Search Results - "Mager, Dixie L."

Ten things you should know about transposable elements by Bourque, Guillaume, Burns, Kathleen H, Gehring, Mary, Gorbunova, Vera, Seluanov, Andrei, Hammell, Molly, Imbeault, Michaël, Izsvák, Zsuzsanna, Levin, Henry L, Macfarlan, Todd S, Mager, Dixie L, Feschotte, Cédric

“…Transposable elements (TEs) are major components of eukaryotic genomes. However, the extent of their impact on genome evolution, function, and disease remain a…”
Get full text

Endogenous retroviral promoter exaptation in human cancer by Babaian, Artem, Mager, Dixie L

“…Cancer arises from a series of genetic and epigenetic changes, which result in abnormal expression or mutational activation of oncogenes, as well as…”
Get full text

Transposable Elements: An Abundant and Natural Source of Regulatory Sequences for Host Genes by Rebollo, Rita, Romanish, Mark T, Mager, Dixie L

“…The fact that transposable elements (TEs) can influence host gene expression was first recognized more than 50 years ago. However, since that time, TEs have…”
Get full text

Transposable elements in the mammalian embryo: pioneers surviving through stealth and service by Gerdes, Patricia, Richardson, Sandra R, Mager, Dixie L, Faulkner, Geoffrey J

“…Transposable elements (TEs) are notable drivers of genetic innovation. Over evolutionary time, TE insertions can supply new promoter, enhancer, and insulator…”
Get full text

DNA Methylation and SETDB1/H3K9me3 Regulate Predominantly Distinct Sets of Genes, Retroelements, and Chimeric Transcripts in mESCs by Karimi, Mohammad M., Goyal, Preeti, Maksakova, Irina A., Bilenky, Misha, Leung, Danny, Tang, Jie Xin, Shinkai, Yoichi, Mager, Dixie L., Jones, Steven, Hirst, Martin, Lorincz, Matthew C.

“…DNA methylation and histone H3 lysine 9 trimethylation (H3K9me3) play important roles in silencing of genes and retroelements. However, a comprehensive…”
Get full text

Mammalian Endogenous Retroviruses by Mager, Dixie L, Stoye, Jonathan P

“…Over 40% of mammalian genomes comprise the products of reverse transcription. Among such retrotransposed sequences are those characterized by the presence of…”
Get more information

Mouse germ line mutations due to retrotransposon insertions by Gagnier, Liane, Belancio, Victoria P, Mager, Dixie L

“…Transposable element (TE) insertions are responsible for a significant fraction of spontaneous germ line mutations reported in inbred mouse strains. This major…”
Get full text

Loss of m1acp3Ψ Ribosomal RNA Modification Is a Major Feature of Cancer by Babaian, Artem, Rothe, Katharina, Girodat, Dylan, Minia, Igor, Djondovic, Sara, Milek, Miha, Spencer Miko, Sandra E., Wieden, Hans-Joachim, Landthaler, Markus, Morin, Gregg B., Mager, Dixie L.

“…The ribosome is an RNA-protein complex that is essential for translation in all domains of life. The structural and catalytic core of the ribosome is its…”
Get full text

Integrin-Linked Kinase Mediates Therapeutic Resistance of Quiescent CML Stem Cells to Tyrosine Kinase Inhibitors by Rothe, Katharina, Babaian, Artem, Nakamichi, Naoto, Chen, Min, Chafe, Shawn C., Watanabe, Akie, Forrest, Donna L., Mager, Dixie L., Eaves, Connie J., Dedhar, Shoukat, Jiang, Xiaoyan

“…Patients with chronic myeloid leukemia (CML) often require lifelong therapy with ABL1 tyrosine kinase inhibitors (TKIs) due to a persisting TKI-resistant…”
Get full text

LIONS: analysis suite for detecting and quantifying transposable element initiated transcription from RNA-seq by Babaian, Artem, Thompson, I Richard, Lever, Jake, Gagnier, Liane, Karimi, Mohammad M, Mager, Dixie L

“…Abstract Summary Transposable elements (TEs) influence the evolution of novel transcriptional networks yet the specific and meaningful interpretation of how…”
Get full text

Pluripotency and the endogenous retrovirus HERVH: Conflict or serendipity? by Izsvák, Zsuzsanna, Wang, Jichang, Singh, Manvendra, Mager, Dixie L, Hurst, Laurence D

“…Remnants of ancient retroviral infections during evolution litter all mammalian genomes. In modern humans, such endogenous retroviral (ERV) sequences comprise…”
Get full text

Retrotransposon-induced heterochromatin spreading in the mouse revealed by insertional polymorphisms by Rebollo, Rita, Karimi, Mohammad M, Bilenky, Misha, Gagnier, Liane, Miceli-Royer, Katharine, Zhang, Ying, Goyal, Preeti, Keane, Thomas M, Jones, Steven, Hirst, Martin, Lorincz, Matthew C, Mager, Dixie L

“…The "arms race" relationship between transposable elements (TEs) and their host has promoted a series of epigenetic silencing mechanisms directed against TEs…”
Get full text

Reality check for transposon enhancers by Brind'Amour, Julie, Mager, Dixie L

“…Hundreds of retrovirus-like sequences have features that suggest they might be gene enhancers, but only a small fraction displays gene-regulating activity in…”
Get full text

Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency by Ellis, James, Hotta, Akitsu, Cheung, Aaron Y L, Farra, Natalie, Vijayaragavan, Kausalia, Séguin, Cheryle A, Draper, Jonathan S, Pasceri, Peter, Maksakova, Irina A, Mager, Dixie L, Rossant, Janet, Bhatia, Mickie

“…Lentiviral vectors that express a fluorescent reporter and a selectable marker in pluripotent cells improve and simplify isolation of induced pluripotent stem…”
Get full text

Human Th1 and Th17 cells exhibit epigenetic stability at signature cytokine and transcription factor loci by Cohen, Carla J, Crome, Sarah Q, MacDonald, Kate G, Dai, Elizabeth L, Mager, Dixie L, Levings, Megan K

“…The linear model of Th cell lineage commitment is being revised due to reports that mature Th cells can trans-differentiate into alternate lineages. This…”
Get full text

Role of Runt-related Transcription Factor 3 (RUNX3) in Transcription Regulation of Natural Cytotoxicity Receptor 1 (NCR1/NKp46), an Activating Natural Killer (NK) Cell Receptor by Lai, C. Benjamin, Mager, Dixie L.

“…Natural cytotoxicity receptor 1 (NCR1), also known as NKp46, is a natural killer (NK) lymphocyte-activating receptor. It is involved in major aspects of NK…”
Get full text

Distributions of transposable elements reveal hazardous zones in mammalian introns by Zhang, Ying, Romanish, Mark T, Mager, Dixie L

“…Comprising nearly half of the human and mouse genomes, transposable elements (TEs) are found within most genes. Although the vast majority of TEs in introns…”
Get full text

Distinct isoform of FABP7 revealed by screening for retroelement-activated genes in diffuse large B-cell lymphoma by Lock, Frances E, Rebollo, Rita, Miceli-Royer, Katharine, Gagnier, Liane, Kuah, Sabrina, Babaian, Artem, Sistiaga-Poveda, Maialen, Lai, C Benjamin, Nemirovsky, Oksana, Serrano, Isabel, Steidl, Christian, Karimi, Mohammad M, Mager, Dixie L

“…Remnants of ancient transposable elements (TEs) are abundant in mammalian genomes. These sequences harbor multiple regulatory motifs and hence are capable of…”
Get full text

Lysine methyltransferase G9a is required for de novo DNA methylation and the establishment, but not the maintenance, of proviral silencing by Leung, Danny C, Dong, Kevin B, Maksakova, Irina A, Goyal, Preeti, Appanah, Ruth, Lee, Sandra, Tachibana, Makoto, Shinkai, Yoichi, Lehnertz, Bernhard, Mager, Dixie L, Rossi, Fabio, Lorincz, Matthew C

“…Methylation on lysine 9 of histone H3 (H3K9me) and DNA methylation play important roles in the transcriptional silencing of specific genes and repetitive…”
Get full text

A novel isoform of IL-33 revealed by screening for transposable element promoted genes in human colorectal cancer by Lock, Frances E, Babaian, Artem, Zhang, Ying, Gagnier, Liane, Kuah, Sabrina, Weberling, Antonia, Karimi, Mohammad M, Mager, Dixie L

“…Remnants of ancient transposable elements (TEs) are abundant in mammalian genomes. These sequences contain multiple regulatory motifs and hence are capable of…”
Get full text