Search Results - "Maebius, Allison"
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The mitochondrial NADH pool is involved in hydrogen sulfide signaling and stimulation of aerobic glycolysis
Published in The Journal of biological chemistry (01-01-2021)“…Hydrogen sulfide is synthesized by enzymes involved in sulfur metabolism and oxidized via a dedicated mitochondrial pathway that intersects with the electron…”
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Low NCOR2 levels in multiple myeloma patients drive multidrug resistance via MYC upregulation
Published in Blood cancer journal (New York) (04-12-2021)“…MYC upregulation is associated with multidrug refractory disease in patients with multiple myeloma (MM). We, isolated patient-derived MM cells with high MYC…”
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Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin
Published in Nature communications (04-11-2023)“…Inhibition of Janus kinase (JAK) family enzymes is a popular strategy for treating inflammatory and autoimmune skin diseases. In the clinic, small molecule JAK…”
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Multiple myeloma cells induce lipolysis in adipocytes and uptake fatty acids through fatty acid transporter proteins
Published in Blood (10-02-2022)“…Adipocytes occupy 70% of the cellular volume within the bone marrow (BM) wherein multiple myeloma (MM) originates and resides. However, the nature of the…”
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Bone Marrow Adipocytes Induce Metabolic Reprogramming of Multiple Myeloma Cells
Published in Blood (23-11-2021)“…Obesity-induced increases in bone marrow adipocyte (BMAd) numbers and volume are associated with an increased risk of multiple myeloma (MM). We analyzed gene…”
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Mature Osteoblasts Are Critical Bone Marrow Niche Cells Regulating Multiple Myeloma Cell Growth, at Least in Part, By Affecting the Local Immune Microenvironment
Published in Blood (23-11-2021)“…Despite high response rates to new therapies, most multiple myeloma (MM) patients relapse and become refractory to treatment. This is likely because MM cells…”
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Reprogramming of Colonic Cell Metabolism by H2S
Published in The FASEB journal (01-04-2019)“…Synthesis of H2S by gut microbiota leads to routine colonic cells exposure to this respiratory toxin. Herein we studied the effect of H2S on metabolism and…”
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Reprogramming of Colonic Cell Metabolism by H 2 S
Published in The FASEB journal (01-04-2019)“…Abstract only Synthesis of H 2 S by gut microbiota leads to routine colonic cells exposure to this respiratory toxin. Herein we studied the effect of H 2 S on…”
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OAB-029: Bone marrow adipocytes induce metabolic reprogramming of multiple myeloma cells
Published in Clinical lymphoma, myeloma and leukemia (01-10-2021)“…Obesity-induced increases in bone marrow adipocyte (BMAd) numbers and volume are associated with an increased risk of MM. However, the associated molecular…”
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OAB-045: COVID-19 vaccine responsiveness in patients with Multiple Myeloma and Waldenström Macroglobulinemia
Published in Clinical lymphoma, myeloma and leukemia (01-10-2021)“…Multiple myeloma (MM) and Waldenström macroglobulinemia (WM) are associated with significant immunoparesis. Based on the ongoing COVID-19 pandemic, there is an…”
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