Search Results - "Mahan, Andrew D"

Conformational Plasticity of the Immunoglobulin Fc Domain in Solution by Remesh, Soumya G., Armstrong, Anthony A., Mahan, Andrew D., Luo, Jinquan, Hammel, Michal

“…Fragment crystallizable (Fc) region of immunoglobulin G (IgG) antibody binds to specific Fc receptors (FcγRs) to control antibody effector functions…”
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A novel method for determination of drug distribution in rat brain tissue sections by LC/MS/MS: functional tissue microanalysis by Masucci, John A, Mahan, Andrew D, Kwasnoski, Joseph D, Caldwell, Gary W

“…Determination of drug distribution in brain and other tissues is important in pharmaceutical research. Tissue drug levels need to be determined routinely as…”
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Elucidating the Mechanism of Multispecific Antibody Aggregation through Subunit Analysis by Poltash, Michael L., Srzentić, Kristina, Beil, Eric, Gorre, Elsa, Damoc, Eugen, Mahan, Andrew D., Nanda, Hirsh, Chowdhury, Partha

“…Multispecific antibody constructs are quickly becoming more common constructs in biopharmaceuticals to improve specificity and efficacy. While the advent of…”
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Functional Relevance of Interleukin-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling by Ge, Jiwan, Remesh, Soumya G., Hammel, Michal, Pan, Si, Mahan, Andrew D., Wang, Shuying, Wang, Xinquan

“…The interleukin 1 (IL-1) receptor family, whose members contain three immunoglobulin-like domains (D1–D3) in the extracellular region, is responsible for…”
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“Lab of the Future”Today: Fully Automated System for High-Throughput Mass Spectrometry Analysis of Biotherapeutics by Waldenmaier, Hans E., Gorre, Elsa, Poltash, Michael L., Gunawardena, Harsha P., Zhai, Xianglin Alex, Li, Jing, Zhai, Bo, Beil, Eric J., Terzo, Joseph C., Lawler, Rose, English, A. Michelle, Bern, Marshall, Mahan, Andrew D., Carlson, Eric, Nanda, Hirsh

“…Here we describe a state-of-the-art, integrated, multi-instrument automated system designed to execute methods involved in mass spectrometry characterization…”
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Structural Basis for Elastolytic Substrate Specificity in Rodent α-Chymases by Kervinen, Jukka, Abad, Marta, Crysler, Carl, Kolpak, Michael, Mahan, Andrew D., Masucci, John A., Bayoumy, Shariff, Cummings, Maxwell D., Yao, Xiang, Olson, Matthew, de Garavilla, Lawrence, Kuo, Lawrence, Deckman, Ingrid, Spurlino, John

“…Divergence of substrate specificity within the context of a common structural framework represents an important mechanism by which new enzyme activity…”
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Functional Relevance of IL-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling by Ge, Jiwan, Remesh, Soumya G., Hammel, Michal, Pan, Si, Mahan, Andrew D., Wang, Shuying, Wang, Xinquan

“…The interleukin 1 (IL-1) receptor family, whose members contain three Ig-like domains (D1-D3) in the extracellular region, is responsible for transmitting…”
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Conformational Plasticity of the Immunoglobulin Fc Domain in Solution by Remesh, Soumya G., Armstrong, Anthony A., Mahan, Andrew D., Luo, Jinquan, Hammel, Michal

“…Fragment crystallizable (Fc) region of immunoglobulin G (IgG) antibody binds to specific Fc receptors (FcγRs) to control antibody effector functions…”
Get full text

Structural Basis for Elastolytic Substrate Specificity in Rodent α-Chymases by Jukka Kervinen, Marta Abad, Carl Crysler, Michael Kolpak, Andrew D. Mahan, John A. Masucci, Shariff Bayoumy, Maxwell D. Cummings, Xiang Yao, Matthew Olson, Lawrence de Garavilla, Lawrence Kuo, Ingrid Deckman, John Spurlino

“…Divergence of substrate specificity within the context of a common structural framework represents an important mechanism by which new enzyme activity…”
Get full text