Search Results - "Maeser, Pascal"

Host-Microbe Interactions: Parasitology Vol 46 by Mäser, Pascal

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100 Years of Suramin by Wiedemar, Natalie, Hauser, Dennis A, Mäser, Pascal

“…Suramin is 100 years old and is still being used to treat the first stage of acute human sleeping sickness, caused by Suramin is a multifunctional molecule…”
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Potassium transporters in plants – Involvement in K + acquisition, redistribution and homeostasis by Gierth, Markus, Mäser, Pascal

“…Potassium is a major plant nutrient which has to be accumulated in great quantity by roots and distributed throughout the plant and within plant cells…”
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Cherchez l'Electron by Maser, Pascal

“…Summary Who wouldn't want to have a drug that is activated only in the target cell? Prodrugs that are metabolically triggered inside the pathogen but not in…”
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Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story by Baker, Nicola, de Koning, Harry P, Mäser, Pascal, Horn, David

“…Melarsoprol and pentamidine represent the two main classes of drugs, the arsenicals and diamidines, historically used to treat the diseases caused by African…”
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Plant ion channels: gene families, physiology, and functional genomics analyses by Ward, John M, Mäser, Pascal, Schroeder, Julian I

“…Distinct potassium, anion, and calcium channels in the plasma membrane and vacuolar membrane of plant cells have been identified and characterized by patch…”
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Drug Repurposing in the Chemotherapy of Infectious Diseases by Hamid, Amal, Mäser, Pascal, Mahmoud, Abdelhalim Babiker

“…Repurposing is a universal mechanism for innovation, from the evolution of feathers to the invention of Velcro tape. Repurposing is particularly attractive for…”
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Inhibition of Plasmodium falciparum Hsp90 Contributes to the Antimalarial Activities of Aminoalcohol-carbazoles by Wang, Tai, Mäser, Pascal, Picard, Didier

“…Malaria caused by the protozoan parasite Plasmodium falciparum (Pf) remains a major public health problem throughout the developing world. One molecular target…”
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Comparative sphingolipidomics of disease-causing trypanosomatids reveal unique lifecycle- and taxonomy-specific lipid chemistries by Guan, Xue Li, Mäser, Pascal

“…Trypanosomatids are parasitic protozoa which cause a spectrum of diseases, including trypanosomiasis and leishmaniasis, affecting millions of humans and…”
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Novel 4-4-(4-methylpiperazin-1-yl)phenyl-6-arylpyrimidine derivatives and their antitrypanosomal activities against T.brucei by Taylor, Annie E, Hering, Moritz, Elsegood, Mark R J, Teat, Simon J, Weaver, George W, Arroo, Randolph R J, Kaiser, Marcel, Maeser, Pascal, Bhambra, Avninder S

“…Human African trypanosomiasis, or sleeping sickness, is a neglected tropical disease caused by Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense…”
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Antiparasitic agents: new drugs on the horizon by Mäser, Pascal, Wittlin, Sergio, Rottmann, Matthias, Wenzler, Tanja, Kaiser, Marcel, Brun, Reto

“…Highlights ► New drug candidates are being clinically tested against malaria and sleeping sickness. ► For malaria these are the synthetic peroxide OZ439 and…”
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Use of herbal remedies in the management of sleeping sickness in four northern provinces of Angola by Vahekeni, Nina, Neto, Pedro Menezes, Kayimbo, Malilo Kaluiji, Mäser, Pascal, Josenando, Théophile, da Costa, Esperança, Falquet, Jacques, van Eeuwijk, Peter

“…This study reports for the first time on the use of folk medicine to treat sleeping sickness and its symptoms in four endemic provinces in northern Angola. By…”
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Hygroline derivatives from Schizanthus tricolor and their anti-trypanosomatid and antiplasmodial activities by Cretton, Sylvian, Genta-Jouve, Grégory, Kaiser, Marcel, Mäser, Pascal, Muñoz, Orlando, Bürgi, Thomas, Cuendet, Muriel, Christen, Philippe

“…Chemical investigation of the alkaloid extract of the aerial parts of Schizanthus tricolor led to the targeted isolation of 26 hygroline derivatives of which…”
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Fexinidazole for Human African Trypanosomiasis, the Fruit of a Successful Public-Private Partnership by Bernhard, Sonja, Kaiser, Marcel, Burri, Christian, Mäser, Pascal

“…After 100 years of chemotherapy with impractical and toxic drugs, an oral cure for human African trypanosomiasis (HAT) is available: Fexinidazole. In this…”
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From Magic Bullet to Magic Bomb: Reductive Bioactivation of Antiparasitic Agents by Wittlin, Sergio, Mäser, Pascal

“…Paul Ehrlich coined the term “magic bullet” to describe how a drug kills the parasite inside its human host without harming the host itself. Ehrlich concluded…”
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Boswellic Acids Show In Vitro Activity against Leishmania donovani by Greve, Hippolyt L., Kaiser, Marcel, Mäser, Pascal, Schmidt, Thomas J.

“…In continuation of our search for leads from medicinal plants against protozoal pathogens, we detected antileishmanial activity in polar fractions of a…”
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Differences in Conformational Dynamics between Plasmodium falciparum and Human Hsp90 Orthologues Enable the Structure-Based Discovery of Pathogen-Selective Inhibitors by Wang, Tai, Bisson, William H, Mäser, Pascal, Scapozza, Leonardo, Picard, Didier

“…The high sequence conservation of druggable pockets of closely related proteins can make it challenging to develop selective inhibitors. We designed a new drug…”
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Induced pluripotent stem cell-derived human macrophages as an infection model for Leishmania donovani by Baert, Lore, Rudy, Serena, Pellisson, Mélanie, Doll, Thierry, Rocchetti, Romina, Kaiser, Marcel, Mäser, Pascal, Müller, Matthias

“…The parasite Leishmania donovani is one of the species causing visceral leishmaniasis in humans, a deadly infection claiming up to 40,000 lives each year. The…”
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Novel 4-[4-(4-methylpiperazin-1-yl)phenyl]-6-arylpyrimidine derivatives and their antitrypanosomal activities against T.brucei by Taylor, Annie E., Hering, Moritz, Elsegood, Mark R.J., Teat, Simon J., Weaver, George W., Arroo, Randolph R.J., Kaiser, Marcel, Maeser, Pascal, Bhambra, Avninder S.

“…[Display omitted] Human African trypanosomiasis, or sleeping sickness, is a neglected tropical disease caused by Trypanosoma brucei rhodesiense and Trypanosoma…”
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Identification of GPI anchor attachment signals by a Kohonen self-organizing map by Fankhauser, Niklaus, Mäser, Pascal

“…Motivation: Anchoring of proteins to the extracytosolic leaflet of membranes via C-terminal attachment of glycosylphosphatidylinositol (GPI) is ubiquitous and…”
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