Search Results - "Magnuson, David S."

Spinal Interneurons as Gatekeepers to Neuroplasticity after Injury or Disease by Zholudeva, Lyandysha V, Abraira, Victoria E, Satkunendrarajah, Kajana, McDevitt, Todd C, Goulding, Martyn D, Magnuson, David S K, Lane, Michael A

“…Spinal interneurons are important facilitators and modulators of motor, sensory, and autonomic functions in the intact CNS. This heterogeneous population of…”
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N-acetylcysteine amide preserves mitochondrial bioenergetics and improves functional recovery following spinal trauma by Patel, Samir P., Sullivan, Patrick G., Pandya, Jignesh D., Goldstein, Glenn A., VanRooyen, Jenna L., Yonutas, Heather M., Eldahan, Khalid C., Morehouse, Johnny, Magnuson, David S.K., Rabchevsky, Alexander G.

“…Mitochondrial dysfunction is becoming a pivotal target for neuroprotective strategies following contusion spinal cord injury (SCI) and the pharmacological…”
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Combining clinically common drugs with hindlimb stretching in spinal cord injured rodents by Forston, Morgan J., Jordan, Savannah L., Cesarz, Greta M., Burke, Darlene A., Shum-Siu, Alice, Petruska, Jeffrey C., Magnuson, David S. K.

“…Study design Preclinical pilot study. Objectives To explore peripheral and central nociceptive mechanisms that contribute to muscle stretch-induced locomotor…”
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Broad opioid antagonism amplifies disruption of locomotor function following therapy-like hindlimb stretching in spinal cord injured rats by States, Gregory J. R., Keller, Anastasia, Shum-Siu, Alice, Petruska, Jeffrey C., Magnuson, David S. K.

“…Study design Preclinical pilot study. Objectives To test the hypothesis that spinal opioidergic circuitry contributes to muscle stretch-induced locomotor…”
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Silencing long-descending inter-enlargement propriospinal neurons improves hindlimb stepping after contusive spinal cord injuries by Shepard, Courtney T, Brown, Brandon L, Van Rijswijck, Morgan A, Zalla, Rachel M, Burke, Darlene A, Morehouse, Johnny R, Riegler, Amberly S, Whittemore, Scott R, Magnuson, David S K

“…Spinal locomotor circuitry is comprised of rhythm generating centers, one for each limb, that are interconnected by local and long-distance propriospinal…”
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A comparison of passive hindlimb cycling and active upper-limb exercise provides new insights into systolic dysfunction after spinal cord injury by DeVeau, Kathryn M, Harman, Kathryn A, Squair, Jordan W, Krassioukov, Andrei V, Magnuson, David S K, West, Christopher R

“…Active upper-limb and passive lower-limb exercise are two interventions used in the spinal cord injury (SCI) population. Although the global cardiac responses…”
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Treadmill-Based Gait Kinematics in the Yucatan Mini Pig by Boakye, Maxwell, Morehouse, Johnny, Ethridge, Jay, Burke, Darlene A, Khattar, Nicolas K, Kumar, Chitra, Manouchehri, Neda, Streijger, Femke, Reed, Robert, Magnuson, David S K, Sherwood, Leslie, Kwon, Brian K, Howland, Dena R

“…Yucatan miniature pigs (YMPs) are similar to humans in spinal cord size as well as physiological and neuroanatomical features, making them a useful model for…”
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Spinal Cord Injury Causes Systolic Dysfunction and Cardiomyocyte Atrophy by Squair, Jordan W, DeVeau, Kathryn M, Harman, Kathryn A, Poormasjedi-Meibod, Malihe-Sadat, Hayes, Brian, Liu, Jie, Magnuson, David S K, Krassioukov, Andrei V, West, Christopher R

“…Individuals with spinal cord injury (SCI) have been shown to exhibit systolic, and to a lesser extent, diastolic cardiac dysfunction. However, previous reports…”
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FAIR SCI Ahead: The Evolution of the Open Data Commons for Pre-Clinical Spinal Cord Injury Research by Fouad, Karim, Bixby, John L, Callahan, Alison, Grethe, Jeffrey S, Jakeman, Lyn B, Lemmon, Vance P, Magnuson, David S K, Martone, Maryann E, Nielson, Jessica L, Schwab, Jan M, Taylor-Burds, Carol, Tetzlaff, Wolfram, Torres-Espin, Abel, Ferguson, Adam R

“…Over the last 5 years, multiple stakeholders in the field of spinal cord injury (SCI) research have initiated efforts to promote publications standards and…”
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Functional consequences of ethidium bromide demyelination of the mouse ventral spinal cord by Kuypers, Nicholas J., James, Kurtis T., Enzmann, Gaby U., Magnuson, David S.K., Whittemore, Scott R.

“…Ethidium bromide (EB) has been extensively used in the rat as a model of spinal cord demyelination. However, this lesion has not been addressed in the adult…”
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Reversible silencing of lumbar spinal interneurons unmasks a task-specific network for securing hindlimb alternation by Pocratsky, Amanda M., Burke, Darlene A., Morehouse, Johnny R., Beare, Jason E., Riegler, Amberly S., Tsoulfas, Pantelis, States, Gregory J. R., Whittemore, Scott R., Magnuson, David S. K.

“…Neural circuitry in the lumbar spinal cord governs two principal features of locomotion, rhythm and pattern, which reflect intra- and interlimb movement. These…”
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Evidence That the Central Nervous System Can Induce a Modification at the Neuromuscular Junction That Contributes to the Maintenance of a Behavioral Response by Hoy, Kevin C, Strain, Misty M, Turtle, Joel D, Lee, Kuan H, Huie, J Russell, Hartman, John J, Tarbet, Megan M, Harlow, Mark L, Magnuson, David S K, Grau, James W

“…Neurons within the spinal cord are sensitive to environmental relations and can bring about a behavioral modification without input from the brain. For…”
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Challenges of animal models in SCI research: Effects of pre-injury task-specific training in adult rats before lesion by May, Zacnicte, Fouad, Karim, Shum-Siu, Alice, Magnuson, David S.K.

“…•Two different models of spinal cord injury and task-specific re-training are used.•Activity/training pre-SCI is found to influence post-injury…”
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Introduction to the Special Issue on Locomotor Rehabilitation after Spinal Cord Injury by Magnuson, David S K, Dietrich, W Dalton

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Data Safety Monitoring Boards: Overview of Structure and Role in Spinal Cord Injury Studies by Blight, Andrew R, Guest, James D, Hamer, James, Hsieh, Jane T C, Jones, Linda, Magnuson, David S K, Pfleeger, Kimberley

“…This paper provides an overview of the history, composition, organization, responsibilities, and regulatory requirements of Data Safety Monitoring Boards…”
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Rolipram attenuates acute oligodendrocyte death in the adult rat ventrolateral funiculus following contusive cervical spinal cord injury by Whitaker, Christopher M., Beaumont, Eric, Wells, Michael J., Magnuson, David S.K., Hetman, Michal, Onifer, Stephen M.

“…Rolipram, an inhibitor of phosphodiesterase 4 (PDE4) proteins that hydrolyze cAMP, increases axonal regeneration following spinal cord injury (SCI). Recent…”
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Swimming as a Model of Task-Specific Locomotor Retraining After Spinal Cord Injury in the Rat by Magnuson, David S. K., Smith, Rebecca R., Brown, Edward H., Enzmann, Gaby, Angeli, Claudia, Quesada, Peter M., Burke, Darlene

“…Background. The authors have shown that rats can be retrained to swim after a moderately severe thoracic spinal cord contusion. They also found that…”
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Protocol for rapid onset of mobilisation in patients with traumatic spinal cord injury (PROMPT-SCI) study: a single-arm proof-of-concept trial of early in-bed leg cycling following acute traumatic spinal cord injury by Mac-Thiong, Jean-Marc, Richard-Denis, Andreane, Petit, Yvan, Bernard, Francis, Barthélemy, Dorothy, Dionne, Antoine, Magnuson, David S K

“…IntroductionActivity-based therapy (ABT) is an important aspect of rehabilitation following traumatic spinal cord injury (SCI). Unfortunately, it has never…”
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Initiation of segmental locomotor-like activities by stimulation of ventrolateral funiculus in the neonatal rat by Cheng, Jianguo, Magnuson, David S. K.

“…Descending control is critically important for the generation of locomotor activities. Yet, our understanding of the descending control system of locomotion is…”
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Cervical response among ascending ventrolateral funiculus pathways of the neonatal rat by Reed, William R, Magnuson, David S.K

“…Abstract Propriospinal pathways, consisting of axons from interneurons that project to other spinal segments, have been implicated as likely candidates to…”
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