about the degree to which baboons, an important animal model in skeletal research, spontaneously experience age‐related osteopenia…”
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Bone mineral density reference standards in adult baboons ( Papio hamadryas) by sex and age by Havill, L.M, Mahaney, M.C, Czerwinski, S.A, Carey, K.D, Rice, K, Rogers, J

“…Osteoporosis is a progressive condition involving structural deterioration of bone tissue, leading to skeletal fragility and an increased susceptibility to…”
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Genotype-by-sex and environment-by-sex interactions influence variation in serum levels of bone-specific alkaline phosphatase in adult baboons ( Papio hamadryas) by Havill, L.M, Mahaney, M.C, Rogers, J

“…While more than 77% of the people in the US with osteoporosis are women, the contributions of genotype-by-sex (G×S) and environment-by-sex interactions to sex…”
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Quantitative genetic analysis of glucose transporter 4 mRNA levels in baboon adipose by Tejero, M.E, Proffitt, J.M, Cole, S.A, Freeland-Graves, J.H, Cai, G, Peebles, K.W, Cox, L.A, Mahaney, M.C, Rogers, J, VandeBerg, J.L

“…Objective: Glucose transporter 4 (GLUT4) is an insulin‐responsive glucose transporter expressed in adipose tissue. A decrease of the mRNA abundance of GLUT4 in…”
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A Quantitative Trait Locus on Chromosome 5p Influences D-Dimer Levels in the San Antonio Family Heart Study by Diego, V. P., Almasy, L., Rainwater, D. L., Mahaney, M. C., Comuzzie, A. G., Cole, S. A., Tracy, Russell P., Stern, M. P., MacCluer, J. W., Blangero, J.

“…Background. D-dimer is associated with increasing severity of atherosclerosis and with increased risk of a cardiovascular disease (CVD). Methods and Results…”
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Quantitative Trait Locus on Chromosome 12q14.1 Influences Variation in Plasma Plasminogen Levels in the San Antonio Family Heart Study by Santamaría, A., Diego, V. P., Almasy, L., Rainwater, D. L., Mahaney, M. C., Comuzzie, A. G., Cole, S. A., Dyer, T. D., Tracy, R. P., Stern, M. P., Maccluer, J. W., Blangero, J.

“…Plasminogen is a hemostasis-related phenotype and is commonly implicated in thrombotic and bleeding disorders. In the San Antonio Family Heart Study (SAFHS),…”
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