Search Results - "Maehr, Rene"

Systematic evaluation of chromosome conformation capture assays by Akgol Oksuz, Betul, Yang, Liyan, Abraham, Sameer, Venev, Sergey V., Krietenstein, Nils, Parsi, Krishna Mohan, Ozadam, Hakan, Oomen, Marlies E., Nand, Ankita, Mao, Hui, Genga, Ryan M. J., Maehr, Rene, Rando, Oliver J., Mirny, Leonid A., Gibcus, Johan H., Dekker, Job

“…Chromosome conformation capture (3C) assays are used to map chromatin interactions genome-wide. Chromatin interaction maps provide insights into the spatial…”
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Inferring population dynamics from single-cell RNA-sequencing time series data by Fischer, David S., Fiedler, Anna K., Kernfeld, Eric M., Genga, Ryan M. J., Bastidas-Ponce, Aimée, Bakhti, Mostafa, Lickert, Heiko, Hasenauer, Jan, Maehr, Rene, Theis, Fabian J.

“…Recent single-cell RNA-sequencing studies have suggested that cells follow continuous transcriptomic trajectories in an asynchronous fashion during…”
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Mesenchymal Stromal Cell-Derived Extracellular Vesicles Restore Thymic Architecture and T Cell Function Disrupted by Neonatal Hyperoxia by Reis, Monica, Willis, Gareth R, Fernandez-Gonzalez, Angeles, Yeung, Vincent, Taglauer, Elizabeth, Magaletta, Margaret, Parsons, Teagan, Derr, Alan, Liu, Xianlan, Maehr, Rene, Kourembanas, Stella, Mitsialis, S Alex

“…Treating premature infants with high oxygen is a routine intervention in the context of neonatal intensive care. Unfortunately, the increase in survival rates…”
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De novo formation of insulin-producing "neo-β cell islets" from intestinal crypts by Chen, Yi-Ju, Finkbeiner, Stacy R, Weinblatt, Daniel, Emmett, Matthew J, Tameire, Feven, Yousefi, Maryam, Yang, Chenghua, Maehr, Rene, Zhou, Qiao, Shemer, Ruth, Dor, Yuval, Li, Changhong, Spence, Jason R, Stanger, Ben Z

“…The ability to interconvert terminally differentiated cells could serve as a powerful tool for cell-based treatment of degenerative diseases, including…”
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Ultrastructural Details of Mammalian Chromosome Architecture by Krietenstein, Nils, Abraham, Sameer, Venev, Sergey V., Abdennur, Nezar, Gibcus, Johan, Hsieh, Tsung-Han S., Parsi, Krishna Mohan, Yang, Liyan, Maehr, René, Mirny, Leonid A., Dekker, Job, Rando, Oliver J.

“…Over the past decade, 3C-related methods have provided remarkable insights into chromosome folding in vivo. To overcome the limited resolution of prior…”
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Functional annotation of native enhancers with a Cas9–histone demethylase fusion by Kearns, Nicola A, Pham, Hannah, Tabak, Barbara, Genga, Ryan M, Silverstein, Noah J, Garber, Manuel, Maehr, René

“…Targeting a histone demethylase to specific enhancers with Cas9 allows modification of epigenetic marks at the enhancers. Understanding of mammalian enhancers…”
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SARS-CoV-2 Initiates Programmed Cell Death in Platelets by Koupenova, Milka, Corkrey, Heather A., Vitseva, Olga, Tanriverdi, Kahraman, Somasundaran, Mohan, Liu, Ping, Soofi, Shaukat, Bhandari, Rohan, Godwin, Matthew, Parsi, Krishna Mohan, Cousineau, Alyssa, Maehr, René, Wang, Jennifer P., Cameron, Scott J., Rade, Jeffrey, Finberg, Robert W., Freedman, Jane E.

“…[Figure: see text]…”
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Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds by Chen, Alice E, Guo, Wenjun, Melton, Douglas A, Snitow, Melinda, Maehr, René, Huangfu, Danwei, Eijkelenboom, Astrid

“…Reprogramming of mouse and human somatic cells can be achieved by ectopic expression of transcription factors, but with low efficiencies. We report that DNA…”
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A Single-Cell Transcriptomic Atlas of Thymus Organogenesis Resolves Cell Types and Developmental Maturation by Kernfeld, Eric M., Genga, Ryan M.J., Neherin, Kashfia, Magaletta, Margaret E., Xu, Ping, Maehr, René

“…Thymus development is critical to the adaptive immune system, yet a comprehensive transcriptional framework capturing thymus organogenesis at single-cell…”
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Diverse repertoire of human adipocyte subtypes develops from transcriptionally distinct mesenchymal progenitor cells by Min, So Yun, Desai, Anand, Yang, Zinger, Sharma, Agastya, DeSouza, Tiffany, Genga, Ryan M. J., Kucukural, Alper, Lifshitz, Lawrence M., Nielsen, Søren, Scheele, Camilla, Maehr, René, Garber, Manuel, Corvera, Silvia

“…Single-cell sequencing technologies have revealed an unexpectedly broad repertoire of cells required to mediate complex functions in multicellular organisms…”
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Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells by Kearns, Nicola A, Genga, Ryan M J, Enuameh, Metewo S, Garber, Manuel, Wolfe, Scot A, Maehr, René

“…The identification of the trans-acting factors and cis-regulatory modules that are involved in human pluripotent stem cell (hPSC) maintenance and…”
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Integration of single-cell transcriptomes and chromatin landscapes reveals regulatory programs driving pharyngeal organ development by Magaletta, Margaret E., Lobo, Macrina, Kernfeld, Eric M., Aliee, Hananeh, Huey, Jack D., Parsons, Teagan J., Theis, Fabian J., Maehr, René

“…Maldevelopment of the pharyngeal endoderm, an embryonic tissue critical for patterning of the pharyngeal region and ensuing organogenesis, ultimately…”
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Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2 by Melton, Douglas A, Guo, Wenjun, Muhlestein, Whitney, Osafune, Kenji, Maehr, René, Huangfu, Danwei, Eijkelenboom, Astrid, Chen, Shuibing

“…One strategy for advancing induced pluripotent stem (iPS) cell technology toward the clinic is to replace the reprogramming genes with small molecules. Huangfu…”
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Generation of pluripotent stem cells from patients with type 1 diabetes by Maehr, René, Chen, Shuibing, Snitow, Melinda, Ludwig, Thomas, Yagasaki, Lisa, Goland, Robin, Leibel, Rudolph L, Melton, Douglas A

“…Type 1 diabetes (T1D) is the result of an autoimmune destruction of pancreatic β cells. The cellular and molecular defects that cause the disease remain…”
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Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development by Genga, Ryan M.J., Kernfeld, Eric M., Parsi, Krishna M., Parsons, Teagan J., Ziller, Michael J., Maehr, René

“…Studies in vertebrates have outlined conserved molecular control of definitive endoderm (END) development. However, recent work also shows that key molecular…”
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Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway by Blum, Barak, Roose, Adam N, Barrandon, Ornella, Maehr, René, Arvanites, Anthony C, Davidow, Lance S, Davis, Jeffrey C, Peterson, Quinn P, Rubin, Lee L, Melton, Douglas A

“…Dysfunction or death of pancreatic β cells underlies both types of diabetes. This functional decline begins with β cell stress and de-differentiation. Current…”
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Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes by Babon, Jenny Aurielle B, DeNicola, Megan E, Blodgett, David M, Crèvecoeur, Inne, Buttrick, Thomas S, Maehr, René, Bottino, Rita, Naji, Ali, Kaddis, John, Elyaman, Wassim, James, Eddie A, Haliyur, Rachana, Brissova, Marcela, Overbergh, Lut, Mathieu, Chantal, Delong, Thomas, Haskins, Kathryn, Pugliese, Alberto, Campbell-Thompson, Martha, Mathews, Clayton, Atkinson, Mark A, Powers, Alvin C, Harlan, David M, Kent, Sally C

“…Analysis of T cells isolated from patients with and without type 1 diabetes reveals reactivity to a range of native as well as post-translationally modified…”
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Mechanism-Based Probe for the Analysis of Cathepsin Cysteine Proteases in Living Cells by Hang, Howard C, Loureiro, Joana, Spooner, Eric, van der Velden, Adrianus W. M, Kim, You-Me, Pollington, Annette M, Maehr, Rene, Starnbach, Michael N, Ploegh, Hidde L

“…Mechanism-based probes are providing new tools to evaluate the enzymatic activities of protein families in complex mixtures and to assign protein function. The…”
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A small molecule that directs differentiation of human ESCs into the pancreatic lineage by Melton, Douglas, Chen, Shuibing, Borowiak, Malgorzata, Fox, Julia L, Maehr, René, Osafune, Kenji, Davidow, Lance, Lam, Kelvin, Peng, Lee F, Schreiber, Stuart L, Rubin, Lee L

“…Stepwise differentiation from embryonic stem cells (ESCs) to functional insulin-secreting beta cells will identify key steps in beta-cell development and may…”
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Small Molecules Efficiently Direct Endodermal Differentiation of Mouse and Human Embryonic Stem Cells by Borowiak, Malgorzata, Maehr, René, Chen, Shuibing, Chen, Alice E., Tang, Weiping, Fox, Julia L., Schreiber, Stuart L., Melton, Douglas A.

“…An essential step for therapeutic and research applications of stem cells is the ability to differentiate them into specific cell types. Endodermal cell…”
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