Search Results - "Magazanik, L. G"

Determinants of trapping block of N‐methyl‐d‐aspartate receptor channels by Bolshakov, K. V., Gmiro, V. E., Tikhonov, D. B., Magazanik, L. G.

“…Open channel blockers of NMDA receptors interact with the channel gate in different ways. Compounds like MK‐801 and phencyclidine exhibit pronounced trapping…”
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Block of open channels of recombinant AMPA receptors and native AMPA/kainate receptors by adamantane derivatives by Magazanik, L. G., Buldakova, S. L., Samoilova, M. V., Gmiro, V. E., Mellor, I. R., Usherwood, P. N. R.

“…1. The effects of two adamantane derivatives, 1-trimethylammonio-5-(1-adamantane-methyl-ammoniopentane dibromide) (IEM-1460) and…”
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IEM-1925, a Glutamate Receptor Channel Blocker, Increases the Latent Period and Decreases the Duration of Status Epilepticus in Rats in a Lithium-Pilocarpine Model of Epilepsy by Vataev, S. I., Lukomskaya, N. Ya, Magazanik, L. G.

“…Chronic experiments on male Wistar and Krushinskii–Molodkina rats, the latter having an inherited predisposition for audiogenic convulsions, addressed the…”
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Status epilepticus impairs synaptic plasticity in rat hippocampus and is followed by changes in expression of NMDA receptors by Postnikova, T. Y., Zubareva, O. E., Kovalenko, A. A., Kim, K. K., Magazanik, L. G., Zaitsev, A. V.

“…Cognitive deficits and memory loss are frequent in patients with temporal lobe epilepsy. Persistent changes in synaptic efficacy are considered as a cellular…”
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Design of antagonists for NMDA and AMPA receptors by Bolshakov, K.V., Kim, K.H., Potapjeva, N.N., Gmiro, V.E., Tikhonov, D.B., Usherwood, P.N.R., Mellor, I.R., Magazanik, L.G.

“…Determinants of antagonism of NMDA and calcium permeable AMPA receptor channels by organic cations were studied using several homologous series of mono- and…”
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Ligands of Acid-Sensing Ion Channel 1a: Mechanisms of Action and Binding Sites by Tikhonov, D B, Magazanik, L G, Nagaeva, E I

“…The proton-gated cationic channels belonging to the ASIC family are widely distributed in the central nervous system of vertebrates and play an important role…”
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Action of extracellular divalent cations on native α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate (AMPA) receptors by Dorofeeva, N. A., Tikhonov, D. B., Barygin, O. I., Tikhonova, T. B., Salnikov, Y. I., Magazanik, L. G.

“…The effects of divalent cations on Ca2+‐impermeable containing (GluR2 subunit) MPA receptors of hippocampal pyramidal neurones isolated from rat brain was…”
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Different arrangement of hydrophobic and nucleophilic components of channel binding sites in N-methyl- d-aspartate and AMPA receptors of rat brain is revealed by channel blockade by Bolshakov, K.V, Tikhonov, D.B, Gmiro, V.E, Magazanik, L.G

“…In order to investigate the topography of the channel binding site in (±)-α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) and N-methyl- d-aspartate…”
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The NMDA Receptor Channel Blockers Memantine and IEM-1921 Decrease the Duration of Status Epilepticus in Wistar and Krushinskii–Molodkina Rats in a Lithium-Pilocarpine Model by Vataev, S. I., Zaitsev, A. V., Lukomskaya, N. Ya, Magazanik, L. G.

“…Chronic experiments on Wistar and Krushinskii–Molodkina rats, which have an inherited predisposition to audiogenic convulsions, addressed the effects of…”
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Synaptic Dysfunction in Epilepsy by Zaitsev, А. V., Amakhin, D. V., Dyomina, A. V., Zakharova, M. V., Ergina, J. L., Postnikova, T. Y., Diespirov, G. P., Magazanik, L. G.

“…Epilepsy is one of the prevalent cerebral diseases, and despite intensive research of this pathology for many years, modern medicine cannot effectively control…”
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The open channel blocking drug, IEM-1460, reveals functionally distinct α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors in rat brain neurons by Samoilova, M.V, Buldakova, S.L, Vorobjev, V.S, Sharonova, I.N, Magazanik, L.G

“…The properties of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors were examined in various cell types isolated from young rat hippocampus,…”
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Neuroinfl ammatory Processes Affect Structural Changes in the Amygdala of Rats in a Lithium-Pilocarpine Model of Epilepsy by Vasilev, D. S., Tumanova, N. L., Kovalenko, A. A., Zubareva, O. E., Kalemenev, S. V., Magazanik, L. G.

“…Temporal epilepsy is a severe neuromental disorder which is difficult to treat and whose pathogenesis is presumptively linked with the development of…”
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Modulatory role of adenosine receptors in insect motor nerve terminals by Magazanik, L G, Fedorova, I M

“…The effects of adenosine and ATP were studied on blowfly larvae Calliphora vicina neuromuscular preparation. Adenosine diminished (IC50 = 40 +/- 3 microM) the…”
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Bioelectrical Activity in the Sleep–Waking Cycle in Rats after Pilocarpine-Induced Status Epilepticus by Vataev, S. I., Zaitsev, A. V., Lukomskaya, N. Ya, Magazanik, L. G.

“…Chronic recording of electrograms of the somatosensory, auditory, and visual cortex, the hippocampus, and the caudate nucleus in Krushinskii–Molodkina and…”
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Statistical models suggest presence of two distinct subpopulations of miniature EPSCs in fast-spiking interneurons of rat prefrontal cortex by Malkin, S.L, Kim, K.K, Tikhonov, D.B, Magazanik, L.G, Zaitsev, A.V

“…Graphical abstract…”
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Status epilepticus induced by pentylenetetrazole increases short-term synaptic facilitation in the hippocampus of juvenile rats by Postnikova, T. Yu, Trofimova, A. M., Zaitsev, A. V., Magazanik, L. G.

“…We studied the effect of status epilepticus (SE) on short-term synaptic plasticity. The amplitudes of field potentials in response to extracellular stimulation…”
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Specific mechanism of use‐dependent channel block of calcium‐permeable AMPA receptors provides activity‐dependent inhibition of glutamatergic neurotransmission by Zaitsev, A. V., Kim, K. K., Fedorova, I. M., Dorofeeva, N. A., Magazanik, L. G., Tikhonov, D. B.

“…Non‐technical summary  Calcium‐permeable (CP) AMPA receptors play an important role in many synaptic functions and neuronal death. In this study, we…”
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AMPAR-mediated Interictal Discharges in Neurons of Entorhinal Cortex: Experiment and Model by Chizhov, A. V., Amakhin, D. V., Zaizev, A. V., Magazanik, L. G.

“…The mechanisms of interictal discharges (IID) were studied under the conditions of the 4-aminopyridine model of spontaneous epileptiform activity in surviving…”
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Characterization of acid-sensitive ion channels in freshly isolated rat brain neurons by Bolshakov, K.V, Essin, K.V, Buldakova, S.L, Dorofeeva, N.A, Skatchkov, S.N, Eaton, M.J, Tikhonov, D.B, Magazanik, L.G

“…Transient proton-activated currents induced by rapid shifts of the extracellular pH from 7.4 to ≤6.8 were recorded in different neurons freshly isolated from…”
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Ion channels of glutamate receptors of nerve-muscle junction of larva of the fly Calliphora vicina demonstrate a high structural homology with vertebrate AMPA-channels by Fedorova, I. M, Gmiro, V. E, Magazanik, L. G, Tikhonov, D. B

“…In experiments on the nerve-muscle junction of larvae of the fly Calliphora vicina, regularities of the blocking action of organic cations on ion channels of…”
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