Search Results - "Maggs, J.L."

The bioactivation of amodiaquine by human polymorphonuclear leucocytes in vitro: Chemical mechanisms and the effects of fluorine substitution by Tingle, M.D., Jewell, H., Maggs, J.L., O'Neill, P.M., Park, B.K.

“…Amodiaquine, a 4-aminoquinoline antimalarial, has been associated with hepatitis and agranulocytosis in humans. Drug hypersensitivity reactions, especially…”
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Structural basis for the haemotoxicity of dapsone: the importance of the sulphonyl group by Mahmud, R., Tingle, M.D., Maggs, J.L., Cronin, M.T.D., Dearden, J.C., Park, B.K.

“…The structural basis of dapsone (4,4′-diaminodiphenyl sulphone) haemotoxicity has been determined by investigation of the in vitro bioactivation of a series of…”
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Cortisol metabolism by human liver in vitro--I. Metabolite identification and inter-individual variability by Abel, S M, Maggs, J L, Back, D J, Park, B K

“…The measurement of urinary 6 beta-hydroxycortisol (6 beta-OHF) has been widely used as a non-invasive clinical test to detect cytochrome P450 induction…”
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Cortisol metabolism in vitro--II. Species difference by Abel, S M, Back, D J, Maggs, J L, Park, B K

“…It has been suggested that cortisol 6 beta-hydroxylase activity specifically reflects cytochrome P4503A (CYP3A) levels in the liver. However, we have…”
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The proestrogen methoxychlor is active in a yeast oestrogenicity assay in the absence of metabolism by Elsby, R., Maggs, J.L., Ashby, J., Park, B.K.

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Dexamethasone metabolism in vitro: Species differences by Tomlinson, E.S., Maggs, J.L., Park, B.K., Back, D.J.

“…Dexamethasone (DEX) is extensively metabolized to 6-hydroxyDEX (6OH-DEX) and side-chain cleaved metabolites in human liver both in vitro and in vivo with…”
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Risky Business: The Paradoxical Meaning of Problem Behavior for Young Adolescents by Maggs, Jennifer L

“…Examined concurrent and longitudinal relations among adolescents' problem behavior (PB), self-image, and peer relations. Analyses showed age increases…”
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In vitro metabolism of dexamethasone (DEX) in human liver and kidney: The involvement of CYP3a4 and CYP17 (17,20 LYASE) and molecular modelling studies by Tomlinson, E.S., Lewis, D.F.V., Maggs, J.L., Kroemer, H.K., Park, B.K., Back, D.J.

“…Dexamethasone (DEX) has previously been shown to be extensively metabolised to 6-hydroxylated and side-chain cleaved metabolites in human liver in vitro…”
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Drug-protein conjugates--XIV. Mechanisms of formation of protein-arylating intermediates from amodiaquine, a myelotoxin and hepatotoxin in man by Maggs, J L, Tingle, M D, Kitteringham, N R, Park, B K

“…The enzymic and non-enzymic formation of protein-arylating intermediates from amodiaquine (AQ,7-chloro-4-(3'-diethylamino-4'-hydroxyanilino) quinoline), an…”
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The sexually differentiated metabolism of [6,7-3H]17 beta-oestradiol in rats: male-specific 15 alpha- and male-selective 16 alpha-hydroxylation and female-selective catechol formation by Maggs, J L, Morgan, P, Park, B K

“…The oxygenated-metabolite profiles of exogenous 17 beta-oestradiol (E2) in adult male and female Wistar rats have been characterized and major sex-dependent…”
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Cortisol metabolism by human liver in vitro--IV. Metabolism of 9 alpha-fluorocortisol by human liver microsomes and cytosol by Abel, S M, Back, D J, Maggs, J L, Park, B K

“…The oxidative and reductive biotransformations of 9 alpha-fluorocortisol (fluorocortisol) by human liver microsomes and cytosol have been characterized. 9…”
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Oxidative dehalogenation of 2-fluoro-17 alpha-ethynyloestradiol in vivo. A distal structure-metabolism relationship of 17 alpha-ethynylation by Morgan, P, Maggs, J L, Page, P C, Park, B K

“…Metabolic activation to catechols and their oxidation products is variously considered to contribute to the genotoxic, cytotoxic, transforming and…”
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Immunogenicity of amodiaquine in the rat by Clarke, J B, Maggs, J L, Kitteringham, N R, Park, B K

“…Amodiaquine is an antimalarial drug that has been associated with adverse reactions which may be immune mediated. Specific IgG anti-amodiaquine antibodies were…”
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The metabolism of 2- and 4-fluoro-17 beta-oestradiol in the rat and its implications for oestrogen carcinogenesis by Morgan, P, Maggs, J L, Bulman-Page, P C, Hussain, F, Park, B K

“…2-Fluoro-[6,7-3H]17 beta-oestradiol([3H]2-FE2) and 4-fluoro-[6,7-3H]17 beta-oestradiol([3H]4-FE2) were synthesized by the fluorination and reduction of…”
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The effect of 2,2′-substitution on the metabolism and toxicity of dapsone in vitro and in vivo by Tingle, M.D, Mahmud, R, Maggs, J.L, Hawley, S, Coleman, M.D, Ward, S.A, Park, B.K

“…The effect of 2,2′-substitution with fluorine, methyl or trifluoromethyl groups on the toxicity, metabolism and pharmacological activity of dapsone has been…”
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Structure-metabolism relationships of ring-A halogenated analogues of 17 alpha-ethynyloestradiol by Bonham, N M, Maggs, J L, Bulman-Page, P C, Park, B K

“…The metabolic fates of 2-chloro-, 2-bromo-, 4-bromo- and 2-iodo-17 alpha-ethynyloestradiol (EE2) in rats were determined. 6,7-3H-labelled analogues (0.1-2.0…”
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The metabolism of 2,4-dibromo [6,7-3H]17 beta-oestradiol in the rat: ring-A dibromination blocks male-specific 15 alpha-hydroxylation and catechol formation by Maggs, J L, Hussain, F, Page, P C, Park, B K

“…The metabolism in the rat of 2,4-dibromo-17 beta-oestradiol (2,4-DBE2), a compound of potential use for tumour imaging and assessment, has been studied…”
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Drug-protein conjugates--XVI. Studies of sorbinil metabolism: formation of 2-hydroxysorbinil and unstable protein conjugates by Maggs, J L, Park, B K

“…The metabolism of sorbinil [+)6-fluoro-spiro (chroman-4, 4'-imidazolidine)-2',5' dione), an aldose reductase inhibitor associated with immunological adverse…”
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Autoxidative formation of a chemically reactive intermediate from amodiaquine, a myelotoxin and hepatotoxin in man by Maggs, J L, Kitteringham, N R, Breckenridge, A M, Park, B K

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Drug-protein conjugates--VIII. The metabolic fate of the dinitrophenyl hapten conjugated to albumin by Kitteringham, N R, Maggs, J L, Newby, S, Park, B K

“…Dinitrofluorobenzene has been used as a model chemically reactive metabolite to investigate factors which determine the fate of drug-protein conjugates formed…”
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