Search Results - "Mahan, Michael J."

Recurrent infection progressively disables host protection against intestinal inflammation by Yang, Won Ho, Heithoff, Douglas M., Aziz, Peter V., Sperandio, Markus, Nizet, Victor, Mahan, Michael J., Marth, Jamey D.

“…Intestinal inflammation is the central pathological feature of colitis and the inflammatory bowel diseases. These syndromes arise from unidentified…”
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An intrinsic mechanism of secreted protein aging and turnover by Yang, Won Ho, Aziz, Peter V., Heithoff, Douglas M., Mahan, Michael J., Smith, Jeffrey W., Marth, Jamey D.

“…The composition and functions of the secreted proteome are controlled by the life spans of different proteins. However, unlike intracellular protein fate,…”
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Neu3 neuraminidase induction triggers intestinal inflammation and colitis in a model of recurrent human food-poisoning by Yang, Won Ho, Westman, Julia S., Heithoff, Douglas M., Sperandio, Markus, Cho, Jin Won, Mahan, Michael J., Marth, Jamey D.

“…Intestinal inflammation is the underlying basis of colitis and the inflammatory bowel diseases. These syndromes originate from genetic and environmental…”
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Correcting a Fundamental Flaw in the Paradigm for Antimicrobial Susceptibility Testing by Ersoy, Selvi C., Heithoff, Douglas M., Barnes, Lucien, Tripp, Geneva K., House, John K., Marth, Jamey D., Smith, Jeffrey W., Mahan, Michael J.

“…The emergence and prevalence of antibiotic-resistant bacteria are an increasing cause of death worldwide, resulting in a global ‘call to action’ to avoid…”
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Intraspecies variation in the emergence of hyperinfectious bacterial strains in nature by Heithoff, Douglas M, Shimp, William R, House, John K, Xie, Yi, Weimer, Bart C, Sinsheimer, Robert L, Mahan, Michael J

“…Salmonella is a principal health concern because of its endemic prevalence in food and water supplies, the rise in incidence of multi-drug resistant strains,…”
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Antimicrobial susceptibility testing to evaluate minimum inhibitory concentration values of clinically relevant antibiotics by Barnes V, Lucien, Heithoff, Douglas M., Mahan, Scott P., House, John K., Mahan, Michael J.

“…Antimicrobial susceptibility testing is used to determine the minimum inhibitory concentration (MIC), the standard measurement of antibiotic activity. Here, we…”
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Microfluidic Chip-Based Detection and Intraspecies Strain Discrimination of Salmonella Serovars Derived from Whole Blood of Septic Mice by PATTERSON, Adriana S, HEITHOFF, Douglas M, FERGUSON, Brian S, SOH, H. Tom, MAHAN, Michael J, PLAXCO, Kevin W

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Coagulation factor protein abundance in the pre-septic state predicts coagulopathic activities that arise during late-stage murine sepsis by Heithoff, Douglas M., Pimienta, Genaro, Mahan, Scott P., Yang, Won Ho, Le, Dzung T., House, John K., Marth, Jamey D., Smith, Jeffrey W., Mahan, Michael J.

“…Although sepsis accounts for 1 in 5 deaths globally, few molecular therapies exist for this condition. The development of effective biomarkers and treatments…”
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Innate mechanism of mucosal barrier erosion in the pathogenesis of acquired colitis by Yang, Won Ho, Aziz, Peter V., Heithoff, Douglas M., Kim, Yeolhoe, Ko, Jeong Yeon, Cho, Jin Won, Mahan, Michael J., Sperandio, Markus, Marth, Jamey D.

“…The colonic mucosal barrier protects against infection, inflammation, and tissue ulceration. Composed primarily of Mucin-2, proteolytic erosion of this barrier…”
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Host-dependent Induction of Transient Antibiotic Resistance: A Prelude to Treatment Failure by Kubicek-Sutherland, Jessica Z., Heithoff, Douglas M., Ersoy, Selvi C., Shimp, William R., House, John K., Marth, Jamey D., Smith, Jeffrey W., Mahan, Michael J.

“…Current antibiotic testing does not include the potential influence of host cell environment on microbial susceptibility and antibiotic resistance, hindering…”
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Conditions That Diminish Myeloid-Derived Suppressor Cell Activities Stimulate Cross-Protective Immunity by Heithoff, Douglas M, Enioutina, Elena Y, Bareyan, Diana, Daynes, Raymond A, Mahan, Michael J

“…Immunity conferred by conventional vaccines is restricted to a narrow range of closely related strains, highlighting the unmet medical need for the development…”
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An Essential Role for DNA Adenine Methylation in Bacterial Virulence by Heithoff, Douglas M., Sinsheimer, Robert L., Low, David A., Mahan, Michael J.

“…Salmonella typhimurium lacking DNA adenine methylase (Dam) were fully proficient in colonization of mucosal sites but showed severe defects in colonization of…”
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Human Salmonella Clinical Isolates Distinct from Those of Animal Origin by Heithoff, Douglas M, Shimp, William R, Lau, Patrick W, Badie, Golnaz, Enioutina, Elena Y, Daynes, Raymond A, Byrne, Barbara A, House, John K, Mahan, Michael J

“…The global trend toward intensive livestock production has led to significant public health risks and industry-associated losses due to an increased incidence…”
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Altered Levels of Salmonella DNA Adenine Methylase Are Associated with Defects in Gene Expression, Motility, Flagellar Synthesis, and Bile Resistance in the Pathogenic Strain 14028 but Not in the Laboratory Strain LT2 by BADIE, Golnaz, HEITHOFF, Douglas M, SINSHEIMER, Robert L, MAHAN, Michael J

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Salmonella DNA Adenine Methylase Mutants Confer Cross-Protective Immunity by HEITHOFF, Douglas M, ENIOUTINA, Elena Y, DAYNES, Raymond A, SINSHEIMER, Robert L, LOW, David A, MAHAN, Michael J

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Comparison of Tissue-Selective Proinflammatory Gene Induction in Mice Infected with Wild-Type, DNA Adenine Methylase-Deficient, and Flagellin-Deficient Salmonella enterica by Simon, Raphael, Heithoff, Douglas M, Mahan, Michael J, Samuel, Charles E

“…Mutants of Salmonella enterica serovar Typhimurium deficient in DNA adenine methylase (Dam) are attenuated for virulence in mice and confer heightened immunity…”
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Accelerated Aging and Clearance of Host Anti-inflammatory Enzymes by Discrete Pathogens Fuels Sepsis by Yang, Won Ho, Heithoff, Douglas M., Aziz, Peter V., Haslund-Gourley, Benjamin, Westman, Julia S., Narisawa, Sonoko, Pinkerton, Anthony B., Millán, José Luis, Nizet, Victor, Mahan, Michael J., Marth, Jamey D.

“…Sepsis is a life-threatening inflammatory syndrome accompanying a bloodstream infection. Frequently secondary to pathogenic bacterial infections, sepsis…”
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Bacterial Infection as Assessed by in vivo Gene Expression by Heithoff, Douglas M., Conner, Christopher P., Hanna, Philip C., Julio, Steven M., Hentschel, Ute, Mahan, Michael J.

“…In vivo expression technology (IVET) has been used to identify > 100 Salmonella typhimurium genes that are specifically expressed during infection of BALB/c…”
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Differential Patterns of Acquired Virulence Genes Distinguish Salmonella strains by Conner, Christopher P., Heithoff, Douglas M., Julio, Steven M., Sinsheimer, Robert L., Mahan, Michael J.

“…Analysis of several Salmonella typhimurium in vivo-induced genes located in regions of atypical base composition has uncovered acquired genetic elements that…”
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Plasma Proteome Signature of Sepsis: a Functionally Connected Protein Network by Pimienta, Genaro, Heithoff, Douglas M., Rosa‐Campos, Alexandre, Tran, Minerva, Esko, Jeffrey D., Mahan, Michael J., Marth, Jamey D., Smith, Jeffrey W.

“…Sepsis is an extreme host response to infection that leads to loss of organ function and cardiovascular integrity. Mortality from sepsis is on the rise…”
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