Search Results - "Maggiolo, Ailiena O"

Structural Characterization of Two CO Molecules Bound to the Nitrogenase Active Site by Buscagan, Trixia M., Perez, Kathryn A., Maggiolo, Ailiena O., Rees, Douglas C., Spatzal, Thomas

“…As an approach towards unraveling the nitrogenase mechanism, we have studied the binding of CO to the active‐site FeMo‐cofactor. CO is not only an inhibitor of…”
Get full text

Structural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5 by Mitchell, Andrew J, Zhu, Qin, Maggiolo, Ailiena O, Ananth, Nikhil R, Hillwig, Matthew L, Liu, Xinyu, Boal, Amie K

“…WelO5 is an iron- and 2-oxoglutarate-dependent halogenase involved in welwitindolinone biosynthesis. A collection of X-ray crystal structures reveals the…”
Get full text

Structural consequences of turnover-induced homocitrate loss in nitrogenase by Warmack, Rebeccah A., Maggiolo, Ailiena O., Orta, Andres, Wenke, Belinda B., Howard, James B., Rees, Douglas C.

“…Nitrogenase catalyzes the ATP-dependent reduction of dinitrogen to ammonia during the process of biological nitrogen fixation that is essential for sustaining…”
Get full text

Structural Basis for Superoxide Activation of Flavobacterium johnsoniae Class I Ribonucleotide Reductase and for Radical Initiation by Its Dimanganese Cofactor by Rose, Hannah R, Ghosh, Manas K, Maggiolo, Ailiena O, Pollock, Christopher J, Blaesi, Elizabeth J, Hajj, Viviane, Wei, Yifeng, Rajakovich, Lauren J, Chang, Wei-chen, Han, Yilin, Hajj, Mariana, Krebs, Carsten, Silakov, Alexey, Pandelia, Maria-Eirini, Bollinger, J. Martin, Boal, Amie K

“…A ribonucleotide reductase (RNR) from Flavobacterium johnsoniae (Fj) differs fundamentally from known (subclass a–c) class I RNRs, warranting its assignment to…”
Get full text

Intradimeric Walker A ATPases: Conserved Features of A Functionally Diverse Family by Maggiolo, Ailiena O., Mahajan, Shivansh, Rees, Douglas C., Clemons, William M.

“…Graphical Abstract [Display omitted] •Intradimeric Walker A (IWA) proteins are a subset of homodimeric Walker A ATPases with diverse functions.•IWA proteins…”
Get full text

Engineering RNA export for measurement and manipulation of living cells by Horns, Felix, Martinez, Joe A., Fan, Chengcheng, Haque, Mehernaz, Linton, James M., Tobin, Victoria, Santat, Leah, Maggiolo, Ailiena O., Bjorkman, Pamela J., Lois, Carlos, Elowitz, Michael B.

“…A system for programmable export of RNA molecules from living cells would enable both non-destructive monitoring of cell dynamics and engineering of cells…”
Get full text

Structurally derived universal mechanism for the catalytic cycle of the tail-anchored targeting factor Get3 by Fry, Michelle Y., Najdrová, Vladimíra, Maggiolo, Ailiena O., Saladi, Shyam M., Doležal, Pavel, Clemons, William M.

“…Tail-anchored (TA) membrane proteins, accounting for roughly 2% of proteomes, are primarily targeted posttranslationally to the endoplasmic reticulum membrane…”
Get full text

Optimized Substrate Positioning Enables Switches in the C–H Cleavage Site and Reaction Outcome in the Hydroxylation–Epoxidation Sequence Catalyzed by Hyoscyamine 6β-Hydroxylase by Wenger, Eliott S., Martinie, Ryan J., Ushimaru, Richiro, Pollock, Christopher J., Sil, Debangsu, Li, Aaron, Hoang, Nhi, Palowitch, Gavin M., Graham, Brandt P., Schaperdoth, Irene, Burke, Evan J., Maggiolo, Ailiena O., Chang, Wei-chen, Allen, Benjamin D., Krebs, Carsten, Silakov, Alexey, Boal, Amie K., Bollinger, J. Martin

“…Hyoscyamine 6β-hydroxylase (H6H) is an iron­(II)- and 2-oxoglutarate-dependent (Fe/2OG) oxygenase that produces the prolifically administered antinausea drug,…”
Get full text

An endogenous dAMP ligand in Bacillus subtilis class Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP by Parker, Mackenzie J., Maggiolo, Ailiena O., Thomas, William C., Kim, Albert, Meisburger, Steve P., Ando, Nozomi, Boal, Amie K., Stubbe, JoAnne

“…The high fidelity of DNA replication and repair is attributable, in part, to the allosteric regulation of ribonucleotide reductases (RNRs) that maintains…”
Get full text

Structures of Class Id Ribonucleotide Reductase Catalytic Subunits Reveal a Minimal Architecture for Deoxynucleotide Biosynthesis by Rose, Hannah R, Maggiolo, Ailiena O, McBride, Molly J, Palowitch, Gavin M, Pandelia, Maria-Eirini, Davis, Katherine M, Yennawar, Neela H, Boal, Amie K

“…Class I ribonucleotide reductases (RNRs) share a common mechanism of nucleotide reduction in a catalytic α subunit. All RNRs initiate catalysis with a thiyl…”
Get full text

Chemodivergent C(sp3)–H and C(sp2)–H cyanomethylation using engineered carbene transferases by Zhang, Juner, Maggiolo, Ailiena O., Alfonzo, Edwin, Mao, Runze, Porter, Nicholas J., Abney, Nayla M., Arnold, Frances H.

“…The ubiquity of C–H bonds presents an opportunity to efficiently elaborate and build complexity in organic molecules. Methods for selective functionalization,…”
Get full text

Structural Characterization of Two CO Molecules Bound to the Nitrogenase Active Site by Buscagan, Trixia M., Perez, Kathryn A., Maggiolo, Ailiena O., Rees, Douglas C., Spatzal, Thomas

“…As an approach towards unraveling the nitrogenase mechanism, we have studied the binding of CO to the active‐site FeMo‐cofactor. CO is not only an inhibitor of…”
Get full text

Chemodivergent C(sp3)–H and C(sp2)–H cyanomethylation using engineered carbene transferases by Zhang, Juner, Maggiolo, Ailiena O., Alfonzo, Edwin, Mao, Runze, Porter, Nicholas J., Abney, Nayla M., Arnold, Frances H.

“…Not provided…”
Get full text