Search Results - "Mahadevappa, Ravikiran"
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DNA replication licensing proteins: Saints and sinners in cancer
Published in Seminars in cancer biology (01-10-2019)“…Pictorial abstract: DNA replication is initiated and regulated by DNA replication licensing complex which includes ORC, CDC6, Cdt1 and MCM2–7 complex. A…”
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The prognostic significance of Cdc6 and Cdt1 in breast cancer
Published in Scientific reports (20-04-2017)“…DNA replication is a critical step in cell proliferation. Overexpression of MCM2-7 genes correlated with poor prognosis in breast cancer patients. However, the…”
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Megalin in acute kidney injury: foe and friend
Published in American journal of physiology. Renal physiology (15-01-2014)“…The kidney proximal tubule is a key target in many forms of acute kidney injury (AKI). The multiligand receptor megalin is responsible for the normal proximal…”
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Phytochemicals - A Novel and Prominent Source of Anti-cancer Drugs Against Colorectal Cancer
Published in Combinatorial chemistry & high throughput screening (01-01-2017)“…Colorectal cancer (CRC) is a malignant disease whose incidence and mortality rates are greatly influenced by environmental factors. Under-treatment of CRC such…”
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DNA Replication Licensing Protein MCM10 Promotes Tumor Progression and Is a Novel Prognostic Biomarker and Potential Therapeutic Target in Breast Cancer
Published in Cancers (22-08-2018)“…Breast cancer is one of the most common malignancies in women worldwide. In breast cancer, the cell proliferation rate is known to influence the cancer…”
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Venom-based peptide therapy: insights into anti-cancer mechanism
Published in Oncotarget (21-11-2017)“…The 5-year relative survival rate of all types of cancer has increased significantly over the past three decades partly due to the targeted therapy. However,…”
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Cancer plasticity: Investigating the causes for this agility
Published in Seminars in cancer biology (01-01-2023)“…Cancer is not a hard-wired phenomenon but an evolutionary disease. From the onset of carcinogenesis, cancer cells continuously adapt and evolve to satiate…”
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Triggering of cancer cell cycle arrest by a novel scorpion venom‐derived peptide—Gonearrestide
Published in Journal of cellular and molecular medicine (01-09-2018)“…In this study, a novel scorpion venom‐derived peptide named Gonearrestide was identified in an in‐house constructed scorpion venom library through a…”
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Venom Peptides: Improving Specificity in Cancer Therapy
Published in Trends in cancer (01-09-2017)“…Venom peptides (VPs) exhibit high specificity and selectivity towards cancer cells, with effects on cell proliferation, invasion, migration, and angiogenesis,…”
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Over-Activation of Minichromosome Maintenance Protein 10 Promotes Genomic Instability in Early Stages of Breast Cancer
Published in International journal of biological sciences (2022)“…Genomic instability is considered as one of the key hallmark during cancer development and progression. Cellular mechanisms, such as DNA replication…”
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