Search Results - "Magrath, Justin W."

Transcriptomic analysis identifies B-lymphocyte kinase as a therapeutic target for desmoplastic small round cell tumor cancer stem cell-like cells by Magrath, Justin W., Flinchum, Dane A., Hartono, Alifiani B., Sampath, Shruthi Sanjitha, O’Grady, Tina M., Baddoo, Melody, Haoyang, Liang, Xu, Xiaojiang, Flemington, Erik K., Lee, Sean B.

“…Desmoplastic small round cell tumor (DSRCT) is an aggressive pediatric cancer caused by the EWSR1-WT1 fusion oncoprotein. The tumor is refractory to treatment…”
Get full text

Genomic Breakpoint Characterization and Transcriptome Analysis of Metastatic, Recurrent Desmoplastic Small Round Cell Tumor by Magrath, Justin W., Flinchum, Dane A., Hartono, Alifiani B., Goldberg, Ilon N., Espinosa-Cotton, Madelyn, Moroz, Krzysztof, Cheung, Nai-Kong V., Lee, Sean B.

“…Desmoplastic small round cell tumor (DSRCT) is a rare pediatric cancer caused by the EWSR1-WT1 fusion oncogene. Despite initial response to chemotherapy, DSRCT…”
Get full text

Desmoplastic small round cell tumor: from genomics to targets, potential paths to future therapeutics by Magrath, Justin W, Espinosa-Cotton, Madelyn, Flinchum, Dane A, Sampath, Shruthi Sanjitha, Cheung, Nai Kong, Lee, Sean B

“…Desmoplastic Small Round Cell Tumor (DSRCT) is a highly aggressive pediatric cancer caused by a reciprocal translocation between chromosomes 11 and 22, leading…”
Get full text

Desmoplastic small round cell tumor cancer stem cell-like cells resist chemotherapy but remain dependent on the EWSR1-WT1 oncoprotein by Magrath, Justin W, Kang, Hong-Jun, Hartono, Alifiani, Espinosa-Cotton, Madelyn, Somwar, Romel, Ladanyi, Marc, Cheung, Nai-Kong V, Lee, Sean B

“…Desmoplastic Small Round Cell Tumor (DSRCT) is a rare and aggressive pediatric cancer driven by the fusion oncogene. Combinations of chemotherapy, radiation…”
Get full text

Acidic pH with coordinated reduction of basic fibroblast growth factor maintains the glioblastoma stem cell-like phenotype in vitro by Haley, Elizabeth M., Tilson, Samantha G., Triantafillu, Ursula L., Magrath, Justin W., Kim, Yonghyun

“…Glioblastoma stem cells (GSCs) are a unique subpopulation of cells within glioblastoma multiforme (GBM) brain tumors that possess the ability to self-renew and…”
Get full text

Enzalutamide induces cytotoxicity in desmoplastic small round cell tumor independent of the androgen receptor by Magrath, Justin W., Goldberg, Ilon N., Truong, Danh D., Hartono, Alifiani B., Sampath, Shruthi Sanjitha, Jackson, Chandler E., Ghosh, Anushka, Cardin, Derrick L., Zhang, Haitao, Ludwig, Joseph A., Lee, Sean B.

“…Desmoplastic Small Round Cell Tumor (DSRCT) is a rare, pediatric cancer caused by the EWSR1::WT1 fusion protein. DSRCT predominantly occurs in males, which…”
Get full text

Salinomycin's potential to eliminate glioblastoma stem cells and treat glioblastoma multiforme (Review) by Magrath, Justin W, Kim, Yonghyun

“…Glioblastoma multiforme (GBM) is the most common and deadliest form of primary brain tumor. Despite treatment with surgery, radiotherapy, and chemotherapy with…”
Get full text

Comprehensive Transcriptomic Analysis of EWSR1::WT1 Targets Identifies CDK4/6 Inhibitors as an Effective Therapy for Desmoplastic Small Round Cell Tumors by Magrath, Justin W, Sampath, Shruthi Sanjitha, Flinchum, Dane A, Hartono, Alifiani B, Goldberg, Ilon N, Boehling, Julia R, Savkovic, Suzana D, Lee, Sean B

“…Desmoplastic small round cell tumors (DSRCT) are a type of aggressive, pediatric sarcoma characterized by the EWSR1::WT1 fusion oncogene. Targeted therapies…”
Get full text

In vitro demonstration of salinomycin as a novel chemotherapeutic agent for the treatment of SOX2‑positive glioblastoma cancer stem cells by Magrath, Justin W, Raney, Wilson R, Kim, Yonghyun

“…Glioblastoma multiforme (GBM) is the deadliest and most common form of primary brain tumor. Conventional treatments are ineffective at treating GBM due to the…”
Get full text

Association of Insurance Status with Patient Health at New Orleans Student-Run Free Clinics by Magrath, Justin W., Janfaza, Samantha A., Abdulhafiz, Nadia S., Johnson, Adedoyin E., Siddiqui, Neha, Tran, Torrence, Byrne, Rebekah

“…Since the closure of Charity Hospital after Hurricane Katrina, New Orleans Student-Run Free Clinics have helped fill the resulting void in healthcare access…”
Get full text

Abstract 902: Identification, characterization, and targeting of desmoplastic small round cell tumor cancer stem cell-like cells by Magrath, Justin W., Hartono, Alifiani B., Lee, Sean B.

“…Desmoplastic Small Round Cell Tumor (DSRCT) is a rare and aggressive form of pediatric cancer caused by a translocation between chromosomes 11 and 22, creating…”
Get full text

Abstract 3529: EWSR1-WT1 isoform selectivity, DNA binding, and druggable targets: unpacking the biology of desmoplastic small round cell tumor by Magrath, Justin W., Goldberg, Ilon A., Hartono, Alifiani B., Lee, Sean B.

“…Desmoplastic small round cell tumor (DSRCT) is a rare pediatric cancer caused by the EWSR1-WT1 fusion gene. No targeted therapies have been established and…”
Get full text

Abstract 2849: Palbociclib as a novel therapeutic for desmoplastic small round cell tumor by Magrath, Justin W., Sampath, Shruthi Sanjitha, Flinchum, Dane A., Hartono, Alifiani B., Goldberg, Ilon N., Boehling, Julia R., Savkovic, Suzana D., Lee, Sean B.

“…Desmoplastic small round cell tumor (DSRCT) is an aggressive, pediatric cancer caused by the EWSR1-WT1 fusion oncoprotein. Targeted therapies are lacking and…”
Get full text

Abstract 3583: Enzalutamide and flutamide induce cytotoxicity in desmoplastic small round cell tumor independent of the androgen receptor by Magrath, Justin W., Goldberg, Ilon N., Truong, Danh D., Hartono, Alifinai B., Sampath, Shruthi Sanjitha, Jackson, Chandler E., Ghosh, Anushka, Cardin, Derrick L., Zhang, Haitao, Ludiwg, Joseph A., Lee, Sean B.

“…Desmoplastic Small Round Cell Tumor (DSRCT) is a rare, pediatric cancer caused by the EWSR1::WT1 fusion protein. DSRCT predominantly occurs in males, which…”
Get full text