Insulin-like growth factor-1 stimulates vascular smooth muscle cell proliferation in rat aorta in vivo

IGF-I is a mitogen for vascular smooth muscle cells (SMC) in vitro and enhances SMC proliferation in vivo in diabetic rats. In this study, we examined the effect of IGF-I on SMC proliferation in vivo in normal rats. Recombinant human IGF-I (0.87 and 3.1 mg/kg/day), was infused via osmotic minipumps...

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Published in:	Growth hormone & IGF research Vol. 8; no. 4; pp. 299 - 303
Main Authors:	Chen, Y., Capron, L., Magnusson, J.O., Wallby, L.A., Arnqvist, H.J.
Format:	Journal Article
Language:	English
Published:	Scotland Elsevier Ltd 01-08-1998
Subjects:	Animals Body Weight - drug effects Cell Division - drug effects DNA - drug effects DNA - metabolism Dose-Response Relationship, Drug Humans Infusion Pumps Insulin-Like Growth Factor I - metabolism Insulin-Like Growth Factor I - pharmacology Male Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - injuries Rats Rats, Sprague-Dawley Recombinant Proteins - pharmacology
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Summary:	IGF-I is a mitogen for vascular smooth muscle cells (SMC) in vitro and enhances SMC proliferation in vivo in diabetic rats. In this study, we examined the effect of IGF-I on SMC proliferation in vivo in normal rats. Recombinant human IGF-I (0.87 and 3.1 mg/kg/day), was infused via osmotic minipumps in normal rats starting 3 days before they were subjected to arotic injury with a balloon catheter. IGF-I at an infusion rate of 3.1 mg/kg/day caused a significant increase in 3H-thymidine incorporation into DNA (+53%, P<0.01) in the rat aortic intima-media 2 days after injury and DNA content (+13%, P<0.05) after 11 days. The elastin and collagen contents were not changed by IGF-I infusion after 11 days. Body weight increased slightly while blood glucose was not affected. At an infusion rate of 0.87 mg/kg/day, IGF-I had no significant effects. These results suggest that circulating levels of IGF-I can stimulate SMC proliferation in vivo in normal rats but only at high concentrations.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1096-6374 1532-2238
DOI:	10.1016/S1096-6374(98)80125-1