Search Results - "Magis, Wendy"

Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells by DeWitt, Mark A, Magis, Wendy, Bray, Nicolas L, Wang, Tianjiao, Berman, Jennifer R, Urbinati, Fabrizia, Heo, Seok-Jin, Mitros, Therese, Muñoz, Denise P, Boffelli, Dario, Kohn, Donald B, Walters, Mark C, Carroll, Dana, Martin, David I K, Corn, Jacob E

“…Genetic diseases of blood cells are prime candidates for treatment through ex vivo gene editing of CD34 hematopoietic stem/progenitor cells (HSPCs), and a…”
Get more information

CRISPR-Cas9 interrogation of a putative fetal globin repressor in human erythroid cells by Chung, Jennifer E, Magis, Wendy, Vu, Jonathan, Heo, Seok-Jin, Wartiovaara, Kirmo, Walters, Mark C, Kurita, Ryo, Nakamura, Yukio, Boffelli, Dario, Martin, David I K, Corn, Jacob E, DeWitt, Mark A

“…Sickle Cell Disease and ß-thalassemia, which are caused by defective or deficient adult ß-globin (HBB) respectively, are the most common serious genetic blood…”
Get full text

Deep sequencing reveals novel microRNAs and regulation of microRNA expression during cell senescence by Dhahbi, Joseph M, Atamna, Hani, Boffelli, Dario, Magis, Wendy, Spindler, Stephen R, Martin, David I K

“…In cell senescence, cultured cells cease proliferating and acquire aberrant gene expression patterns. MicroRNAs (miRNAs) modulate gene expression through…”
Get full text

Nuclear Relocation of a Transactivator Subunit Precedes Target Gene Activation by Francastel, Claire, Magis, Wendy, Groudine, Mark

“…Murine erythroleukemia (MEL) cells are a model system to study reorganization of the eukaryotic nucleus during terminal differentiation. Upon chemical…”
Get full text

The Chicken β-Globin 5′HS4 Boundary Element Blocks Enhancer-Mediated Suppression of Silencing by Walters, Mark C., Fiering, Steven, Bouhassira, Eric E., Scalzo, David, Goeke, Scott, Magis, Wendy, Garrick, David, Whitelaw, Emma, Martin, David I. K.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

An Upstream Activator of Transcription Coordinately Increases the Level and Epigenetic Stability of Gene Expression by Magis, Wendy, Fiering, Steven, Groudine, Mark, David I. K. Martin

“…The mouse metallothionein-I (mMT-I) promoter is activated by the metal response element-binding transcription factor (MTF), which binds metal response elements…”
Get full text

High-level correction of the sickle mutation is amplified in vivo during erythroid differentiation by Magis, Wendy, DeWitt, Mark A., Wyman, Stacia K., Vu, Jonathan T., Heo, Seok-Jin, Shao, Shirley J., Hennig, Finn, Romero, Zulema G., Campo-Fernandez, Beatriz, Said, Suzanne, McNeill, Matthew S., Rettig, Garrett R., Sun, Yongming, Wang, Yu, Behlke, Mark A., Kohn, Donald B., Boffelli, Dario, Walters, Mark C., Corn, Jacob E., Martin, David I.K.

“…A point mutation in sickle cell disease (SCD) alters one amino acid in the β-globin subunit of hemoglobin, with resultant anemia and multiorgan damage that…”
Get full text

Enhancers Increase the Probability But not the Level of Gene Expression by Walters, Mark C., Fiering, Steven, Eidemiller, Jeff, Magis, Wendy, Groudine, Mark, David I. K. Martin

“…We have studied enhancer function in transient and stable expression assays in mammalian cells by using systems that distinguish expressing from nonexpressing…”
Get full text

Transcriptional enhancers act in cis to suppress position-effect variegation by Walters, M C, Magis, W, Fiering, S, Eidemiller, J, Scalzo, D, Groudine, M, Martin, D I

“…We have examined the basis of enhancer effects on gene expression by altering the action of enhancers on expression of a stably integrated reporter gene. We…”
Get full text

The chicken beta-globin 5'HS4 boundary element blocks enhancer-mediated suppression of silencing by Walters, M C, Fiering, S, Bouhassira, E E, Scalzo, D, Goeke, S, Magis, W, Garrick, D, Whitelaw, E, Martin, D I

“…A constitutive DNase I-hypersensitive site 5' of the chicken beta-globin locus, termed 5'HS4 or cHS4, has been shown to insulate a promoter from the effect of…”
Get full text

HMG-I Binds to GATA Motifs: Implications for an HPFH Syndrome by Magis, W., Martin, D.I.K.

“…We have examined binding of the nuclear protein HMG-I to the human γ-globin promoter. We find that HMG-I binds preferentially to the more 3′ of a pair of GATA…”
Get full text

γ Gene Promoter and Enhancer Structure in Seattle Variant of Hereditary Persistence of Fetal Hemoglobin by Gelinas, Richard E., Rixon, Mark, Magis, Wendy, Stamatoyannopoulos, George

“…A variant of hereditary persistence of fetal hemoglobin (HPFH), first described in a patient from Seattle, was studied by structural analysis of the γ-globin…”
Get full text