Search Results - "Mahajan, Sudipta"

Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases by Farmer, Luc J, Ledeboer, Mark W, Hoock, Thomas, Arnost, Michael J, Bethiel, Randy S, Bennani, Youssef L, Black, James J, Brummel, Christopher L, Chakilam, Ananthsrinivas, Dorsch, Warren A, Fan, Bin, Cochran, John E, Halas, Summer, Harrington, Edmund M, Hogan, James K, Howe, David, Huang, Hui, Jacobs, Dylan H, Laitinen, Leena M, Liao, Shengkai, Mahajan, Sudipta, Marone, Valerie, Martinez-Botella, Gabriel, McCarthy, Pamela, Messersmith, David, Namchuk, Mark, Oh, Luke, Penney, Marina S, Pierce, Albert C, Raybuck, Scott A, Rugg, Arthur, Salituro, Francesco G, Saxena, Kumkum, Shannon, Dean, Shlyakter, Dina, Swenson, Lora, Tian, Shi-Kai, Town, Christopher, Wang, Jian, Wang, Tiansheng, Wannamaker, M. Woods, Winquist, Raymond J, Zuccola, Harmon J

“…While several therapeutic options exist, the need for more effective, safe, and convenient treatment for a variety of autoimmune diseases persists. Targeting…”
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STAT signaling in the pathogenesis and treatment of leukemias by Lin, T S, Mahajan, S, Frank, D A

“…Leukemias continue to cause significant mortality in adults and children, and the use of standard cytotoxic chemotherapy has reached a therapeutic plateau…”
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Inhibition of MAP Kinase Kinase Causes Morphological Reversion and Dissociation between Soft Agar Growth and in Vivo Tumorigenesis in Angiosarcoma Cells by LaMontagne Jr, Kenneth R., Moses, Marsha A., Wiederschain, Dmitri, Mahajan, Sudipta, Holden, Jeannine, Ghazizadeh, Hamid, Frank, David A., Arbiser, Jack L.

“…Activated ras causes increased activity of several signal transduction systems, including the mitogen-activated protein kinase kinase (MAPKK) pathway and the…”
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VX-509 (decernotinib) is a potent and selective janus kinase 3 inhibitor that attenuates inflammation in animal models of autoimmune disease by Mahajan, Sudipta, Hogan, James K, Shlyakhter, Dina, Oh, Luke, Salituro, Francesco G, Farmer, Luc, Hoock, Thomas C

“…Cytokines, growth factors, and other chemical messengers rely on a class of intracellular nonreceptor tyrosine kinases known as Janus kinases (JAKs) to rapidly…”
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Structural Basis for Isoform Selectivity in a Class of Benzothiazole Inhibitors of Phosphoinositide 3‑Kinase γ by Collier, Philip N., Martinez-Botella, Gabriel, Cornebise, Mark, Cottrell, Kevin M., Doran, John D., Griffith, James P., Mahajan, Sudipta, Maltais, François, Moody, Cameron S., Huck, Emilie Porter, Wang, Tiansheng, Aronov, Alex M.

“…Phosphoinositide 3-kinase γ (PI3Kγ) is an attractive target to potentially treat a range of disease states. Herein, we describe the evolution of a reported…”
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Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3‑Kinase γ (PI3Kγ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS) by Come, Jon H, Collier, Philip N, Henderson, James A, Pierce, Albert C, Davies, Robert J, Le Tiran, Arnaud, O’Dowd, Hardwin, Bandarage, Upul K, Cao, Jingrong, Deininger, David, Grey, Ron, Krueger, Elaine B, Lowe, Derek B, Liang, Jianglin, Liao, Yusheng, Messersmith, David, Nanthakumar, Suganthi, Sizensky, Emmanuelle, Wang, Jian, Xu, Jinwang, Chin, Elaine Y, Damagnez, Veronique, Doran, John D, Dworakowski, Wojciech, Griffith, James P, Jacobs, Marc D, Khare-Pandit, Suvarna, Mahajan, Sudipta, Moody, Cameron S, Aronov, Alex M

“…The lipid kinase phosphoinositide 3-kinase γ (PI3Kγ) has attracted attention as a potential target to treat a variety of autoimmune disorders, including…”
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Discovery of Highly Isoform Selective Thiazolopiperidine Inhibitors of Phosphoinositide 3‑Kinase γ by Collier, Philip N., Messersmith, David, Le Tiran, Arnaud, Bandarage, Upul K., Boucher, Christina, Come, Jon, Cottrell, Kevin M., Damagnez, Veronique, Doran, John D., Griffith, James P., Khare-Pandit, Suvarna, Krueger, Elaine B., Ledeboer, Mark W., Ledford, Brian, Liao, Yusheng, Mahajan, Sudipta, Moody, Cameron S., Roday, Setu, Wang, Tiansheng, Xu, Jinwang, Aronov, Alex M.

“…A series of high affinity second-generation thiazolopiperidine inhibitors of PI3Kγ were designed based on some general observations around lipid kinase…”
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Discovery of a Novel Series of Potent and Selective Alkynylthiazole-Derived PI3Kγ Inhibitors by Bandarage, Upul K, Aronov, Alex M, Cao, Jingrong, Come, Jon H, Cottrell, Kevin M, Davies, Robert J, Giroux, Simon, Jacobs, Marc, Mahajan, Sudipta, Messersmith, David, Moody, Cameron S, Swett, Rebecca, Xu, Jinwang

“…Phosphoinositide 3-kinases (PI3Ks) are a family of enzymes that control a wide variety of cellular functions such as cell growth, proliferation,…”
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The Generation and Characterization of a Cell Line Derived from a Sporadic Renal Angiomyolipoma by Arbiser, Jack L., Yeung, Raymond, Weiss, Sharon W., Arbiser, Zoya K., Amin, Mahul B., Cohen, Cynthia, Frank, David, Mahajan, Sudipta, Herron, G. Scott, Yang, Jiwei, Onda, Hiroki, Zhang, H.B., Bai, Xianhe, Uhlmann, Erik, Loehr, Allison, Northrup, Hope, Au, Paul, Davis, Ian, Fisher, David E., Gutmann, David H.

“…Angiomyolipomas are benign tumors of the kidney derived from putative perivascular epithelioid cells, that may undergo differentiation into cells with features…”
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CRISPR/Cas9 Genome Editing to Treat Sickle Cell Disease and B-Thalassemia: Re-Creating Genetic Variants to Upregulate Fetal Hemoglobin Appear Well-Tolerated, Effective and Durable by Lin, Michelle I., Paik, Elizabeth, Mishra, Bibhu, Burkhardt, David, Kernytsky, Andrew, Pettiglio, Michael, Chen, Yi-Shan, Tomkinson, Kaleigh, Woo, Amanda, Cortes, Mauricio, Tan, Siyuan, Borland, Todd D, Klein, Lawrence, Yen, Angela, Mahajan, Sudipta, Chan, Eric, Eustace, Brenda, Porteus, Matthew, Chakraborty, Tirtha, Cowan, Chad, Novak, Rodger, Lundberg, Ante

“…Persistent expression of fetal hemoglobin (HbF) beyond the neonatal period is a rare, naturally-occurring condition, referred to as the Hereditary Persistence…”
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Abstract LB-B15: A novel PI3K gamma isoform selective small molecule kinase inhibitor demonstrates single agent anti-tumor activity and enhanced combination activity with checkpoint blockade in syngeneic mouse models of cancer by Saha, Saurabh, Zhang, Linping, Hoock, Thomas, Aronov, Alex, Mahajan, Sudipta, Boyd, Michael, Come, Jon, Damagnez, Veronique, Dworakowski, Wojciech, Khare-Pandit, Suvarna, LeTiran, Arnaud, Moody, Cameron, O'Dowd, Harwin, Prezioso, Joseph, Roday, Setu, Zhang, Xiaoyan M.

“…Abstract Immune checkpoint inhibitors have generated impressive clinical responses, however, a number of patients and cancer types remain resistant to…”
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Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling by Frank, David A, Mahajan, Sudipta, Ritz, Jerome

“…Fludarabine is a nucleoside analog used in the treatment of hematologic malignancies that can induce severe and prolonged immunosuppression. Although it can be…”
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B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues by Frank, D A, Mahajan, S, Ritz, J

“…To explore the pathogenesis of chronic lymphocytic leukemia (CLL), we examined whether phosphorylation of one or more signal transducer and activator of…”
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Janus Kinase 2 Inhibitors. Synthesis and Characterization of a Novel Polycyclic Azaindole by Wang, Tiansheng, Duffy, John P, Wang, Jian, Halas, Summer, Salituro, Francesco G, Pierce, Albert C, Zuccola, Harmon J, Black, James R, Hogan, James K, Jepson, Scott, Shlyakter, Dina, Mahajan, Sudipta, Gu, Yong, Hoock, Thomas, Wood, Mark, Furey, Brinley F, Frantz, J. Daniel, Dauffenbach, Lisa M, Germann, Ursula A, Fan, Bin, Namchuk, Mark, Bennani, Youssef L, Ledeboer, Mark W

“…The synthesis and characterization of a novel polycyclic azaindole based derivative is disclosed, and its binding to JAK2 is described. The compound is further…”
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2-Aminopyrazolo[1,5- a]pyrimidines as potent and selective inhibitors of JAK2 by Ledeboer, Mark W., Pierce, Albert C., Duffy, John P., Gao, Huai, Messersmith, David, Salituro, Francesco G., Nanthakumar, Suganthini, Come, Jon, Zuccola, Harmon J., Swenson, Lora, Shlyakter, Dina, Mahajan, Sudipta, Hoock, Thomas, Fan, Bin, Tsai, Wan-Jung, Kolaczkowski, Elaine, Carrier, Scott, Hogan, James K., Zessis, Richard, Pazhanisamy, S., Bennani, Youssef L.

“…The discovery and structure based optimization of a novel series of 2-amino-pyrazolo[1,5- a]pyrimidines of potent and selective inhibitors of JAK2 is…”
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IL-6-induced survival of colorectal carcinoma cells is inhibited by butyrate through down-regulation of the IL-6 receptor by Yuan, Hanna, Liddle, Forrester J., Mahajan, Sudipta, Frank, David A.

“…Colorectal carcinoma cells are characterized by over-expression of IL-6 and the IL-6 receptor, an autocrine loop that promotes the development of many tumors…”
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TEL/PDGFβR fusion protein activates STAT1 and STAT5: A common mechanism for transformation by tyrosine kinase fusion proteins by Wilbanks, Alyson M., Mahajan, Sudipta, Frank, David A., Druker, Brian J., Gilliland, D.Gary, Carroll, Martin

“…TEL/PDGFβR is a tyrosine kinase fusion protein associated with the pathogenesis of chronic myelomonocytic leukemia. The following experiments were undertaken…”
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Altered interleukin-12 responsiveness in Th1 and Th2 cells is associated with the differential activation of stat5 and STAT1 by GOLLOB, J. A, MURPHY, E. A, MAHAJAN, S, SCHNIPPER, C. P, RITZ, J, FRANK, D. A

“…T-cell activation in response to interleukin-12 (IL-12) is mediated through signaling events that include the tyrosine phosphorylation of STAT4. IL-12…”
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The Generation and Characterization of a Cell Line Derived from a Sporadic Renal Angiomyolipoma : Use of Telomerase to Obtain Stable Populations of Cells from Benign Neoplasms by Arbiser, Jack L, Yeung, Raymond, Weiss, Sharon W, Arbiser, Zoya K, Amin, Mahul B, Cohen, Cynthia, Frank, David, Mahajan, Sudipta, Herron, G. Scott, Yang, Jiwei, Onda, Hiroki, Zhang, H. B, Bai, Xianhe, Uhlmann, Erik, Loehr, Allison, Northrup, Hope, Au, Paul, Davis, Ian, Fisher, David E, Gutmann, David H

“…Angiomyolipomas are benign tumors of the kidney derived from putative perivascular epithelioid cells, that may undergo differentiation into cells with features…”
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CD2 stimulation leads to the delayed and prolonged activation of STAT1 in T cells but not NK cells by Mahajan, Sudipta, Gollob, Jared A, Ritz, Jerome, Frank, David A

“…T lymphocytes can be activated by soluble factors such as cytokines or through direct cell-cell interactions. Although cytokine receptors are known to signal…”
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