Refeeding abolishes beneficial effects of severe calorie restriction from birth on adipose tissue and glucose homeostasis of adult rats

Refeeding abolishes beneficial effects of severe calorie restriction from birth on adipose tissue and glucose homeostasis of adult rats

•long term severe calorie restriction.•refeeding.•adipose tissue.•glucose homeostasis.•Sirtuin. Calorie restriction (CR) is an important intervention for reducing adiposity and improving glucose homeostasis. Recently we found that in rats, a severe calorie restriction (SCR) beginning at birth up to...

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Published in:Nutrition (Burbank, Los Angeles County, Calif.) Vol. 66; pp. 87 - 93
Main Authors: Melo, Dirceu de Sousa, Santos, Carina Sousa, Pereira, Liliane Costa, Mendes, Bruno Ferreira, Jesus, Larissa Santos, Pelaez, Juliana Maria Navia, Aguilar, Edenil Costa, Nascimento, Débora Ribeiro, Martins, Almir de Sousa, Magalhães, Flávio de Catro, Esteves, Elizabethe Adriana, Capettini, Luciano dos Santos Aggum, Dias Peixoto, Marco Fabrício
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01-10-2019
Elsevier Limited
Subjects:
Adipocyte
Adiponectin
Adipose tissue
Age
Antigens
Birth
Body fat
Body weight
Cardiac function
Evere calorie restriction
Food
Food intake
Glucose
Glucose homeostasis
Glucose tolerance
Health risks
Heart
Homeostasis
Immunological tolerance
Insulin
Insulin resistance
Laboratory animals
Metabolism
Mothers
Nutrient deficiency
Proliferating cell nuclear antigen
Refeeding
Risk analysis
Risk factors
Rodents
SIRT1 signaling
Visceral fat
United States > US
Visceral fat
Adipocyte
SIRT1 signaling
Evere calorie restriction
Refeeding
Glucose homeostasis
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Summary:•long term severe calorie restriction.•refeeding.•adipose tissue.•glucose homeostasis.•Sirtuin. Calorie restriction (CR) is an important intervention for reducing adiposity and improving glucose homeostasis. Recently we found that in rats, a severe calorie restriction (SCR) beginning at birth up to adult age promotes positive effects on cardiometabolic risk factors and heart. The aim of this study was to investigate the effects of this new model of SCR on adipose tissue and glucose homeostasis of rats and to evaluate the effects of refeeding. From birth to 90 d of age, rats were divided into an ad libitum (AL) group, which had free access to food, and a CR50 group, which had food limited to 50% of that consumed by the AL group. From this moment, half of the CR50 animals had free access to food (the refeeding group [CR50-R]), and the other half continued 50% restricted for an additional 90-d period. Food intake was assessed daily and body weight weekly. In the final week of the SCR/refeeding protocol, oral glucose and intraperitoneal insulin tolerance tests were performed. Thereafter, rats were sacrificed and visceral fat was collected and used for histologic and Western blot analysis. Findings from this study revealed that SCR beginning at birth and up to adult life promoted a large decrease in visceral adiposity; improvement in glucose/insulin tolerance; and upregulation of adipose proliferating cell nuclear antigen, sirtuin 1, peroxisome proliferator-activated receptor-γ, and adiponectin. Refeeding abolished all of these effects. SCR from birth to adult age promoted beneficial effects on adipose tissue and glucose homeostasis; whereas refeeding abolished these effects.
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ISSN:0899-9007
1873-1244
DOI:10.1016/j.nut.2019.03.022