Search Results - "Mahajan, Vinit B"

Unexpected mutations after CRISPR–Cas9 editing in vivo by Schaefer, Kellie A, Wu, Wen-Hsuan, Colgan, Diana F, Tsang, Stephen H, Bassuk, Alexander G, Mahajan, Vinit B

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Precision Medicine: Genetic Repair of Retinitis Pigmentosa in Patient-Derived Stem Cells by Bassuk, Alexander G., Zheng, Andrew, Li, Yao, Tsang, Stephen H., Mahajan, Vinit B.

“…Induced pluripotent stem cells (iPSCs) generated from patient fibroblasts could potentially be used as a source of autologous cells for transplantation in…”
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Aflibercept Therapy for Exudative Age-related Macular Degeneration Resistant to Bevacizumab and Ranibizumab by Bakall, Benjamin, Folk, James C, Boldt, H. Culver, Sohn, Elliott H, Stone, Edwin M, Russell, Stephen R, Mahajan, Vinit B

“…Purpose To evaluate the outcome of intravitreal injection of aflibercept in cases with exudative age-related macular degeneration, (AMD) resistant to…”
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Intravitreal Anti-VEGF Injections in Pregnancy: Case Series and Review of Literature by Polizzi, Silvio, Mahajan, Vinit B

“…The use of intravitreal antivascular endothelial growth factor (anti-VEGF) injection is gaining wide acceptance as an off-label therapy for diseases that may…”
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Recessive coding and regulatory mutations in FBLIM1 underlie the pathogenesis of chronic recurrent multifocal osteomyelitis (CRMO) by Cox, Allison J, Darbro, Benjamin W, Laxer, Ronald M, Velez, Gabriel, Bing, Xinyu, Finer, Alexis L, Erives, Albert, Mahajan, Vinit B, Bassuk, Alexander G, Ferguson, Polly J

“…Chronic recurrent multifocal osteomyelitis (CRMO) is a rare, pediatric, autoinflammatory disease characterized by bone pain due to sterile osteomyelitis, and…”
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Proteomic insight into the molecular function of the vitreous by Skeie, Jessica M, Roybal, C Nathaniel, Mahajan, Vinit B

“…The human vitreous contains primarily water, but also contains proteins which have yet to be fully characterized. To gain insight into the four vitreous…”
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Quantitative progression of retinitis pigmentosa by optical coherence tomography angiography by Jauregui, Ruben, Park, Karen Sophia, Duong, Jimmy K., Mahajan, Vinit B., Tsang, Stephen H.

“…Optical coherence tomography angiography (OCT-A) is a non-invasive alternative to fluorescein angiography that allows for the study of the retinal and…”
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CRISPR Repair Reveals Causative Mutation in a Preclinical Model of Retinitis Pigmentosa by Wu, Wen-Hsuan, Tsai, Yi-Ting, Justus, Sally, Lee, Ting-Ting, Zhang, Lijuan, Lin, Chyuan-Sheng, Bassuk, Alexander G, Mahajan, Vinit B, Tsang, Stephen H

“…Massive parallel sequencing enables identification of numerous genetic variants in mutant organisms, but determining pathogenicity of any one mutation can be…”
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HTRA1, an age‐related macular degeneration protease, processes extracellular matrix proteins EFEMP1 and TSP1 by Lin, Michael K., Yang, Jin, Hsu, Chun Wei, Gore, Anuradha, Bassuk, Alexander G., Brown, Lewis M., Colligan, Ryan, Sengillo, Jesse D., Mahajan, Vinit B., Tsang, Stephen H.

“…Summary High‐temperature requirement protein A1 (HTRA1) is a serine protease secreted by a number of tissues including retinal pigment epithelium (RPE). A…”
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Investigation of Cas9 antibodies in the human eye by Toral, Marcus A., Charlesworth, Carsten T., Ng, Benjamin, Chemudupati, Teja, Homma, Shota, Nakauchi, Hiromitsu, Bassuk, Alexander G., Porteus, Matthew H., Mahajan, Vinit B.

“…Preexisting immunity against Cas9 proteins in humans represents a safety risk for CRISPR–Cas9 technologies. However, it is unclear to what extent preexisting…”
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Proteomic interactions in the mouse vitreous-retina complex by Skeie, Jessica M, Mahajan, Vinit B

“…Human vitreoretinal diseases are due to presumed abnormal mechanical interactions between the vitreous and retina, and translational models are limited. This…”
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Sex Differences in the Repair of Retinal Detachments in the United States by Callaway, Natalia F., Vail, Daniel, Al-Moujahed, Ahmad, Ludwig, Cassie, Ji, Marco H., Mahajan, Vinit B., Pershing, Suzann, Moshfeghi, Darius M.

“…To investigate differences between women and men in the repair of rhegmatogenous retinal detachments (RRDs) in the United States. Retrospective cohort study…”
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Liquid biopsy proteomics of uveal melanoma reveals biomarkers associated with metastatic risk by Velez, Gabriel, Nguyen, Huy V, Chemudupati, Teja, Ludwig, Cassie A, Toral, Marcus, Reddy, Sunil, Mruthyunjaya, Prithvi, Mahajan, Vinit B

“…Keywords: Proteomics, Vitreous, Liquid biopsy, Uveal melanoma, Cancer, Biomarker, SCFR, HGFR, STAT3…”
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Automated Early Detection of Diabetic Retinopathy by Abràmoff, Michael D., MD, PhD, Reinhardt, Joseph M., PhD, Russell, Stephen R., MD, Folk, James C., MD, Mahajan, Vinit B., MD, PhD, Niemeijer, Meindert, PhD, Quellec, Gwénolé, PhD

“…Purpose To compare the performance of automated diabetic retinopathy (DR) detection, using the algorithm that won the 2009 Retinopathy Online Challenge…”
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Hardwiring tissue-specific AAV transduction in mice through engineered receptor expression by Zengel, James, Wang, Yu Xin, Seo, Jai Woong, Ning, Ke, Hamilton, James N., Wu, Bo, Raie, Marina, Holbrook, Colin, Su, Shiqi, Clements, Derek R., Pillay, Sirika, Puschnik, Andreas S., Winslow, Monte M., Idoyaga, Juliana, Nagamine, Claude M., Sun, Yang, Mahajan, Vinit B., Ferrara, Katherine W., Blau, Helen M., Carette, Jan E.

“…The development of transgenic mouse models that express genes of interest in specific cell types has transformed our understanding of basic biology and…”
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Proteomic analysis of the human retina reveals region-specific susceptibilities to metabolic- and oxidative stress-related diseases by Velez, Gabriel, Machlab, Daniel A, Tang, Peter H, Sun, Yang, Tsang, Stephen H, Bassuk, Alexander G, Mahajan, Vinit B

“…Differences in regional protein expression within the human retina may explain molecular predisposition of specific regions to ophthalmic diseases like…”
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Silicone oil-induced ocular hypertension and glaucomatous neurodegeneration in mouse by Zhang, Jie, Li, Liang, Huang, Haoliang, Fang, Fang, Webber, Hannah C, Zhuang, Pei, Liu, Liang, Dalal, Roopa, Tang, Peter H, Mahajan, Vinit B, Sun, Yang, Li, Shaohua, Zhang, Mingchang, Goldberg, Jeffrey L, Hu, Yang

“…Understanding the molecular mechanism of glaucoma and development of neuroprotectants is significantly hindered by the lack of a reliable animal model that…”
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Neuroprotective effects of naltrexone in a mouse model of post-traumatic seizures by Rodriguez, Saul, Sharma, Shaunik, Tiarks, Grant, Peterson, Zeru, Jackson, Kyle, Thedens, Daniel, Wong, Angela, Keffala-Gerhard, David, Mahajan, Vinit B., Ferguson, Polly J., Newell, Elizabeth A., Glykys, Joseph, Nickl-Jockschat, Thomas, Bassuk, Alexander G.

“…Traumatic Brain Injury (TBI) induces neuroinflammatory response that can initiate epileptogenesis, which develops into epilepsy. Recently, we identified…”
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Gain-of-function mutations in a member of the Src family kinases cause autoinflammatory bone disease in mice and humans by Abe, Koichiro, Cox, Allison, Takamatsu, Nobuhiko, Velez, Gabriel, Laxer, Ronald M., Tse, Shirley M. L., Mahajan, Vinit B., Bassuk, Alexander G., Fuchs, Helmut, Ferguson, Polly J., de Angelis, Martin Hrabe

“…Autoinflammatory syndromes are characterized by dysregulation of the innate immune response with subsequent episodes of acute spontaneous inflammation. Chronic…”
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Retinal and choroidal angiogenesis: a review of new targets by Cabral, Thiago, Mello, Luiz Guilherme M, Lima, Luiz H, Polido, Júlia, Regatieri, Caio V, Belfort, Jr, Rubens, Mahajan, Vinit B

“…Retinal and choroidal neovascularization are a major cause of significant visual impairment, worldwide. Understanding the various factors involved in the…”
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