Search Results - "Magee, D E"

Adverse event profile for immunotherapy agents compared with chemotherapy in solid organ tumors: a systematic review and meta-analysis of randomized clinical trials by Magee, D.E., Hird, A.E., Klaassen, Z., Sridhar, S.S., Nam, R.K., Wallis, C.J.D., Kulkarni, G.S.

“…Immunotherapy agents are an innovative oncological treatment modality and as a result their use has expanded widely. Understanding the treatment-related…”
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Time-dependent changes in biochemical bone markers and serum cholesterol in ovariectomized rats: Effects of raloxifene HCl, tamoxifen, estrogen, and alendronate by Frolik, C.A., Bryant, H.U., Black, E.C., Magee, D.E., Chandrasekhar, S.

“…Bone loss associated with postmenopausal osteoporosis can be reduced by treatment with antiresorptive agents such as estrogen or bisphosphonates. Whereas…”
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Raloxifene (LY139481 HCl) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats by BLACK, L. J, SATO, M, FROLIK, C. A, TERMINE, J. D, BRYANT, H. U, ROWLEY, E. R, MAGEE, D. E, BEKELE, A, WILLIAMS, D. C, CULLINAN, G. J, BENDELE, R, KAUFFMAN, R. F, BENSCH, W. R

“…There is a medical need for an agent with the positive effects of estrogen on bone and the cardiovascular system, but without the negative effects on…”
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Synthesis and Pharmacology of Conformationally Restricted Raloxifene Analogues:  Highly Potent Selective Estrogen Receptor Modulators by Grese, Timothy A., Pennington, Lewis D., Sluka, James P., Adrian, M. Dee, Cole, Harlan W., Fuson, Tina R., Magee, David E., Phillips, D. Lynn, Rowley, Ellen R., Shetler, Pamela K., Short, Lorri L., Venugopalan, Murali, Yang, Na N., Sato, Masahiko, Glasebrook, Andrew L., Bryant, Henry U.

“…The 2-arylbenzothiophene raloxifene, 1, is a selective estrogen receptor modulator (SERM) which is currently under clinical evaluation for the prevention and…”
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Structure−Activity Relationships of Selective Estrogen Receptor Modulators:  Modifications to the 2-Arylbenzothiophene Core of Raloxifene by Grese, Timothy A, Cho, Stephen, Finley, Don R, Godfrey, Alexander G, Jones, Charles D, Lugar, Charles W, Martin, Michael J, Matsumoto, Ken, Pennington, Lewis D, Winter, Mark A, Adrian, M. Dee, Cole, Harlan W, Magee, David E, Phillips, D. Lynn, Rowley, Ellen R, Short, Lorri L, Glasebrook, Andrew L, Bryant, Henry U

“…The 2-arylbenzothiophene raloxifene, 1, is a selective estrogen receptor modulator which is currently under clinical evaluation for the prevention and…”
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Environmental estrogens: Effects on cholesterol lowering and bone in the ovariectomized rat by Dodge, Jeffrey A., Glasebrook, Andrew L., Magee, David E., Phillips, David L., Sato, Masahiko, Short, Lorri L., Bryant, Henry U.

“…Representative non-steroidal estrogens, from common environmental sources such as plants, pesticides, surfactants, plastics, and animal health products,…”
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Clomiphene Prevents Cancellous Bone Loss from Tibia of Ovariectomized Rats by Jimenez, M. A, Magee, D. E, Bryant, H. U, Turner, R. T

“…Estrogen inhibits postmenopausal bone loss and decreases fracture risk. Unfortunately, estrogen replacement therapy has many undesirable side effects, the…”
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Raloxifene is a tissue-selective agonist/antagonist that functions through the estrogen receptor by Fuchs-Young, R, Glasebrook, A L, Short, L L, Draper, M W, Rippy, M K, Cole, H W, Magee, D E, Termine, J D, Bryant, H U

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Effect of weight manipulation on bone loss due to ovariectomy and the protective effects of estrogen in the rat by ROUDEBUSH, R. E, MAGEE, D. E, BENSLAY, D. N, BENDELE, A. M, BRYANT, H. U

“…While characterizing the effects of estrogen on an ovariectomized (OVX) rat model of bone loss, we examined several weight-matching regimens [e.g., ad libitum…”
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Characterization of a thromboxane A2/prostaglandin H2 receptor in guinea pig lung membranes using a radioiodinated thromboxane mimetic by Saussy, Jr, D L, Mais, D E, Dubé, G P, Magee, D E, Brune, K A, Kurtz, W L, Williams, C M

“…Thromboxane A2 (TXA2) and prostaglandin H2 (PGH2) are potent constrictors of airway smooth muscle and may mediate some of the pulmonary effects of…”
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Raloxifene inhibits bone turnover and prevents further cancellous bone loss in adult ovariectomized rats with established osteopenia by Evans, G L, Bryant, H U, Magee, D E, Turner, R T

“…Estrogen (E) treatment has proven to be effective in preventing bone loss after menopause with, however, some undesirable side effects. Many of these side…”
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Clomiphene prevents cancellous bone loss from tibia of ovariectomized rats by Jimenez, M A, Magee, D E, Bryant, H U, Turner, R T

“…Estrogen inhibits postmenopausal bone loss and decreases fracture risk. Unfortunately, estrogen replacement therapy has many undesirable side effects, the…”
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Serotonin-induced paw edema in the rat: Pharmacological profile by Cole, Harlan W., Brown, Charles E., Magee, David E., Magee, Christopher, Roudebush, Roger E., Bryant, Henry U.

“…1. 1. Serotonin (5-HT) induced a linear increase in paw weight in rats within 1hr of an intraplantar injection (50μ1 vol) over a concentration range of…”
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Binding of a radioiodinated agonist to thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptors in guinea pig lung membranes by Mais, D E, Saussy, Jr, D L, Magee, D E, Williams, C M

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Effects of prolonged ethinyl estradiol treatment on calcium channel binding and in vivo calcium-mediated hemodynamic responses in ovariectomized rats by Bowling, N, Bloomquist, W E, Cohen, M L, Bryant, H U, Cole, H W, Magee, D E, Rowley, E R, Vlahos, C J

“…Ethinyl estradiol (EE2), administered orally to ovariectomized (ovex) rats, has been shown to prevent loss of bone mineral density and to decrease serum…”
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Raloxifene inhibits bone turnover and prevents further cancellous bone loss in adult ovariectomized rats with established osteopenia by Evans, G L, Bryant, H U, Magee, D E, Turner, R T

“…Estrogen (E) treatment has proven to be effective in preventing bone loss after menopause with, however, some undesirable side effects. Many of these side…”
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Interaction of 5-HETE, 12-HETE, 15-HETE and 5,12-diHETE at the human platelet thromboxane A2/prostaglandin H2 receptor by Mais, D E, Saussy, Jr, D L, Magee, D E, Bowling, N L

“…A variety of lipoxygenase products such as 12- and 15-hydroxyeicosatetraenoic acid (12- and 15-HETE) inhibit thromboxane A2 (TXA2) mimetic induced human…”
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Squeezes in Grantham Museum Made by Alice Lieder in 1851-2 by Magee, D. N. E., Malek, J.

“…Brief description of a collection of squeezes made at a dozen different sites in Egypt and Nubia. These are among the earliest preserved in the United Kingdom…”
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Rapid tumor development with a modified MCF-7 xenograft model by Hale, L V, Layman, N K, Wilson, P, Short, L L, Magee, D E, Wightman, S R, Fuchs-Young, R

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Benzopyran selective estrogen receptor modulators (SERMs): Pharmacological effects and structural correlation with raloxifene by Grese, Timothy A., Sluka, James P., Bryant, Henry U., Cole, Harlan W., Kim, John R., Magee, David E., Rowley, Ellen R., Sato, Masahiko

“…Several 2,3-diarylbenzopyrans have been evaluated in an ovariectomized rat model and found to exhibit tissue selective estrogen agonist activity on bone and…”
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