Search Results - "Madzo, Jozef"

TET1-Mediated Hypomethylation Activates Oncogenic Signaling in Triple-Negative Breast Cancer by Good, Charly Ryan, Panjarian, Shoghag, Kelly, Andrew D, Madzo, Jozef, Patel, Bela, Jelinek, Jaroslav, Issa, Jean-Pierre J

“…Both gains and losses of DNA methylation are common in cancer, but the factors controlling this balance of methylation remain unclear. Triple-negative breast…”
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The three-dimensional structure of Epstein-Barr virus genome varies by latency type and is regulated by PARP1 enzymatic activity by Morgan, Sarah M., Tanizawa, Hideki, Caruso, Lisa Beatrice, Hulse, Michael, Kossenkov, Andrew, Madzo, Jozef, Keith, Kelsey, Tan, Yinfei, Boyle, Sarah, Lieberman, Paul M., Tempera, Italo

“…Epstein-Barr virus (EBV) persists in human B-cells by maintaining its chromatinized episomes within the nucleus. We have previously shown that cellular factor…”
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Caloric restriction delays age-related methylation drift by Maegawa, Shinji, Lu, Yue, Tahara, Tomomitsu, Lee, Justin T., Madzo, Jozef, Liang, Shoudan, Jelinek, Jaroslav, Colman, Ricki J., Issa, Jean-Pierre J.

“…In mammals, caloric restriction consistently results in extended lifespan. Epigenetic information encoded by DNA methylation is tightly regulated, but shows a…”
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Transcriptional Selectivity of Epigenetic Therapy in Cancer by Sato, Takahiro, Cesaroni, Matteo, Chung, Woonbok, Panjarian, Shoghag, Tran, Anthony, Madzo, Jozef, Okamoto, Yasuyuki, Zhang, Hanghang, Chen, Xiaowei, Jelinek, Jaroslav, Issa, Jean-Pierre J

“…A central challenge in the development of epigenetic cancer therapy is the ability to direct selectivity in modulating gene expression for disease-selective…”
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Single cell transcriptomic analysis reveals cellular diversity of murine esophageal epithelium by Kabir, Mohammad Faujul, Karami, Adam L., Cruz-Acuña, Ricardo, Klochkova, Alena, Saxena, Reshu, Mu, Anbin, Murray, Mary Grace, Cruz, Jasmine, Fuller, Annie D., Clevenger, Margarette H., Chitrala, Kumaraswamy Naidu, Tan, Yinfei, Keith, Kelsey, Madzo, Jozef, Huang, Hugh, Jelinek, Jaroslav, Karakasheva, Tatiana, Hamilton, Kathryn E., Muir, Amanda B., Tétreault, Marie-Pier, Whelan, Kelly A.

“…Although morphologic progression coupled with expression of specific molecular markers has been characterized along the esophageal squamous differentiation…”
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Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation by Moran-Crusio, Kelly, Reavie, Linsey, Shih, Alan, Abdel-Wahab, Omar, Ndiaye-Lobry, Delphine, Lobry, Camille, Figueroa, Maria E., Vasanthakumar, Aparna, Patel, Jay, Zhao, Xinyang, Perna, Fabiana, Pandey, Suveg, Madzo, Jozef, Song, Chunxiao, Dai, Qing, He, Chuan, Ibrahim, Sherif, Beran, Miloslav, Zavadil, Jiri, Nimer, Stephen D., Melnick, Ari, Godley, Lucy A., Aifantis, Iannis, Levine, Ross L.

“…Somatic loss-of-function mutations in the ten-eleven translocation 2 ( TET2) gene occur in a significant proportion of patients with myeloid malignancies…”
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Ezh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity by He, Shan, Liu, Yongnian, Meng, Lijun, Sun, Hongxing, Wang, Ying, Ji, Yun, Purushe, Janaki, Chen, Pan, Li, Changhong, Madzo, Jozef, Issa, Jean-Pierre, Soboloff, Jonathan, Reshef, Ran, Moore, Bethany, Gattinoni, Luca, Zhang, Yi

“…Memory T cells sustain effector T-cell production while self-renewing in reaction to persistent antigen; yet, excessive expansion reduces memory potential and…”
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DNA methylation entropy as a measure of stem cell replication and aging by Vaidya, Himani, Jeong, Hye Seon, Keith, Kelsey, Maegawa, Shinji, Calendo, Gennaro, Madzo, Jozef, Jelinek, Jaroslav, Issa, Jean-Pierre J

“…Epigenetic marks are encoded by DNA methylation and accumulate errors as organisms age. This drift correlates with lifespan, but the biology of how this occurs…”
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Poly(ADP-ribose) polymerase 1 is necessary for coactivating hypoxia-inducible factor-1-dependent gene expression by Epstein-Barr virus latent membrane protein 1 by Hulse, Michael, Caruso, Lisa B, Madzo, Jozef, Tan, Yinfei, Johnson, Sarah, Tempera, Italo

“…Latent membrane protein 1 (LMP1) is the major transforming protein of Epstein-Barr virus (EBV) and is critical for EBV-induced B-cell transformation in vitro…”
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Author Correction: DNA methylation entropy as a measure of stem cell replication and aging by Vaidya, Himani, Jeong, Hye Seon, Keith, Kelsey, Maegawa, Shinji, Calendo, Gennaro, Madzo, Jozef, Jelinek, Jaroslav, Issa, Jean-Pierre J

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TET1-Mediated Hydroxymethylation Facilitates Hypoxic Gene Induction in Neuroblastoma by Mariani, Christopher J., Vasanthakumar, Aparna, Madzo, Jozef, Yesilkanal, Ali, Bhagat, Tushar, Yu, Yiting, Bhattacharyya, Sanchari, Wenger, Roland H., Cohn, Susan L., Nanduri, Jayasri, Verma, Amit, Prabhakar, Nanduri R., Godley, Lucy A.

“…The ten-eleven-translocation 5-methylcytosine dioxygenase (TET) family of enzymes catalyzes the conversion of 5-methylcytosine (5-mC) to…”
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The nuclear lamina binds the EBV genome during latency and regulates viral gene expression by Caruso, Lisa Beatrice, Guo, Rui, Keith, Kelsey, Madzo, Jozef, Maestri, Davide, Boyle, Sarah, Wasserman, Jason, Kossenkov, Andrew, Gewurz, Benjamin E, Tempera, Italo

“…The Epstein Barr virus (EBV) infects almost 95% of the population worldwide. While typically asymptomatic, EBV latent infection is associated with several…”
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TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor-Binding Sites in Chronic Myelomonocytic Leukemia by Yamazaki, Jumpei, Jelinek, Jaroslav, Lu, Yue, Cesaroni, Matteo, Madzo, Jozef, Neumann, Frank, He, Rong, Taby, Rodolphe, Vasanthakumar, Aparna, Macrae, Trisha, Ostler, Kelly R, Kantarjian, Hagop M, Liang, Shoudan, Estecio, Marcos R, Godley, Lucy A, Issa, Jean-Pierre J

“…TET2 enzymatically converts 5-methylcytosine to 5-hydroxymethylcytosine as well as other covalently modified cytosines and its mutations are common in myeloid…”
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Accelerated aging in normal breast tissue of women with breast cancer by Panjarian, Shoghag, Madzo, Jozef, Keith, Kelsey, Slater, Carolyn M, Sapienza, Carmen, Jelinek, Jaroslav, Issa, Jean-Pierre J

“…DNA methylation alterations have similar patterns in normal aging tissue and in cancer. In this study, we investigated breast tissue-specific age-related DNA…”
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ursaPGx: a new R package to annotate pharmacogenetic star alleles using phased whole-genome sequencing data by Calendo, Gennaro, Kusic, Dara, Madzo, Jozef, Gharani, Neda, Scheinfeldt, Laura

“…Long-read sequencing technologies offer new opportunities to generate high-confidence phased whole-genome sequencing data for robust pharmacogenetic…”
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Non-pathogenic microbiota accelerate age-related CpG Island methylation in colonic mucosa by Sun, Ang, Park, Pyounghwa, Cole, Lauren, Vaidya, Himani, Maegawa, Shinji, Keith, Kelsey, Calendo, Gennaro, Madzo, Jozef, Jelinek, Jaroslav, Jobin, Christian, Issa, Jean-Pierre J.

“…DNA methylation is an epigenetic process altered in cancer and ageing. Age-related methylation drift can be used to estimate lifespan and can be influenced by…”
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Decitabine disrupts EBV genomic epiallele DNA methylation patterns around CTCF binding sites to increase chromatin accessibility and lytic transcription in gastric cancer by Preston-Alp, Sarah, Caruso, Lisa Beatrice, Su, Chenhe, Keith, Kelsey, Soldan, Samantha S, Maestri, Davide, Madzo, Jozef, Kossenkov, Andrew, Napoletani, Giorgia, Gewurz, Benjamin, Lieberman, Paul M, Tempera, Italo

“…Epstein-Barr virus (EBV) latency is controlled by epigenetic silencing by DNA methylation [5-methyl cytosine (5mC)], histone modifications, and chromatin…”
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The developmental origins of sex-biased expression in cardiac development by Deegan, Daniel F, Karbalaei, Reza, Madzo, Jozef, Kulathinal, Rob J, Engel, Nora

“…Expression patterns between males and females vary in every adult tissue, even in organs with no conspicuous dimorphisms such as the heart. While studies of…”
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Postmortem toxicology findings from the Camden Opioid Research Initiative by Kusic, Dara M, Heil, Jessica, Zajic, Stefan, Brangan, Andrew, Dairo, Oluseun, Heil, Stacey, Feigin, Gerald, Kacinko, Sherri, Buono, Russell J, Ferraro, Thomas N, Rafeq, Rachel, Haroz, Rachel, Baston, Kaitlan, Bodofsky, Elliot, Sabia, Michael, Salzman, Matthew, Resch, Alissa, Madzo, Jozef, Scheinfeldt, Laura B, Issa, Jean-Pierre J, Jelinek, Jaroslav

“…The United States continues to be impacted by decades of an opioid misuse epidemic, worsened by the COVID-19 pandemic and by the growing prevalence of highly…”
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TET-catalyzed 5-hydroxymethylcytosine regulates gene expression in differentiating colonocytes and colon cancer by Chapman, Christopher G., Mariani, Christopher J., Wu, Feng, Meckel, Katherine, Butun, Fatma, Chuang, Alice, Madzo, Jozef, Bissonnette, Marc B., Kwon, John H., Godley, Lucy A.

“…The formation of differentiated cell types from pluripotent progenitors involves epigenetic regulation of gene expression. DNA hydroxymethylation results from…”
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