Search Results - "Magesh, R."

Analysis of Differentially Expressed Genes and Molecular Pathways in Familial Hypercholesterolemia Involved in Atherosclerosis: A Systematic and Bioinformatics Approach by Udhaya Kumar, S, Thirumal Kumar, D, Bithia, R, Sankar, Srivarshini, Magesh, R, Sidenna, Mariem, George Priya Doss, C, Zayed, Hatem

“…Familial hypercholesterolemia (FH) is one of the major risk factor for the progression of atherosclerosis and coronary artery disease. This study focused on…”
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Molecular insights of the G2019S substitution in LRRK2 kinase domain associated with Parkinson's disease: A molecular dynamics simulation approach by Agrahari, Ashish Kumar, Doss, George Priya C., Siva, R., Magesh, R., Zayed, Hatem

“…•Impact of G2019S substitution in the kinase domain of LRRK2 protein.•Long run of molecular dynamics simulation.•Affects the dynamics and…”
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Investigation on catalytic activity of CuO/La2O3, CuO/Gd2O3 and CuO/La2O3/Gd2O3 nanocatalysts prepared via novel two step approach by Sankaran, A., Kumaraguru, K., Balraj, B., Sridevi, A., Magesh, R.

“…[Display omitted] •CuO/La2O3/Gd2O3 nanocatalysts was prepared via novel two step synthesis approach.•The FESEM analysis confirmed the flake like structure of…”
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Exploring natural products library to identify potential inhibitors targeting isoniazid-resistant tuberculosis by N, Madhana Priya, C, George Priya Doss, R, Magesh

“…Mycobacterium tuberculosis (MTB) causing tuberculosis (TB) infection is a leading source of illness and death in developing nations, and the emergence of…”
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Biosynthesis of Silver Nanoparticles from Endophytic Fungi, and its Cytotoxic Activity by Janakiraman, Vardhana, Govindarajan, Kathiravan, C R, Magesh

“…Nanoparticle research is currently an area of intense scientific interest due to a wide variety of potential applications in biomedical, optical, and…”
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Elucidating the functional impact of G137V and G144R variants in Maroteaux Lamy’s Syndrome by Molecular Dynamics Simulation by Madhana Priya, N., Archana Pai, P., Thirumal Kumar, D., Gnanasambandan, R., Magesh, R.

“…Mucopolysaccharidoses VI (Maroteaux Lamy syndrome) is a metabolic disorder due to the loss of enzyme activity of N -acetyl galactosamine-4-sulphatase arising…”
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A computational approach to analyse the amino acid variants of GLB1 protein causing GM1 Gangliosidosis by Priyanka, K., Madhana Priya, N., Magesh, R.

“…Lysosomal storage diseases comprise different forms of autosomal recessive disorders from which GM1 gangliosidosis has categorized by the accumulation of…”
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Development of sustainable aluminum alloy‑tungsten carbide hybrid composites using industrial waste - An experimental analysis by N., Ramasamy, M., Prakash, B., Prabhu, K., Viswanathan, A., Gowtham, R., Magesh, T., Arunkumar

“…The research article focuses on the development of aluminum alloy 6061 sustainable composites with the utilization of industrial waste through the use of the…”
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Influence of V54M mutation in giant muscle protein titin: a computational screening and molecular dynamics approach by Thirumal Kumar, D., George Priya Doss, C., Sneha, P., Tayubi, Iftikhar Aslam, Siva, R., Chakraborty, Chiranjib, Magesh, R.

“…Recent genetic studies have revealed the impact of mutations in associated genes for cardiac sarcomere components leading to dilated cardiomyopathy (DCM). The…”
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A natural anticancer pigment,Pheophytin a,from a seagrass acts as a high affinity human mitochondrial translocator protein (TSPO) ligand, in silico, to reduce mitochondrial membrane Potential (∆ψmit) in adenocarcinomic A549 cells by Shailaja, V.L., Christina, V.S., Mohanapriya, C.D., Sneha, P., Lakshmi Sundaram, R., Magesh, R., George Priya Doss, C., Gnanambal, K. Mary Elizabeth

“…•We prove that the accessory photosynthetic pigment, Pheophytin a made lung cancer cell lines, A549 to undergo apoptotic mode of death.•The compound initiated…”
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Understanding the activating mechanism of the immune system against COVID-19 by Traditional Indian Medicine: Network pharmacology approach by Thirumal Kumar, D, Shree Devi, M S, Udhaya Kumar, S, Sherlin, Annie, Mathew, Aishwarya, Lakshmipriya, M, Sathiyarajeswaran, P, Gnanasambandan, R, Siva, R, Magesh, R, George Priya Doss, C

“…Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) transmissions are occurring rapidly; it is raising the alarm around the globe. Though vaccines are…”
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Network analysis of transcriptomics data for the prediction and prioritization of membrane-associated biomarkers for idiopathic pulmonary fibrosis (IPF) by bioinformatics approach by Mishra, Smriti, Shah, Mohammad Imran, Udhaya Kumar, S, Thirumal Kumar, D, Gopalakrishnan, Chandrasekhar, Al-Subaie, Abeer Mohammed, Magesh, R, George Priya Doss, C, Kamaraj, Balu

“…Idiopathic pulmonary fibrosis (IPF) is a rare yet crucial persistent lung disorder that actuates scarring of lung tissues, which makes breathing difficult…”
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Computational screening and structural analysis of Gly201Arg and Gly201Asp missense mutations in human cyclin-dependent kinase 4 protein by Thirumal Kumar, D, Shaikh, Nishaat, Bithia, R, Karthick, V, George Priya Doss, C, Magesh, R

“…The regulatory proteins, cyclins, and cyclin-dependent kinases (CDKs) control the cell cycle progression. CDK4 gene mutations are associated with certain…”
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Controlling cell proliferation by targeting cyclin-dependent kinase 6 using drug repurposing approach by Madhana Priya, N, Balasundaram, Ambritha, Sidharth Kumar, N, Udhaya Kumar, S, Thirumal Kumar, D, Magesh, R, Zayed, Hatem, George Priya Doss, C

“…Cyclin-dependent kinase 6 (CDK6) is an essential kinase in cell cycle progression, which is a viable target for inhibitors in various malignancies, including…”
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Fall in elderly during COVID-19 pandemic: A case report and review by R Magesh, Phani Krishna Machiraju, Neetu Mariam Alex

“…Coronavirus disease-19 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 primarily affects the lung resulting in acute lung injury, which…”
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A review of novel coronavirus disease (COVID-19): based on genomic structure, phylogeny, current shreds of evidence, candidate vaccines, and drug repurposing by Kumar, S. Udhaya, Priya, N. Madhana, Nithya, S. R., Kannan, Priyanka, Jain, Nikita, Kumar, D. Thirumal, Magesh, R., Younes, Salma, Zayed, Hatem, Doss, C. George Priya

“…Coronavirus disease (COVID-19) pandemic is instigated by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As of March 13, 2021, more than 118.9…”
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In silico profiling and structural insights of missense mutations in RET protein kinase domain by molecular dynamics and docking approach by George Priya Doss, C, Rajith, B, Chakraboty, Chiranjib, Balaji, V, Magesh, R, Gowthami, B, Menon, Sneha, Swati, M, Trivedi, Manjari, Paul, Jasmine, Vasan, Richa, Das, Maitreya

“…A major challenge remaining in drug design efforts towards protein kinase is due to the development of drug resistance initiated by the missense mutations in…”
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Investigating mutations at the hotspot position of the ERBB2 and screening for the novel lead compound to treat breast cancer - a computational approach by Thirumal Kumar, D, Udhaya Kumar, S, Magesh, R, George Priya Doss, C

“…Membrane proteins are the most common types of cancer that are active in the prognosis. Membrane proteins are a distinguishing characteristic of a cancer cell…”
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Analyzing the Effect of V66M Mutation in BDNF in Causing Mood Disorders: A Computational Approach by Sneha, P, Thirumal Kumar, D, Saini, Sugandhi, Kajal, Kreeti, Magesh, R, Siva, R, George Priya Doss, C

“…Mental disorders or mood disorders are prevalent globally irrespective of region, race, and ethnic groups. Of the types of mood disorders, major depressive…”
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Computational Identification of Pathogenic Associated nsSNPs and its Structural Impact in UROD Gene: A Molecular Dynamics Approach by George Priya Doss, C., Magesh, R.

“…Uroporphyrinogen decarboxylase is a cytosolic enzyme involved in the biosynthetic pathway of heme production. Decreased activity of this enzyme results in…”
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