Search Results - "Maenhoudt, Nina"
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Human blastoids model blastocyst development and implantation
Published in Nature (London) (27-01-2022)“…One week after fertilization, human embryos implant into the uterus. This event requires the embryo to form a blastocyst consisting of a sphere encircling a…”
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Protocol for establishing organoids from human ovarian cancer biopsies
Published in STAR protocols (18-06-2021)“…Ovarian cancer (OC) is the most lethal gynecological cancer. Faithful research models are indispensable to the progression of understanding OC etiology and…”
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Protease secretions by the invading blastocyst induce calcium oscillations in endometrial epithelial cells via the protease-activated receptor 2
Published in Reproductive biology and endocrinology (15-04-2023)“…Early embryo implantation is a complex phenomenon characterized by the presence of an implantation-competent blastocyst and a receptive endometrium. Embryo…”
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Fluorescence Imaging of 3D Cell Models with Subcellular Resolution
Published in Bio-protocol (20-07-2022)“…Over the past years, research has made impressive breakthroughs towards the development and implementation of 3D cell models for a wide range of applications,…”
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Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening
Published in Nature cell biology (01-08-2019)“…Endometrial disorders represent a major gynaecological burden. Current research models fail to recapitulate the nature and heterogeneity of these diseases,…”
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Modeling Endometrium Biology and Disease
Published in Journal of personalized medicine (27-06-2022)“…The endometrium, lining the uterine lumen, is highly essential for human reproduction. Its exceptional remodeling plasticity, including the transformation…”
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Developing Organoids from Ovarian Cancer as Experimental and Preclinical Models
Published in Stem cell reports (14-04-2020)“…Ovarian cancer (OC) represents the most dismal gynecological cancer. Pathobiology is poorly understood, mainly due to lack of appropriate study models…”
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