Search Results - "Maeyer, Marc De"

Structural elucidation of a novel mechanism for the bacteriophage-based inhibition of the RNA degradosome by Van den Bossche, An, Hardwick, Steven W, Ceyssens, Pieter-Jan, Hendrix, Hanne, Voet, Marleen, Dendooven, Tom, Bandyra, Katarzyna J, De Maeyer, Marc, Aertsen, Abram, Noben, Jean-Paul, Luisi, Ben F, Lavigne, Rob

“…In all domains of life, the catalysed degradation of RNA facilitates rapid adaptation to changing environmental conditions, while destruction of foreign RNA is…”
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Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV by Hombrouck, Anneleen, De Rijck, Jan, Hendrix, Jelle, Vandekerckhove, Linos, Voet, Arnout, De Maeyer, Marc, Witvrouw, Myriam, Engelborghs, Yves, Christ, Frauke, Gijsbers, Rik, Debyser, Zeger

“…Retroviruses by definition insert their viral genome into the host cell chromosome. Although the key player of retroviral integration is viral integrase, a…”
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Kinases as targets for Parkinson's disease: from genetics to therapy by Vancraenenbroeck, Renee, Lobbestael, Evy, Maeyer, Marc De, Baekelandt, Veerle, Taymans, Jean-Marc

“…Intense research efforts are currently directed at elucidating the etiology of Parkinson's disease (PD). One approach that has begun to shed light on the PD…”
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Tuning the Size and Properties of ClyA Nanopores Assisted by Directed Evolution by Soskine, Misha, Biesemans, Annemie, De Maeyer, Marc, Maglia, Giovanni

“…Nanopores have recently emerged as powerful tools in single-molecule investigations. Biological nanopores, however, have drawbacks, including a fixed size and…”
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Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication by Debyser, Zeger, Christ, Frauke, Voet, Arnout, Marchand, Arnaud, Nicolet, Stefan, Desimmie, Belete A, Marchand, Damien, Bardiot, Dorothée, Van der Veken, Nam Joo, Van Remoortel, Barbara, Strelkov, Sergei V, De Maeyer, Marc, Chaltin, Patrick

“…Interaction between HIV-1 integrase and the cellular cofactor LEDGF/p75 is important for viral integration. Newly designed small molecules that block this…”
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The dead-end elimination theorem and its use in protein side-chain positioning by Desmet, Johan, Maeyer, Marc De, Hazes, Bart, Lasters, Ignace

“…The prediction of a protein's tertiary structure is still a considerable problem because the huge amount of possible conformational space¹ makes it…”
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HIV-1 Integrase Variants Retarget Viral Integration and Are Associated with Disease Progression in a Chronic Infection Cohort by Demeulemeester, Jonas, Vets, Sofie, Schrijvers, Rik, Madlala, Paradise, De Maeyer, Marc, De Rijck, Jan, Ndung’u, Thumbi, Debyser, Zeger, Gijsbers, Rik

“…Distinct integration patterns of different retroviruses, including HIV-1, have puzzled virologists for over 20 years. A tetramer of the viral integrase (IN)…”
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LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 - 2014) by Demeulemeester, Jonas, Chaltin, Patrick, Marchand, Arnaud, De Maeyer, Marc, Debyser, Zeger, Christ, Frauke

“…Integration of the viral genome into the host cell chromatin is a central step in the replication cycle of the HIV. Blocking the viral integrase (IN) enzyme…”
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‘Drc’, a structurally novel ssDNA-binding transcription regulator of N4-related bacterial viruses by Boon, Maarten, De Zitter, Elke, De Smet, Jeroen, Wagemans, Jeroen, Voet, Marleen, Pennemann, Friederike L, Schalck, Thomas, Kuznedelov, Konstantin, Severinov, Konstantin, Van Meervelt, Luc, De Maeyer, Marc, Lavigne, Rob

“…Abstract Bacterial viruses encode a vast number of ORFan genes that lack similarity to any other known proteins. Here, we present a 2.20 Å crystal structure of…”
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The Dead-End Elimination Method, Tryptophan Rotamers, and Fluorescence Lifetimes by Hellings, Mario, Maeyer, Marc De, Verheyden, Stefan, Hao, Qiang, Damme, Els J.M. Van, Peumans, Willy J., Engelborghs, Yves

“…The Dead-End Elimination method was used to identify 40 low energy microconformations of 16 tryptophan residues in eight proteins. Single Trp-mutants of these…”
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Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers by Civiero, Laura, Vancraenenbroeck, Renée, Belluzzi, Elisa, Beilina, Alexandra, Lobbestael, Evy, Reyniers, Lauran, Gao, Fangye, Micetic, Ivan, De Maeyer, Marc, Bubacco, Luigi, Baekelandt, Veerle, Cookson, Mark R, Greggio, Elisa, Taymans, Jean-Marc

“…Leucine-rich repeat kinase 1 and 2 (LRRK1 and LRRK2) are large multidomain proteins containing kinase, GTPase and multiple protein-protein interaction domains,…”
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Evidence for DNA-Binding Domain–Ligand-Binding Domain Communications in the Androgen Receptor by Helsen, Christine, Dubois, Vanessa, Verfaillie, Annelien, Young, Jacques, Trekels, Mieke, Vancraenenbroeck, Renée, De Maeyer, Marc, Claessens, Frank

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Structural basis for the high Ca²⁺ affinity of the ubiquitous SERCA2b Ca²⁺ pump by Vandecaetsbeek, Ilse, Trekels, Mieke, De Maeyer, Marc, Ceulemans, Hugo, Lescrinier, Eveline, Raeymaekers, Luc, Wuytack, Frank, Vangheluwe, Peter

“…Sarco(endo)plasmic reticulum Ca²⁺ ATPase (SERCA) Ca²⁺ transporters pump cytosolic Ca²⁺ into the endoplasmic reticulum, maintaining a Ca²⁺ gradient that…”
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Pharmacophore modeling: advances, limitations, and current utility in drug discovery by Qing, Xiaoyu, Lee, Xiao Yin, De Raeymaeker, Joren, Tame, Jeremy R.H, Zhang, Kam Y.J, De Maeyer, Marc, Voet, Arnout R.D

“…Pharmacophore modeling is a successful yet very diverse subfield of computer-aided drug design. The concept of the pharmacophore has been widely applied to the…”
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Computational Studies of the Active and Inactive Regulatory Domains of Response Regulator PhoP Using Molecular Dynamics Simulations by Qing, Xiao‐Yu, Steenackers, Hans, Venken, Tom, De Maeyer, Marc, Voet, Arnout

“…The response regulator PhoP is part of the PhoP/PhoQ two‐component system, which is responsible for regulating the expression of multiple genes involved in…”
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Identification of the LEDGF/p75 Binding Site in HIV-1 Integrase by Busschots, Katrien, Voet, Arnout, De Maeyer, Marc, Rain, Jean-Christophe, Emiliani, Stéphane, Benarous, Richard, Desender, Linda, Debyser, Zeger, Christ, Frauke

“…Lens epithelium-derived growth factor (LEDGF)/p75 is an important cellular co-factor for human immunodeficiency virus (HIV) replication. We originally…”
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Mapping the binding interface between an HIV-1 inhibiting intrabody and the viral protein Rev by Vercruysse, Thomas, Boons, Eline, Venken, Tom, Vanstreels, Els, Voet, Arnout, Steyaert, Jan, De Maeyer, Marc, Daelemans, Dirk

“…HIV-1 Rev is the key protein in the nucleocytoplasmic export and expression of the late viral mRNAs. An important aspect for its function is its ability to…”
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pKa modulation of the acid/base catalyst within GH32 and GH68: a role in substrate/inhibitor specificity? by Yuan, Shuguang, Le Roy, Katrien, Venken, Tom, Lammens, Willem, Van den Ende, Wim, De Maeyer, Marc

“…Glycoside hydrolases of families 32 (GH32) and 68 (GH68) belong to clan GH-J, containing hydrolytic enzymes (sucrose/fructans as donor substrates) and…”
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Mutations in Human Immunodeficiency Virus Type 1 Integrase Confer Resistance to the Naphthyridine L-870,810 and Cross-Resistance to the Clinical Trial Drug GS-9137 by HOMBROUCK, Anneleen, VOET, Arnout, VAN REMOORTEL, Barbara, DESADELEER, Christel, DE MAEYER, Marc, DEBYSER, Zeger, WITVROUW, Myriam

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Mechanism of Nonpolar Model Substances to Inhibit Primary Gushing Induced by Hydrophobin HFBI by Shokribousjein, Zahra, Riveros Galan, David, Losada-Pérez, Patricia, Wagner, Patrick, Lammertyn, Jeroen, Arghir, Iulia, Golreihan, Asefeh, Verachtert, Hubert, Aydın, Ahmet Alper, De Maeyer, Marc, Titze, Jean, Ilberg, Vladimír, Derdelinckx, Guy

“…In this work, the interactions of a well-studied hydrophobin with different types of nonpolar model substances and their impact on primary gushing is…”
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