Search Results - "Maekawa, Taira"

Targeting the canonical Wnt/β‐catenin pathway in hematological malignancies by Ashihara, Eishi, Takada, Tetsuya, Maekawa, Taira

“…The canonical Wnt/β‐catenin pathway plays an important role in different developmental processes through the regulation of stem cell functions. In the…”
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Myeloid-derived suppressor cells play crucial roles in the regulation of mouse collagen-induced arthritis by Fujii, Wataru, Ashihara, Eishi, Hirai, Hideyo, Nagahara, Hidetake, Kajitani, Naoko, Fujioka, Kazuki, Murakami, Ken, Seno, Takahiro, Yamamoto, Aihiro, Ishino, Hidetaka, Kohno, Masataka, Maekawa, Taira, Kawahito, Yutaka

“…Myeloid-derived suppressor cells (MDSCs) are of myeloid origin and are able to suppress T cell responses. The role of MDSCs in autoimmune diseases remains…”
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Progressive graft fibrosis and donor‐specific human leukocyte antigen antibodies in pediatric late liver allografts by Miyagawa‐Hayashino, Aya, Yoshizawa, Atushi, Uchida, Yoichiro, Egawa, Hiroto, Yurugi, Kimiko, Masuda, Satohiro, Minamiguchi, Sachiko, Maekawa, Taira, Uemoto, Shinji, Haga, Hironori

“…The role of donor‐specific anti‐human leukocyte antigen antibodies (DSAs) that develop late after living donor liver transplantation is unknown. Seventy‐nine…”
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Non‐steady‐state hematopoiesis regulated by the C/EBPβ transcription factor by Hirai, Hideyo, Yokota, Asumi, Tamura, Akihiro, Sato, Atsushi, Maekawa, Taira

“…Steady‐state hematopoiesis responds to extracellular stimuli to meet changing demands and also to pathologically altered intracellular signaling. Granulocyte…”
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Impact of 2 Gy γ-irradiation on the hallmark characteristics of human bone marrow-derived MSCs by Iwasa, Masaki, Fujii, Sumie, Fujishiro, Aya, Maekawa, Taira, Andoh, Akira, Takaori-Kondo, Akifumi, Ichinohe, Tatsuo, Miura, Yasuo

“…Two gray γ-irradiation is a widely employed basic module for total body irradiation (TBI) in allogeneic hematopoietic cell transplantation (HCT). The effects…”
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Menatetrenone facilitates hematopoietic cell generation in a manner that is dependent on human bone marrow mesenchymal stromal/stem cells by Fujishiro, Aya, Iwasa, Masaki, Fujii, Sumie, Maekawa, Taira, Andoh, Akira, Tohyama, Kaoru, Takaori-Kondo, Akifumi, Miura, Yasuo

“…Vitamin K2 in the form of menatetrenone has clinical benefits for osteoporosis and cytopenia. Given the dominant role of mesenchymal-osteolineage cells in the…”
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Two Susceptibility Loci to Takayasu Arteritis Reveal a Synergistic Role of the IL12B and HLA-B Regions in a Japanese Population by Terao, Chikashi, Yoshifuji, Hajime, Kimura, Akinori, Matsumura, Takayoshi, Ohmura, Koichiro, Takahashi, Meiko, Shimizu, Masakazu, Kawaguchi, Takahisa, Chen, Zhiyong, Naruse, Taeko K., Sato-Otsubo, Aiko, Ebana, Yusuke, Maejima, Yasuhiro, Kinoshita, Hideyuki, Murakami, Kosaku, Kawabata, Daisuke, Wada, Yoko, Narita, Ichiei, Tazaki, Junichi, Kawaguchi, Yasushi, Yamanaka, Hisashi, Yurugi, Kimiko, Miura, Yasuo, Maekawa, Taira, Ogawa, Seishi, Komuro, Issei, Nagai, Ryozo, Yamada, Ryo, Tabara, Yasuharu, Isobe, Mitsuaki, Mimori, Tsuneyo, Matsuda, Fumihiko

“…Takayasu arteritis (TAK) is an autoimmune systemic vasculitis of unknown etiology. Although previous studies have revealed that HLA-B∗52:01 has an effect on…”
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A Clinical, Pathological, and Genetic Characterization of Methotrexate-associated Lymphoproliferative Disorders by YAMAKAWA, Noriyuki, FUJIMOTO, Masakazu, FUJII, Takao, KITANO, Toshiyuki, KONDO, Tadakazu, YURUGI, Kimiko, MIURA, Yasuo, MAEKAWA, Taira, SAJI, Hiroh, TAKAORI-KONDO, Akifumi, MATSUDA, Fumihiko, HAGA, Hironori, KAWABATA, Daisuke, MIMORI, Tsuneyo, TERAO, Chikashi, NISHIKORI, Momoko, NAKASHIMA, Ran, IMURA, Yoshitaka, YUKAWA, Naoichiro, YOSHIFUJI, Hajime, OHMURA, Koichiro

“…Methotrexate-associated lymphoproliferative disorders (MTX-LPD) often regress spontaneously during MTX withdrawal, but the prognostic factors remain unclear…”
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Ethics for clinical research by Maekawa, Taira

“…In order to translate research results obtained with technical innovations into the novel therapeutic approaches expeditiously, it is mandatory that both…”
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Research ethics and conflicts of interest by Maekawa, Taira

“…Translating research results to clinical settings requires that both researchers and clinicians work together with pharmaceutical companies. At the same time,…”
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Accelerated apoptosis of peripheral blood monocytes in Cebpb-deficient mice by Tamura, Akihiro, Hirai, Hideyo, Yokota, Asumi, Sato, Atsushi, Shoji, Tsukimi, Kashiwagi, Takahiro, Iwasa, Masaki, Fujishiro, Aya, Miura, Yasuo, Maekawa, Taira

“…The CCAAT/enhancer-binding protein β (C/EBPβ) transcription factor is required for granulopoiesis under stress conditions. However, little is known about its…”
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Genotyping of relapsing polychondritis identified novel susceptibility HLA alleles and distinct genetic characteristics from other rheumatic diseases by Terao, Chikashi, Yoshifuji, Hajime, Yamano, Yoshihisa, Kojima, Hiroto, Yurugi, Kimiko, Miura, Yasuo, Maekawa, Taira, Handa, Hiroshi, Ohmura, Koichiro, Saji, Hiroh, Mimori, Tsuneyo, Matsuda, Fumihiko

“…To uncover the genetic background of relapsing polychondritis (RPC), a rare autoimmune disease with unknown mechanisms characterized by systemic inflammation…”
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Combination of panobinostat with ponatinib synergistically overcomes imatinib‐resistant CML cells by Matsuda, Yasufumi, Yamauchi, Takahiro, Hosono, Naoko, Uzui, Kanako, Negoro, Eiju, Morinaga, Koji, Nishi, Rie, Yoshida, Akira, Kimura, Shinya, Maekawa, Taira, Ueda, Takanori

“…The major mechanism of imatinib (IM) resistance of CML is the reactivation of ABL kinase either through BCR‐ABL gene amplification or mutation. We investigated…”
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CCR1-mediated accumulation of myeloid cells in the liver microenvironment promoting mouse colon cancer metastasis by Hirai, Hideyo, Fujishita, Teruaki, Kurimoto, Kazuki, Miyachi, Hitoshi, Kitano, Satsuki, Inamoto, Susumu, Itatani, Yoshiro, Saitou, Mitinori, Maekawa, Taira, Taketo, M. Mark

“…To understand colon cancer metastasis, we earlier analyzed a mouse model that developed liver metastasis of cancer cells disseminated from the spleen. We…”
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Galectin-3 (Gal-3) induced by leukemia microenvironment promotes drug resistance and bone marrow lodgment in chronic myelogenous leukemia by Yamamoto-Sugitani, Mio, Kuroda, Junya, Ashihara, Eishi, Nagoshi, Hisao, Kobayashi, Tsutomu, Matsumoto, Yosuke, Sasaki, Nana, Shimura, Yuji, Kiyota, Miki, Nakayama, Ryuko, Akaji, Kenichi, Taki, Tomohiko, Uoshima, Nobuhiko, Kobayashi, Yutaka, Horiike, Shigeo, Maekawa, Taira, Taniwaki, Masafumi

“…Bone marrow (BM) microenvironment (BMME) constitutes the sanctuary for leukemic cells. In this study, we investigated the molecular mechanisms for…”
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Future prospect of RNA interference for cancer therapies by Ashihara, Eishi, Kawata, Eri, Maekawa, Taira

“…RNA interference (RNAi) is a phenomenon of sequence-specific gene silencing in mammalian cells and its discovery has lead to its wide application as a powerful…”
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In‐hospital mortality in adult recipients of living donor liver transplantation: Experience of 576 consecutive cases at a single center by Kaido, Toshimi, Egawa, Hiroto, Tsuji, Hiroaki, Ashihara, Eishi, Maekawa, Taira, Uemoto, Shinji

“…Adult living donor liver transplantation (LDLT) was developed against the background of a scarcity of deceased donors and has a number of disadvantages leading…”
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HLA-DRB1 Analysis Identified a Genetically Unique Subset within Rheumatoid Arthritis and Distinct Genetic Background of Rheumatoid Factor Levels from Anticyclic Citrullinated Peptide Antibodies by Hiwa, Ryosuke, Ikari, Katsunori, Ohmura, Koichiro, Nakabo, Shuichiro, Matsuo, Keitaro, Saji, Hiroh, Yurugi, Kimiko, Miura, Yasuo, Maekawa, Taira, Taniguchi, Atsuo, Yamanaka, Hisashi, Matsuda, Fumihiko, Mimori, Tsuneyo, Terao, Chikashi

“…is the most important locus associated with rheumatoid arthritis (RA) and anticitrullinated protein antibodies (ACPA). However, fluctuations of rheumatoid…”
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Conflicts-of-interests in medical research: its management and current status by Maekawa, Taira

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Co-occurrence of relapsing polychondritis and autoimmune thyroid diseases by Nakajima, Toshiki, Yoshifuji, Hajime, Yamano, Yoshihisa, Yurugi, Kimiko, Miura, Yasuo, Maekawa, Taira, Yoshida, Tsuneyasu, Handa, Hiroshi, Ohmura, Koichiro, Mimori, Tsuneyo, Terao, Chikashi

“…Relapsing polychondritis (RP) is a rare inflammatory disease characterized by recurrent inflammation and destruction of cartilaginous tissues. RP has…”
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