Search Results - "Mahali, Sidhartha"

ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids by Bowles, Kathryn R., Silva, M. Catarina, Whitney, Kristen, Bertucci, Taylor, Berlind, Joshua E., Lai, Jesse D., Garza, Jacob C., Boles, Nathan C., Mahali, Sidhartha, Strang, Kevin H., Marsh, Jacob A., Chen, Cynthia, Pugh, Derian A., Liu, Yiyuan, Gordon, Ronald E., Goderie, Susan K., Chowdhury, Rebecca, Lotz, Steven, Lane, Keith, Crary, John F., Haggarty, Stephen J., Karch, Celeste M., Ichida, Justin K., Goate, Alison M., Temple, Sally

“…Frontotemporal dementia (FTD) because of MAPT mutation causes pathological accumulation of tau and glutamatergic cortical neuronal death by unknown mechanisms…”
Get full text

Advanced Glycation End Products Induce Lipogenesis: Regulation by Natural Xanthone through Inhibition of ERK and NF-κB by Mahali, Sidhartha K., Verma, Neeharika, Manna, Sunil K.

“…ABSTRACT Advanced glycation end products (AGE) accumulate in diabetic patients and aged persons due to high amounts of 3‐ or 4‐carbon derivatives of glucose…”
Get full text

Defective proteostasis in induced pluripotent stem cell models of frontotemporal lobar degeneration by Mahali, Sidhartha, Martinez, Rita, King, Melvin, Verbeck, Anthony, Harari, Oscar, Benitez, Bruno A., Horie, Kanta, Sato, Chihiro, Temple, Sally, Karch, Celeste M.

“…Impaired proteostasis is associated with normal aging and is accelerated in neurodegeneration. This impairment may lead to the accumulation of protein, which…”
Get full text

Beta-d-glucoside protects against advanced glycation end products (AGEs)-mediated diabetic responses by suppressing ERK and inducing PPAR gamma DNA binding by Mahali, Sidhartha K., Manna, Sunil K.

“…Accumulation of advanced glycation end products (AGEs), due to excessive amounts of 3- or 4-carbon sugars derived from glucose; cause multiple consequences in…”
Get full text

A natural xanthone increases catalase activity but decreases NF-kappa B and lipid peroxidation in U-937 and HepG2 cell lines by Sahoo, Binay K., Zaidi, Adeel H., Gupta, Pankaj, Mokhamatam, Raveendra B., Raviprakash, Nune, Mahali, Sidhartha K., Manna, Sunil K.

“…Mangiferin, a C-glycosyl xanthone, has shown anti-inflammatory, antioxidant, and anti-tumorigenic activities. In the present study, we investigated the…”
Get full text

Conserved gene signatures shared among MAPT mutations reveal defects in calcium signaling by Minaya, Miguel A, Mahali, Sidhartha, Iyer, Abhirami K, Eteleeb, Abdallah M, Martinez, Rita, Huang, Guangming, Budde, John, Temple, Sally, Nana, Alissa L, Seeley, William W, Spina, Salvatore, Grinberg, Lea T, Harari, Oscar, Karch, Celeste M

“…More than 50 mutations in the gene result in heterogeneous forms of frontotemporal lobar dementia with tau inclusions (FTLD-Tau). However, early pathogenic…”
Get full text

Defective proteostasis in patient‐derived iPSC‐astrocytes and neurons carrying a MAPT IVS10+16 mutation by Mahali, Sidhartha, Karch, Celeste

“…Background Impaired proteostasis is associated with normal aging and is accelerated in neurodegeneration. This impairment may lead to the toxic protein…”
Get full text

Defective proteostasis in patient‐derived iPSC astrocytes and neurons carrying a MAPT IVS10+16 mutation by Mahali, Sidhartha, Martinez, Rita, Hu, Miwei, Marsh, Jacob, Temple, Sally, Karch, Celeste M.

“…Background Impaired proteostasis is associated with normal aging and is accelerated in neurodegeneration. This impairment may lead to the toxic accumulation of…”
Get full text

Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation by Filipello, Fabia, You, Shih-Feng, Mirfakhar, Farzaneh S., Mahali, Sidhartha, Bollman, Bryan, Acquarone, Mariana, Korvatska, Olena, Marsh, Jacob A., Sivaraman, Anirudh, Martinez, Rita, Cantoni, Claudia, De Feo, Luca, Ghezzi, Laura, Minaya, Miguel A., Renganathan, Arun, Cashikar, Anil G., Satoh, Jun-Ichi, Beatty, Wandy, Iyer, Abhirami K., Cella, Marina, Raskind, Wendy H., Piccio, Laura, Karch, Celeste M.

“…TREM2 is an innate immune receptor expressed by microglia in the adult brain. Genetic variation in the TREM2 gene has been implicated in risk for Alzheimer’s…”
Get full text

LYSOSOMAL DYSFUNCTION IN STEM CELL MODELS OF TAUOPATHY by Mahali, Sidhartha, Jiang, Shan, Hsu, Simon, Benitez, Bruno, Harari, Oscar, Cruchaga, Carlos, Karch, Celeste M.

Get full text

O3‐07‐02: LYSOSOMAL DYSFUNCTION IN STEM CELL MODELS OF TAUOPATHY by Mahali, Sidhartha, Jiang, Shan, Hsu, Simon, Benitez, Bruno, Harari, Oscar, Cruchaga, Carlos, Karch, Celeste M.

Get full text

Advanced Glycation End Products Induce Lipogenesis: Regulation by Natural Xanthone through Inhibition of ERK and NF-[kappa]B by Mahali, Sidhartha K, Verma, Neeharika, Manna, Sunil K

“…Advanced glycation end products (AGE) accumulate in diabetic patients and aged persons due to high amounts of 3- or 4-carbon derivatives of glucose…”
Get full text

O2‐12‐01: LYSOSOMAL DYSFUNCTION AND ALTERED TAU METABOLISM IN STEM CELL MODELS OF AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE by Mahali, Sidhartha, Hsu, Simon, Benitez, Bruno, Martinez, Rita, Goate, Alison M., Karch, Celeste

Get full text

LYSOSOMAL DYSFUNCTION AND ALTERED TAU METABOLISM IN STEM CELL MODELS OF AUTOSOMAL DOMINANT ALZHEIMER’S DISEASE by Mahali, Sidhartha, Hsu, Simon, Benitez, Bruno, Martinez, Rita, Goate, Alison M., Karch, Celeste

Get full text

Functional characterization of hiPSCs‐derived glial cells and neurons from patients harboring a TREM2 loss of function mutation by Filipello, Fabia, You, Shih‐Feng, Martinez, Rita, Korvatska, Olena, Raskind, Wendy H, Mahali, Sidhartha, Ghezzi, Laura, Wandy, Beatty, Cella, Marina, Piccio, Laura, Karch, Celeste M.

“…Background Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune receptor expressed by microglia in the adult brain. Homozygous loss of…”
Get full text