Search Results - "Maekawa, Ryo"

Importance of Melatonin in Assisted Reproductive Technology and Ovarian Aging by Tamura, Hiroshi, Jozaki, Mai, Tanabe, Manabu, Shirafuta, Yuichiro, Mihara, Yumiko, Shinagawa, Masahiro, Tamura, Isao, Maekawa, Ryo, Sato, Shun, Taketani, Toshiaki, Takasaki, Akihisa, Reiter, Russel J, Sugino, Norihiro

“…Melatonin is probably produced in all cells but is only secreted by the pineal gland. The pineal secretion of melatonin is determined by the light-dark cycle,…”
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Long‐term melatonin treatment delays ovarian aging by Tamura, Hiroshi, Kawamoto, Mai, Sato, Shun, Tamura, Isao, Maekawa, Ryo, Taketani, Toshiaki, Aasada, Hiromi, Takaki, Eiichi, Nakai, Akira, Reiter, Russel J., Sugino, Norihiro

“…Ovarian aging is characterized by gradual declines in oocyte quantity and quality. Melatonin is considered an anti‐aging agent due to its cytoprotective…”
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Melatonin as a free radical scavenger in the ovarian follicle [Review] by Tamura, Hiroshi, Takasaki, Akihisa, Taketani, Toshiaki, Tanabe, Manabu, Kizuka, Fumie, Lee, Lifa, Tamura, Isao, Maekawa, Ryo, Asada, Hiromi, Yamagata, Yoshiaki, Sugino, Norihiro

“…This review summarizes new findings related to beneficial effects of melatonin (N-acetyl-5-methoxytryptamine) on reproductive physiology. Recently many…”
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Different DNA methylome, transcriptome and histological features in uterine fibroids with and without MED12 mutations by Maekawa, Ryo, Sato, Shun, Tamehisa, Tetsuro, Sakai, Takahiro, Kajimura, Takuya, Sueoka, Kotaro, Sugino, Norihiro

“…Somatic mutations in Mediator complex subunit 12 (MED12m) have been reported as a biomarker of uterine fibroids (UFs). However, the role of MED12m is still…”
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Correction: Genome-wide DNA methylation analysis revealed stable DNA methylation status during decidualization in human endometrial stromal cells by Maekawa, Ryo, Tamura, Isao, Shinagawa, Masahiro, Mihara, Yumiko, Sato, Shun, Okada, Maki, Taketani, Toshiaki, Tamura, Hiroshi, Sugino, Norihiro

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Melatonin and female reproduction by Tamura, Hiroshi, Takasaki, Akihisa, Taketani, Toshiaki, Tanabe, Manabu, Lee, Lifa, Tamura, Isao, Maekawa, Ryo, Aasada, Hiromi, Yamagata, Yoshiaki, Sugino, Norihiro

“…Melatonin (N‐acetyl‐5‐methoxytryptamine) is secreted during the dark hours at night by the pineal gland. After entering the circulation, melatonin acts as an…”
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The distal upstream region of insulin-like growth factor–binding protein-1 enhances its expression in endometrial stromal cells during decidualization by Tamura, Isao, Jozaki, Kosuke, Sato, Shun, Shirafuta, Yuichiro, Shinagawa, Masahiro, Maekawa, Ryo, Taketani, Toshiaki, Asada, Hiromi, Tamura, Hiroshi, Sugino, Norihiro

“…We have previously shown that decidualization of human endometrial stromal cells (ESCs) causes a genome-wide increase in the levels of acetylation of…”
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Differential gene expression in decidualized human endometrial stromal cells induced by different stimuli by Doi-Tanaka, Yumiko, Tamura, Isao, Shiroshita, Amon, Fujimura, Taishi, Shirafuta, Yuichiro, Maekawa, Ryo, Taketani, Toshiaki, Sato, Shun, Sugino, Norihiro

“…Decidualization can be induced by culturing human endometrial stromal cells (ESCs) with several decidualization stimuli, such as cAMP, medroxyprogesterone…”
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Asymmetrical hybridization between Trillium apetalon and T. tschonoskii for the formation of a hybrid T. miyabeanum (Melanthiaceae) by Maekawa, Ryo, Mitani, Takuya, Ishizaki, Satomi, Kubota, Shosei, Ohara, Masashi

“…Trillium apetalon (4×) and T. tschonoskii (4×) hybridize commonly where both species grow sympatrically, leading to the formation of tetraploid T. miyabeanum…”
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Genome-wide DNA methylation analysis revealed stable DNA methylation status during decidualization in human endometrial stromal cells by Maekawa, Ryo, Tamura, Isao, Shinagawa, Masahiro, Mihara, Yumiko, Sato, Shun, Okada, Maki, Taketani, Toshiaki, Tamura, Hiroshi, Sugino, Norihiro

“…During decidualization in endometrial stromal cells (ESCs), expressions of a number of genes and epigenetic modifications of histones are altered. However,…”
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The role of melatonin as an antioxidant in the follicle by Tamura, Hiroshi, Takasaki, Akihisa, Taketani, Toshiaki, Tanabe, Manabu, Kizuka, Fumie, Lee, Lifa, Tamura, Isao, Maekawa, Ryo, Aasada, Hiromi, Yamagata, Yoshiaki, Sugino, Norihiro

“…Melatonin (N-acetyl-5-methoxytryptamine) is secreted during the dark hours at night by pineal gland, and it regulates a variety of important central and…”
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Genome-wide DNA methylation profiling in cultured eutopic and ectopic endometrial stromal cells by Yamagata, Yoshiaki, Nishino, Koichiro, Takaki, Eiichi, Sato, Shun, Maekawa, Ryo, Nakai, Akira, Sugino, Norihiro

“…The objective of this study was to characterize the genome-wide DNA methylation profiles of isolated endometrial stromal cells obtained from eutopic endometria…”
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National survey of abnormal uterine bleeding according to the FIGO classification in Japan by Kitahara, Yoshikazu, Hiraike, Osamu, Ishikawa, Hiroshi, Kugu, Koji, Takai, Yasushi, Yoshino, Osamu, Ono, Masanori, Maekawa, Ryo, Ota, Ikuko, Iwase, Akira

“…Aim To investigate the status of abnormal uterine bleeding (AUB) in Japan using the International Federation of Gynecology and Obstetrics (FIGO) classification…”
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Melatonin protects the integrity of granulosa cells by reducing oxidative stress in nuclei, mitochondria, and plasma membranes in mice by TANABE, Manabu, TAMURA, Hiroshi, TAKETANI, Toshiaki, OKADA, Maki, LEE, Lifa, TAMURA, Isao, MAEKAWA, Ryo, ASADA, Hiromi, YAMAGATA, Yoshiaki, SUGINO, Norihiro

“…Melatonin protects luteinized granulosa cells (GCs) from oxidative stress in the follicle during ovulation. However, it is unclear in which cellular components…”
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Integrated Analysis of Transcriptome and Histone Modifications in Granulosa Cells During Ovulation in Female Mice by Shirafuta, Yuichiro, Tamura, Isao, Ohkawa, Yasuyuki, Maekawa, Ryo, Doi-Tanaka, Yumiko, Takagi, Haruka, Mihara, Yumiko, Shinagawa, Masahiro, Taketani, Toshiaki, Sato, Shun, Tamura, Hiroshi, Sugino, Norihiro

“…The ovulatory luteinizing hormone (LH) surge induces rapid changes of gene expression and cellular functions in granulosa cells (GCs) undergoing luteinization…”
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Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate by Tamura, Hiroshi, Takasaki, Akihisa, Miwa, Ichiro, Taniguchi, Ken, Maekawa, Ryo, Asada, Hiromi, Taketani, Toshiaki, Matsuoka, Aki, Yamagata, Yoshiaki, Shimamura, Katsunori, Morioka, Hitoshi, Ishikawa, Hitoshi, Reiter, Russel J., Sugino, Norihiro

“…:  We investigated the relationship between oxidative stress and poor oocyte quality and whether the antioxidant melatonin improves oocyte quality. Follicular…”
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An Integrated Genomic Approach Identifies HOXC8 as an Upstream Regulator in Ovarian Endometrioma by Mihara, Yumiko, Maekawa, Ryo, Sato, Shun, Shimizu, Natsuko, Doi-Tanaka, Yumiko, Takagi, Haruka, Shirafuta, Yuichiro, Shinagawa, Masahiro, Tamura, Isao, Taketani, Toshiaki, Tamura, Hiroshi, Abe, Takeshi, Asai, Yoshiyuki, Sugino, Norihiro

“…Abstract Purpose To identify the upstream regulators (URs) involved in the onset and pathogenesis of ovarian endometrioma. Methods Recently, a method called…”
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Wilms tumor 1 regulates lipid accumulation in human endometrial stromal cells during decidualization by Tamura, Isao, Takagi, Haruka, Doi-Tanaka, Yumiko, Shirafuta, Yuichiro, Mihara, Yumiko, Shinagawa, Masahiro, Maekawa, Ryo, Taketani, Toshiaki, Sato, Shun, Tamura, Hiroshi, Sugino, Norihiro

“…We previously reported that the transcription factor Wilms tumor 1 (WT1) regulates the expression of insulin-like growth factor-binding protein-1 (IGFBP-1) and…”
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Genome-wide DNA methylation analysis reveals a potential mechanism for the pathogenesis and development of uterine leiomyomas by Maekawa, Ryo, Sato, Shun, Yamagata, Yoshiaki, Asada, Hiromi, Tamura, Isao, Lee, Lifa, Okada, Maki, Tamura, Hiroshi, Takaki, Eiichi, Nakai, Akira, Sugino, Norihiro

“…The pathogenesis of uterine leiomyomas, the most common benign tumor in women, remains unclear. Since acquired factors such as obesity, hypertension and early…”
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Changes in Histone Modification and DNA Methylation of the StAR and Cyp19a1 Promoter Regions in Granulosa Cells Undergoing Luteinization during Ovulation In Rats by Lee, Lifa, Asada, Hiromi, Kizuka, Fumie, Tamura, Isao, Maekawa, Ryo, Taketani, Toshiaki, Sato, Shun, Yamagata, Yoshiaki, Tamura, Hiroshi, Sugino, Norihiro

“…The ovulatory LH surge induces rapid up-regulation of steroidogenic acute regulatory (StAR) protein and rapid down-regulation of aromatase (Cyp19a1) in…”
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