Timing for maximum anaesthetic effect of topical cream during early infant circumcision (EIC) in Rakai, Uganda

Objectives The objective of this study is to determine the optimal timing for device‐based infant circumcision under topical anaesthesia. Subjects/patients We include infants aged 1–60 days who were enrolled in a field study of the no‐flip ShangRing device at four hospitals in the Rakai region of so...

Full description

Saved in:

Bibliographic Details
Published in:	BJUI compass Vol. 4; no. 4; pp. 423 - 429
Main Authors:	Kiboneka, Stephen, Anok, Aggrey, Nakabuye, Regina, Odiya, Silas, Magembe, Julius, Nazziwa, Rose, Ddamulira, Charles, Mulooki, Andrew, Galiwango, Ronald Moses, Watya, Stephen, Li, Philip S., Lee, Richard K., Gray, Ronald H., Kigozi, Godfrey, Kankaka, Edward Nelson
Format:	Journal Article
Language:	English
Published:	United States John Wiley & Sons, Inc 01-07-2023 John Wiley and Sons Inc Wiley
Subjects:	Acquired immune deficiency syndrome AIDS Analgesics Anesthesia Babies Circumcision Confidence intervals EIC EIMC Field study Gestational age Health sciences HIV Human immunodeficiency virus infant circumcision Legs Medical referrals Newborn babies Original Pain pain measurement timing topical anaesthesia Uganda infant circumcision pain measurement EIMC topical anaesthesia timing EIC
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Objectives The objective of this study is to determine the optimal timing for device‐based infant circumcision under topical anaesthesia. Subjects/patients We include infants aged 1–60 days who were enrolled in a field study of the no‐flip ShangRing device at four hospitals in the Rakai region of south‐central Uganda, between 5 February 2020 and 27 October 2020. Methods Two hundred infants, aged 0–60 days, were enrolled, and EMLA cream was applied on the foreskin and entire penile shaft. The anaesthetic effect was assessed every 5 min by gentle application of artery forceps at the tip of the foreskin, starting at 10 min post‐application until 60 min, the recommended time to start circumcision. The response was measured using the Neonatal Infant Pain Scale (NIPS). We determined the onset and duration of anaesthesia (defined as <20% of infants with NIPS score >4) and maximum anaesthesia (defined as <20% of infants with NIPS score >2). Results Overall, NIPS scores decreased to a minimum and reversed before the recommended 60 min. Baseline response varied with age, with minimal response among infants aged 40 days. Overall, anaesthesia was achieved after at least 25 min and lasted 20–30 min. Maximum anaesthesia was achieved after at least 30 min (except among those aged >45 days where it was not achieved) and lasted up to 10 min. Conclusion The optimal timing for maximum topical anaesthesia occurred before the recommended 60 min of waiting time. A shorter waiting time and speed may be efficient for mass device‐based circumcision.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2688-4526 2688-4526
DOI:	10.1002/bco2.223