Production of reactive oxygen species induced by a new [60]fullerene derivative bearing a tetrazole unit and its possible biological applications

The wide range of physical and chemical properties of modified fullerenes has drawn increasing attention in the past few years. As part of this research, this paper describes the preparation, characterization, and photophysical properties of a new fullerene derivative chemically modified with a tetr...

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Bibliographic Details
Published in:	Journal of photochemistry and photobiology. A, Chemistry. Vol. 200; no. 2; pp. 277 - 281
Main Authors:	dos Santos, Leandro J., Alves, Rosemeire B., de Freitas, Rossimiriam P., Nierengarten, Jean-François, Magalhães, Lucas E.F., Krambrock, Klaus, Pinheiro, Maurício V.B.
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 15-12-2008
Subjects:	Electron paramagnetic resonance Fullerene C 60 derivative Reactive oxygen species Fullerene C 60 derivative Reactive oxygen species Electron paramagnetic resonance
Online Access:	Get full text
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Summary:	The wide range of physical and chemical properties of modified fullerenes has drawn increasing attention in the past few years. As part of this research, this paper describes the preparation, characterization, and photophysical properties of a new fullerene derivative chemically modified with a tetrazole. The photophysical properties were studied by EPR radical spin-trapping technique and showed that reactive oxygen species (ROS) can be produced through UVA photosensitization. EPR spin-trapping experiments with singlet oxygen ( 1O 2) and superoxide (O 2 −) inhibitors (β-carotene and superoxide dismutase, respectively) revealed also that: (i) the main ROS produced is 1O 2 and (ii) 1O 2 is being partially dismutated to O 2 −. The results suggest that this derivative can be used in biological applications, as for example, in topic photodynamic therapy (PDT) as a photosensitizer.
ISSN:	1010-6030 1873-2666
DOI:	10.1016/j.jphotochem.2008.08.002