Search Results - "Mages, Jörg"

DUSP Meet Immunology: Dual Specificity MAPK Phosphatases in Control of the Inflammatory Response by Lang, Roland, Hammer, Michael, Mages, Jorg

“…The MAPK family members p38, JNK, and ERK are all activated downstream of innate immunity's TLR to induce the production of cytokines and inflammatory…”
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Double-Stranded RNA Induces an Antiviral Defense Status in Epidermal Keratinocytes through TLR3-, PKR-, and MDA5/RIG-I-Mediated Differential Signaling by Kalali, Behnam Naderi, Kollisch, Gabriele, Mages, Jorg, Muller, Thomas, Bauer, Stefan, Wagner, Hermann, Ring, Johannes, Lang, Roland, Mempel, Martin, Ollert, Markus

“…Emerging evidence suggests an important role for human epidermal keratinocytes in innate immune mechanisms against bacterial and viral skin infections. The…”
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Autocrine IL-10 Induces Hallmarks of Alternative Activation in Macrophages and Suppresses Antituberculosis Effector Mechanisms without Compromising T Cell Immunity by Schreiber, Tanja, Ehlers, Stefan, Heitmann, Lisa, Rausch, Alexandra, Mages, Jorg, Murray, Peter J, Lang, Roland, Holscher, Christoph

“…Elevated IL-10 has been implicated in reactivation tuberculosis (TB). Since macrophages rather than T cells were reported to be the major source of IL-10 in…”
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Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock by Hammer, Michael, Mages, Jörg, Dietrich, Harald, Servatius, Angela, Howells, Norma, Cato, Andrew C B, Lang, Roland

“…Activation of the mitogen-activated protein kinase (MAPK) cascade after Toll-like receptor stimulation enables innate immune cells to rapidly activate cytokine…”
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Differential Recognition of TLR-Dependent Microbial Ligands in Human Bronchial Epithelial Cells by Mayer, Anja K, Muehmer, Mario, Mages, Jorg, Gueinzius, Katja, Hess, Christian, Heeg, Klaus, Bals, Robert, Lang, Roland, Dalpke, Alexander H

“…Bronchial epithelial cells represent the first line of defense against invading airborne pathogens. They are important contributors to innate mucosal immunity…”
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E-Cadherin Regulates Metastasis of Pancreatic Cancer In Vivo and Is Suppressed by a SNAIL/HDAC1/HDAC2 Repressor Complex by von Burstin, Johannes, Eser, Stefan, Paul, Mariel C, Seidler, Barbara, Brandl, Martina, Messer, Marlena, von Werder, Alexander, Schmidt, Annegret, Mages, Jörg, Pagel, Philipp, Schnieke, Angelika, Schmid, Roland M, Schneider, Günter, Saur, Dieter

“…Background & Aims Early metastasis is a hallmark of pancreatic ductal adenocarcinoma and responsible for >90% of pancreatic cancer death. Because little is…”
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High-resolution gene expression profiling for simultaneous kinetic parameter analysis of RNA synthesis and decay by Dölken, Lars, Ruzsics, Zsolt, Rädle, Bernd, Friedel, Caroline C, Zimmer, Ralf, Mages, Jörg, Hoffmann, Reinhard, Dickinson, Paul, Forster, Thorsten, Ghazal, Peter, Koszinowski, Ulrich H

“…RNA levels in a cell are determined by the relative rates of RNA synthesis and decay. State-of-the-art transcriptional analyses only employ total cellular RNA…”
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Distinct and Nonredundant In Vivo Functions of IFNAR on Myeloid Cells Limit Autoimmunity in the Central Nervous System by Prinz, Marco, Schmidt, Hauke, Mildner, Alexander, Knobeloch, Klaus-Peter, Hanisch, Uwe-Karsten, Raasch, Jenni, Merkler, Doron, Detje, Claudia, Gutcher, Ilona, Mages, Jörg, Lang, Roland, Martin, Roland, Gold, Ralf, Becher, Burkhard, Brück, Wolfgang, Kalinke, Ulrich

“…The action of type I interferons in the central nervous system (CNS) during autoimmunity is largely unknown. Here, we demonstrate elevated interferon beta…”
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Cellular Target Genes of Epstein-Barr Virus Nuclear Antigen 2 by MAIER, Sabine, STAFFLER, Gabriele, MAGES, Jörg, KEMPKES, Bettina, HARTMANN, Andrea, HÖCK, Julia, HENNING, Karen, GRABUSIC, Kristina, MAILHAMMER, Reinhard, HOFFMANN, Reinhard, WILMANNS, Matthias, LANG, Roland

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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SOCS3 regulates the plasticity of gp130 signaling by Murray, Peter J, Lang, Roland, Pauleau, Anne-Laure, Parganas, Evan, Takahashi, Yutaka, Mages, Jörg, Ihle, James N, Rutschman, Robert

“…Suppressor of cytokine signaling (SOCS) proteins are feedback inhibitors of the Janus kinase (JAK) and signal transducer and activator of transcription (STAT)…”
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Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells by Schmitz, Frank, Heit, Antje, Dreher, Stefan, Eisenächer, Katharina, Mages, Jörg, Haas, Tobias, Krug, Anne, Janssen, Klaus-Peter, Kirschning, Carsten J, Wagner, Hermann

“…The mammalian target of rapamycin (mTOR) can be viewed as cellular master complex scoring cellular vitality and stress. Whether mTOR controls also innate…”
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Human skin dendritic cell fate is differentially regulated by the monocyte identity factor Kruppel-like factor 4 during steady state and inflammation by Jurkin, Jennifer, PhD, Krump, Corinna, MSc, Köffel, René, PhD, Fieber, Christina, MSc, Schuster, Christopher, MD, Brunner, Patrick M., MD, Borek, Izabela, MSc, Eisenwort, Gregor, MD, Lim, Clarice, BSc(Hon), Mages, Jörg, PhD, Lang, Roland, MD, Bauer, Wolfgang, MD, Mechtcheriakova, Diana, PhD, Meshcheryakova, Anastasia, MSc, Elbe-Bürger, Adelheid, PhD, Stingl, Georg, MD, Strobl, Herbert, MD

“…Background Langerhans cell (LC) networks play key roles in immunity and tolerance at body surfaces. LCs are established prenatally and can be replenished from…”
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Multiple Gene Expression Classifiers from Different Array Platforms Predict Poor Prognosis of Colorectal Cancer by LIN, Yu-Hsin, FRIEDERICHS, Jan, MERRIE, Arend E, VAN RIJ, Andre, YOON, Han-Seung, MCCALL, John L, SIEWERT, Jörg Rudiger, HOLZMANN, Bernhard, REEVE, Anthony E, BLACK, Michael A, MAGES, Jörg, ROSENBERG, Robert, GUILFORD, Parry J, PHILLIPS, Vicky, THOMPSON -FAWCETT, Mark, KASABOV, Nikola, TORO, Tumi

“…Purpose: This study aimed to develop gene classifiers to predict colorectal cancer recurrence. We investigated whether gene classifiers derived from two tumor…”
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The phosphoproteome of toll-like receptor-activated macrophages by Lang, Roland, Weintz, Gabriele, Olsen, Jesper V, Frühauf, Katja, Niedzielska, Magdalena, Amit, Ido, Jantsch, Jonathan, Mages, Jörg, Frech, Cornelie, Dölken, Lars, Mann, Matthias

“…Recognition of microbial danger signals by toll‐like receptors (TLR) causes re‐programming of macrophages. To investigate kinase cascades triggered by the TLR4…”
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Extracellular and Intracellular Pattern Recognition Receptors Cooperate in the Recognition of Helicobacter pylori by Rad, Roland, Ballhorn, Wibke, Voland, Petra, Eisenächer, Katharina, Mages, Jörg, Rad, Lena, Ferstl, Ruth, Lang, Roland, Wagner, Hermann, Schmid, Roland M, Bauer, Stefan, Prinz, Christian, Kirschning, Carsten J, Krug, Anne

“…Background & Aims Helicobacter pylori infects half of the world's population, thereby causing significant human morbidity and mortality. The mechanisms by…”
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Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling by Farhat, Katja, Riekenberg, Sabine, Heine, Holger, Debarry, Jennifer, Lang, Roland, Mages, Jörg, Buwitt‐Beckmann, Ute, Röschmann, Kristina, Jung, Günther, Wiesmüller, Karl‐Heinz, Ulmer, Artur J.

“…TLR are primary triggers of the innate immune system by recognizing various microorganisms through conserved pathogen‐associated molecular patterns. TLR2 is…”
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Pronounced Phenotype in Activated Regulatory T Cells during a Chronic Helminth Infection by Layland, Laura E, Mages, Jorg, Loddenkemper, Christoph, Hoerauf, Achim, Wagner, Hermann, Lang, Roland, Prazeres da Costa, Clarissa U

“…Although several markers have been associated with the characterization of regulatory T cells (Tregs) and their function, no studies have investigated the…”
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Opposing functions of IKKβ during acute and chronic intestinal inflammation by Eckmann, Lars, Nebelsiek, Tim, Fingerle, Alexander A, Dann, Sara M, Mages, Jörg, Lang, Roland, Robine, Sylvie, Kagnoff, Martin F, Schmid, Roland M, Karin, Michael, Arkan, Melek C, Greten, Florian R

“…NF-κB is a key transcriptional regulator of inflammatory responses, but also controls expression of prosurvival genes, whose products protect tissues from…”
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Highly sensitive detection of early‐stage pancreatic cancer by multimodal near‐infrared molecular imaging in living mice by von Burstin, Johannes, Eser, Stefan, Seidler, Barbara, Meining, Alexander, Bajbouj, Monther, Mages, Jörg, Lang, Roland, Kind, Alexander J., Schnieke, Angelika E., Schmid, Roland M., Schneider, Günter, Saur, Dieter

“…Pancreatic cancer is a serious disease with poor patient outcome, often as a consequence of late diagnosis in advanced stages. This is in large part due to the…”
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Differential gene expression patterns of EBV infected EBNA-3A positive and negative human B lymphocytes by Hertle, Marie L, Popp, Claudia, Petermann, Sabine, Maier, Sabine, Kremmer, Elisabeth, Lang, Roland, Mages, Jörg, Kempkes, Bettina

“…The genome of Epstein-Barr virus (EBV) encodes 86 proteins, but only a limited set is expressed in EBV-growth transformed B cells, termed lymphoblastoid cell…”
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