The first total synthesis of (−)-mitragynine, an analgesic indole alkaloid in mitragyna speciosa

The first total synthesis of (−)-mitragynine, an analgesic indole alkaloid in mitragyna speciosa

Starting from an optically pure alcohol, ( R)-( 3), which was prepared by enzymatic hydrolysis of the racemic acetate ( 2) or enantioselective reduction of the ketone derivative ( 4), the chiral total synthesis of mitragynine ( 1), a major corynanthe-type indole alkaloid having an analgesic effect i...

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Bibliographic Details
Published in:Tetrahedron letters Vol. 36; no. 51; pp. 9337 - 9340
Main Authors: Takayama, Hiromitsu, Maeda, Moriyoshi, Ohbayashi, Satoshi, Kitajima, Mariko, Sakai, Shin-ichiro, Aimi, Norio
Format: Journal Article
Language:English
Published: Elsevier Ltd 18-12-1995
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Summary:Starting from an optically pure alcohol, ( R)-( 3), which was prepared by enzymatic hydrolysis of the racemic acetate ( 2) or enantioselective reduction of the ketone derivative ( 4), the chiral total synthesis of mitragynine ( 1), a major corynanthe-type indole alkaloid having an analgesic effect in Mitragyna speciosa, was accomplished.
ISSN:0040-4039
1873-3581
DOI:10.1016/0040-4039(95)02022-H