Search Results - "Magalhaes, Joao G"

Unleashing the therapeutic potential of NOD-like receptors by Girardin, Stephen E, Geddes, Kaoru, Magalhães, João G

“…Key Points Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are a newly described family of intracellular sensors of microbial…”
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NOD1 Activators Link Innate Immunity to Insulin Resistance by SCHERTZER, Jonathan D, TAMRAKAR, Akhilesh K, KLIP, Amira, MAGALHAES, Joao G, PEREIRA, Sandra, BILAN, Philip J, FULLERTON, Morgan D, ZHI LIU, STEINBERG, Gregory R, GIACCA, Adria, PHILPOTT, Dana J

“…Insulin resistance associates with chronic inflammation, and participatory elements of the immune system are emerging. We hypothesized that bacterial elements…”
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Presentation of Phagocytosed Antigens by MHC Class I and II by Mantegazza, Adriana R., Magalhaes, Joao G., Amigorena, Sebastian, Marks, Michael S.

“…Phagocytosis provides innate immune cells with a mechanism to take up and destroy pathogenic bacteria, apoptotic cells and other large particles. In some…”
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Critical role for Sec22b-dependent antigen cross-presentation in antitumor immunity by Alloatti, Andrés, Rookhuizen, Derek C, Joannas, Leonel, Carpier, Jean-Marie, Iborra, Salvador, Magalhaes, Joao G, Yatim, Nader, Kozik, Patrycja, Sancho, David, Albert, Matthew L, Amigorena, Sebastian

“…CD8 T cells mediate antigen-specific immune responses that can induce rejection of solid tumors. In this process, dendritic cells (DCs) are thought to take up…”
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NLRC5 limits the activation of inflammatory pathways by Benko, Szilvia, Magalhaes, Joao G, Philpott, Dana J, Girardin, Stephen E

“…Nod-like receptors (NLRs) are intracellular sentinel proteins that are implicated in the detection of microbes and danger signals, thereby controlling several…”
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Essential role of Rip2 in the modulation of innate and adaptive immunity triggered by Nod1 and Nod2 ligands by Magalhaes, Joao G., Lee, Jooeun, Geddes, Kaoru, Rubino, Stephen, Philpott, Dana J., Girardin, Stephen E.

“…Muramyl peptides are the building blocks of bacterial peptidoglycan, and their biological functions in mammals have been extensively studied. In particular,…”
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IFT20 controls LAT recruitment to the immune synapse and T-cell activation in vivo by Vivar, Omar I., Masi, Giulia, Carpier, Jean-Marie, Magalhaes, Joao G., Galgano, Donatella, Pazour, Gregory J., Amigorena, Sebastian, Hivroz, Claire, Baldari, Cosima T.

“…Biogenesis of the immune synapse at the interface between antigen-presenting cells and T cells assembles and organizes a large number of membrane proteins…”
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Nod1 and Nod2 Regulation of Inflammation in the Salmonella Colitis Model by Geddes, Kaoru, Rubino, Stephen, Streutker, Catherine, Cho, Joon Ho, Magalhaes, Joao G, Le Bourhis, Lionel, Selvanantham, Thirumahal, Girardin, Stephen E, Philpott, Dana J

“…The pattern recognition molecules Nod1 and Nod2 play important roles in intestinal homeostasis; however, how these proteins impact on the development of…”
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The intestinal epithelial barrier: How to distinguish between the microbial flora and pathogens by Magalhaes, Joao G, Tattoli, Ivan, Girardin, Stephen E

“…Abstract The gastrointestinal tract is fundamental for the uptake of nutrients and fluids, but it also represents the greatest surface of the body in contact…”
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Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation by Magalhaes, Joao G, Rubino, Stephen J, Travassos, Leonardo H, Le Bourhis, Lionel, Duan, Wei, Sellge, Gernot, Geddes, Karou, Reardon, Colin, Lechmann, Matthias, Carneiro, Leticia A, Selvanantham, Thirumahal, Fritz, Jorg H, Taylor, Betsy C, Artis, David, Mak, Tak Wah, Comeau, Michael R, Croft, Michael, Girardin, Stephen E, Philpott, Dana J

“…Although a number of studies have examined the development of T-helper cell type 2 (Th2) immunity in different settings, the mechanisms underlying the…”
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Nod1 and Nod2 induce CCL5/RANTES through the NF-κB pathway by Werts, Catherine, le Bourhis, Lionel, Liu, Jianguo, Magalhaes, Joao G, Carneiro, Leticia A, Fritz, Jörg H, Stockinger, Silvia, Balloy, Viviane, Chignard, Michel, Decker, Thomas, Philpott, Dana J, Ma, Xiaojing, Girardin, Stephen E

“…The Nod-like receptor proteins Nod1 and Nod2 participate in innate immune responses against bacteria through intracellular detection of peptidoglycan, a…”
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The Nodosome: Nod1 and Nod2 control bacterial infections and inflammation by Tattoli, Ivan, Travassos, Leonardo H, Carneiro, Leticia A, Magalhaes, Joao G, Girardin, Stephen E

“…Toll-like receptors (TLRs) and the nucleotide-binding domain, leucine rich repeat containing family (or Nod-like receptors, NLRs) are two important families of…”
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Sumoylation coordinates the repression of inflammatory and anti-viral gene-expression programs during innate sensing by Decque, Adrien, Joffre, Olivier, Magalhaes, Joao G, Cossec, Jack-Christophe, Blecher-Gonen, Ronnie, Lapaquette, Pierre, Silvin, Aymeric, Manel, Nicolas, Joubert, Pierre-Emmanuel, Seeler, Jacob-Sebastian, Albert, Matthew L, Amit, Ido, Amigorena, Sebastian, Dejean, Anne

“…Sumolyation regulates wide-ranging biological processes, but its influence on innate immunity is unclear. Amigorena and colleagues show that sumoylation…”
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Identification of an innate T helper type 17 response to intestinal bacterial pathogens by Geddes, Kaoru, Rubino, Stephen J, Magalhaes, Joao G, Streutker, Catherine, Le Bourhis, Lionel, Cho, Joon Ho, Robertson, Susan J, Kim, Connie J, Kaul, Rupert, Philpott, Dana J, Girardin, Stephen E

“…T helper type 17 (T H 17) responses are crucial for immunity to intestinal pathogens. Here, Stephen E. Girardin, Dana J. Philpott and their colleagues report…”
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NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-κB and JNK pathways by inducing reactive oxygen species production by Tattoli, Ivan, Carneiro, Leticia A, Jéhanno, Muguette, Magalhaes, Joao G, Shu, Youmin, Philpott, Dana J, Arnoult, Damien, Girardin, Stephen E

“…NOD‐like receptors (NLRs) are a family of intracellular sensors of microbial‐ or danger‐associated molecular patterns. Here, we report the identification of…”
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Innate signals from Nod2 block respiratory tolerance and program TH2-driven allergic inflammation by Duan, Wei, Mehta, Amit K., Magalhaes, Joao G., Ziegler, Steven F., Dong, Chen, Philpott, Dana J., Croft, Michael

“…Airway tolerance is critical for protecting the lung from inflammatory disease driven by allergens. However, factors that disrupt tolerance processes and then…”
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What is new with Nods? by Magalhaes, Joao G, Sorbara, Matthew T, Girardin, Stephen E, Philpott, Dana J

“…Over the last few years, much research has focused on determining the function of members of the cytosolic Nod-like receptor (NLR) family in terms of their…”
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Innate signals from Nod2 block respiratory tolerance and program T(H)2-driven allergic inflammation by Duan, Wei, Mehta, Amit K, Magalhaes, Joao G, Ziegler, Steven F, Dong, Chen, Philpott, Dana J, Croft, Michael

“…Airway tolerance is critical for protecting the lung from inflammatory disease driven by allergens. However, factors that disrupt tolerance processes and then…”
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Measurement of Export to the Cytosol in Dendritic Cells Using a Cytofluorimetry-Based Assay by Vivar, Omar I, Magalhaes, Joao G, Amigorena, Sebastian

“…The presentation of exogenous antigens on MHC class I molecules, known as cross-presentation, is a key function of dendritic cells (DCs). Cross-presentation…”
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Shigella induces mitochondrial dysfunction and cell death in nonmyleoid cells by Carneiro, Leticia A M, Travassos, Leonardo H, Soares, Fraser, Tattoli, Ivan, Magalhaes, Joao G, Bozza, Marcelo T, Plotkowski, Maria C, Sansonetti, Philippe J, Molkentin, Jeffery D, Philpott, Dana J, Girardin, Stephen E

“…Shigella rapidly kills myeloid cells via a caspase-1 inflammasome-dependent cell death mechanism. However, despite a critical role for nonmyeloid cells in the…”
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