Proinflammatory and regulatory cytokine levels in AIDS cachexia

The serum concentrations of inflammatory (Interleukin-1 beta, Tumor necrosis alpha, Interleukin-6) and regulatory cytokines (Interleukin twelve) have been studied in ten AIDS cachectic patients and compared to a control group. A cytokine imbalance, and peculiarly a significant increase in proinflamm...

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Bibliographic Details
Published in:	In vivo (Athens) Vol. 13; no. 6; p. 499
Main Authors:	Baronzio, G, Zambelli, A, Comi, D, Barlocco, A, Baronzio, A, Marchesi, P, Gramaglia, A, Castiglioni, E, Mafezzoni, A, Beviglia, E, Crespi, F, Cargnel, A I, Pravettoni, G
Format:	Journal Article
Language:	English
Published:	Greece 01-11-1999
Subjects:	Adult AIDS-Related Opportunistic Infections - immunology Cytokines - blood Female HIV Wasting Syndrome - immunology Humans Interleukin-1 - blood Interleukin-12 - blood Interleukin-6 - blood Linear Models Male Middle Aged Tumor Necrosis Factor-alpha - metabolism Weight Loss
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Summary:	The serum concentrations of inflammatory (Interleukin-1 beta, Tumor necrosis alpha, Interleukin-6) and regulatory cytokines (Interleukin twelve) have been studied in ten AIDS cachectic patients and compared to a control group. A cytokine imbalance, and peculiarly a significant increase in proinflammatory cytokines (Interleukin-1, Interleukin-6, Tumor necrosis Factor alpha) and a decrease in regulatory cytokines such as Interleukin-12 were found. A significant correlation resulted between weight loss and Interleukin-1 beta and 6. A negative correlation between Interleukin-1 and 12 was noted, indicating that this last cytokine has an important regulatory role also in advanced state of the disease.
ISSN:	0258-851X