Effect of Libidibia ferrea bark and seed in maternal reproductive and biochemical outcomes and fetal anomaly in rats

Effect of Libidibia ferrea bark and seed in maternal reproductive and biochemical outcomes and fetal anomaly in rats

Background Unhealthy pregnant women living in underdeveloped regions are usually treated by traditional healers, inadvertent of the potential toxic effects of plant‐derivative substances. Thus, we investigated whether exposure to a hydroalcoholic extract of bark and seed of Libidibia ferrea during p...

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Bibliographic Details
Published in:Birth defects research Vol. 111; no. 13; pp. 863 - 871
Main Authors: Pickler, Thaisa B., Lopes, Karina P., Magalhães, Stefani A., Krueger, Clarissa M. A., Martins, Milene M., Filho, Valdir Cechinel, Jozala, Angela F., Grotto, Denise, Gerenutti, Marli
Format: Journal Article
Language:English
Published: Hoboken, USA John Wiley & Sons, Inc 01-08-2019
Wiley Subscription Services, Inc
Subjects:
Amniotic fluid
Anomalies
Bark
Biochemical composition
Biochemistry
Biocompatibility
Catechin
Creatinine
Exposure
fetal development
Fetuses
High performance liquid chromatography
Iron constituents
Libidibia ferrea
Liquid chromatography
maternal exposure
Offspring
plant extracts
Pregnancy
teratogenesis
Toxicity
maternal exposure
teratogenesis
Libidibia ferrea
plant extracts
fetal development
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Summary:Background Unhealthy pregnant women living in underdeveloped regions are usually treated by traditional healers, inadvertent of the potential toxic effects of plant‐derivative substances. Thus, we investigated whether exposure to a hydroalcoholic extract of bark and seed of Libidibia ferrea during pregnancy results in fetotoxicity and maternal toxicity. The main constituents of both extracts were analyzed by High Performance Liquid Chromatography (HPLC). Methods Pregnant rats were divided into three groups: control (C), group exposed to extract of bark (Lfb—1.0 g/kg/day), and group exposed to extract of the seed (Lfs—1.0 g/kg/day). Biochemical parameters, reproductive capacity, morphological effects in the offspring were analyzed. Results HPLC fingerprint confirmed the presence of ellagic in both bark and seed extracts, and the absence of detectable concentrations of gallic and catechin. Fetuses exposed to L. ferrea extracts presented shorter mean lengths for head and body sections when compared to those in C and exhibited visceral and skeletal anomalies. Pregnant rats exposed to Lfs extracts show alterations in serum creatinine levels and yield amniotic fluid with abnormal biochemical composition. Conclusion Bark or seed extracts of L. ferrea do not exhibit safety level compatible to be used in the gestational period.
ISSN:2472-1727
2472-1727
DOI:10.1002/bdr2.1520