Search Results - "Mady, Ahmed S"

Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl‑1 and Bfl‑1 Proteins by Kump, Karson J, Miao, Lei, Mady, Ahmed S. A, Ansari, Nurul H, Shrestha, Uttar K, Yang, Yuting, Pal, Mohan, Liao, Chenzhong, Perdih, Andrej, Abulwerdi, Fardokht A, Chinnaswamy, Krishnapriya, Meagher, Jennifer L, Carlson, Jacob M, Khanna, May, Stuckey, Jeanne A, Nikolovska-Coleska, Zaneta

“…Anti-apoptotic Bcl-2 family proteins are overexpressed in a wide spectrum of cancers and have become well validated therapeutic targets. Cancer cells display…”
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Recent developments in bisintercalator natural products by Zolova, Olga E., Mady, Ahmed S. A., Garneau-Tsodikova, Sylvie

“…The bisintercalator natural products are a family of nonribosomal peptides possessing a range of biological properties that include antiviral, antibiotic, and…”
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PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity by Gozgit, Joseph M., Vasbinder, Melissa M., Abo, Ryan P., Kunii, Kaiko, Kuplast-Barr, Kristy G., Gui, Bin, Lu, Alvin Z., Molina, Jennifer R., Minissale, Elena, Swinger, Kerren K., Wigle, Tim J., Blackwell, Danielle J., Majer, Christina R., Ren, Yue, Niepel, Mario, Varsamis, Zacharenia A., Nayak, Sunaina P., Bamberg, Ellen, Mo, Jan-Rung, Church, W. David, Mady, Ahmed S.A., Song, Jeff, Utley, Luke, Rao, Patricia E., Mitchison, Timothy J., Kuntz, Kevin W., Richon, Victoria M., Keilhack, Heike

“…PARP7 is a monoPARP that catalyzes the transfer of single units of ADP-ribose onto substrates to change their function. Here, we identify PARP7 as a negative…”
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The WD40 domain of FBXW7 is a poly(ADP-ribose)-binding domain that mediates the early DNA damage response by Zhang, Qiang, Mady, Ahmed S A, Ma, Yuanyuan, Ryan, Caila, Lawrence, Theodore S, Nikolovska-Coleska, Zaneta, Sun, Yi, Morgan, Meredith A

“…Abstract FBXW7, a classic tumor suppressor, is a substrate recognition subunit of the Skp1-cullin-F-box (SCF) ubiquitin ligase that targets oncoproteins for…”
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A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo by Abulwerdi, Fardokht, Liao, Chenzhong, Liu, Meilan, Azmi, Asfar S, Aboukameel, Amro, Mady, Ahmed S A, Gulappa, Thippeswamy, Cierpicki, Tomasz, Owens, Scott, Zhang, Tao, Sun, Duxin, Stuckey, Jeanne A, Mohammad, Ramzi M, Nikolovska-Coleska, Zaneta

“…Using a high-throughput screening (HTS) approach, we have identified and validated several small-molecule Mcl-1 inhibitors (SMI). Here, we describe a novel…”
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3‑Substituted‑N‑(4-Hydroxynaphthalen-1-yl)arylsulfonamides as a Novel Class of Selective Mcl‑1 Inhibitors: Structure-Based Design, Synthesis, SAR, and Biological Evaluation by Abulwerdi, Fardokht A, Liao, Chenzhong, Mady, Ahmed S, Gavin, Jordan, Shen, Chenxi, Cierpicki, Tomasz, Stuckey, Jeanne A, Showalter, H. D. Hollis, Nikolovska-Coleska, Zaneta

“…Mcl-1, an antiapoptotic member of the Bcl-2 family of proteins, is a validated and attractive target for cancer therapy. Overexpression of Mcl-1 in many…”
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Wnt/β-catenin signaling directs the regional expansion of first and second heart field-derived ventricular cardiomyocytes by Buikema, Jan Willem, Mady, Ahmed S, Mittal, Nikhil V, Atmanli, Ayhan, Caron, Leslie, Doevendans, Pieter A, Sluijter, Joost P G, Domian, Ibrahim J

“…In mammals, cardiac development proceeds from the formation of the linear heart tube, through complex looping and septation, all the while increasing in mass…”
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Discovery of Mcl-1 inhibitors from integrated high throughput and virtual screening by Mady, Ahmed S. A., Liao, Chenzhong, Bajwa, Naval, Kump, Karson J., Abulwerdi, Fardokht A., Lev, Katherine L., Miao, Lei, Grigsby, Sierrah M., Perdih, Andrej, Stuckey, Jeanne A., Du, Yuhong, Fu, Haian, Nikolovska-Coleska, Zaneta

“…Protein-protein interactions (PPIs) represent important and promising therapeutic targets that are associated with the regulation of various molecular…”
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Directed Modulation of Protein Kinase C Isozyme Selectivity with Bisubstrate-Based Inhibitors by van Wandelen, Loek T. M., van Ameijde, Jeroen, Mady, Ahmed S. A., Wammes, Angelique E. M., Bode, Alois, Poot, Alex J., Ruijtenbeek, Rob, Liskamp, Rob M. J.

“…Kinases present an attractive target for drug development, since they are involved in vital cellular processes and are implicated in a variety of diseases,…”
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Characterization of TioQ, a type II thioesterase from the thiocoraline biosynthetic cluster by Mady, Ahmed S A, Zolova, Olga E, Millán, María Álvarez San, Villamizar, Germán, de la Calle, Fernando, Lombó, Felipe, Garneau-Tsodikova, Sylvie

“…An antitumor agent thiocoraline is a thiodepsipeptide marine product derived from two Micromonospora sp. strains that inhibits protein synthesis by binding of…”
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The deacylase SIRT5 supports melanoma viability by influencing chromatin dynamics by Giblin, William, Bringman-Rodenbarger, Lauren, Guo, Angela H, Kumar, Surinder, Monovich, Alexander C, Mostafa, Ahmed M, Skinner, Mary E, Azar, Michelle, Mady, Ahmed Sa, Chung, Carolina H, Kadambi, Namrata, Melong, Keith-Allen, Lee, Ho-Joon, Zhang, Li, Sajjakulnukit, Peter, Trefely, Sophie, Varner, Erika L, Iyer, Sowmya, Wang, Min, Wilmott, James S, Soyer, H Peter, Sturm, Richard A, Pritchard, Antonia L, Andea, Aleodor A, Scolyer, Richard A, Stark, Mitchell S, Scott, David A, Fullen, Douglas R, Bosenberg, Marcus W, Chandrasekaran, Sriram, Nikolovska-Coleska, Zaneta, Verhaegen, Monique E, Snyder, Nathaniel W, Rivera, Miguel N, Osterman, Andrei L, Lyssiotis, Costas A, Lombard, David B

“…Cutaneous melanoma remains the most lethal skin cancer, and ranks third among all malignancies in terms of years of life lost. Despite the advent of immune…”
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Abstract 1970: Novel Mcl-1 inhibitor effectively restores in vivo regorafenib sensitivity in resistant colorectal cancer by Kump, Karson J., Tong, Jingshan, Mady, Ahmed S., Miao, Lei, Li, Siwei, Sun, Duxin, Yu, Jian, Zhang, Lin, Nikolovska-Coleska, Zaneta

“…Abstract Colorectal cancer (CRC) is one of deadliest malignancies and approximately 25% of patients present with metastatic disease at the time of diagnosis,…”
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Abstract 1173: A novel selective Mcl-1 inhibitor exhibits in vitro and in vivo efficacy in melanoma by Kump, Karson J., Miao, Lei, Mady, Ahmed S., Lev, Katherine, Giblin, William, Skinner, Mary E., Lombard, David B., Nikolovska-Coleska, Zaneta

“…Abstract Metastatic melanoma is the deadliest form of skin cancer that still has limited treatment options and dismal 5-year year survival rates as low as 15%…”
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Abstract 2154: PARP7 inhibitor RBN-2397 increases tumoral IFN signaling leading to various tumor cell intrinsic effects and tumor regressions in mouse models by Molina, Jennifer R., Gozgit, Joseph M., Vasbinder, Melissa M., Abo, Ryan P., kunii, Kaiko, Kuplast-Barr, Kristy G., Gui, Bin, Nayak, Sunaina P., Minissale, Elena, Swinger, Kerren K., Wigle, Tim J., Lu, Alvin Z., Blackwell, Danielle J., Majer, Christina R., Ren, Yue, Bamberg, Ellen, Niepel, Mario, Mo, Jan-Rung, Church, William D., Mady, Ahmed S., Song, Jeff, Varsamis, Zacharenia A., Utley, Luke, Rao, Patricia E., Mitchison, Timoty J., Kuntz, Kevin W., Richon, Victoria M., McEachern, Kristen, Keilhack, Heike

“…Abstract Targeting cytosolic nucleic acid sensing pathways to activate the Type I interferon (IFN) response is an emerging therapeutic strategy being explored…”
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Directed Modulation of Protein KinaseC Isozyme Selectivity with Bisubstrate-Based Inhibitors by vanWandelen, Loek T. M, vanAmeijde, Jeroen, Mady, Ahmed S. A, Wammes, Angelique E. M, Bode, Alois, Poot, Alex J, Ruijtenbeek, Rob, Liskamp, Rob M. J

“…Kinases present an attractive target for drug development, since they are involved in vital cellular processes and are implicated in a variety of diseases,…”
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Inside Cover: Directed Modulation of Protein Kinase C Isozyme Selectivity with Bisubstrate-Based Inhibitors (ChemMedChem 12/2012) by van Wandelen, Loek T. M., van Ameijde, Jeroen, Mady, Ahmed S. A., Wammes, Angelique E. M., Bode, Alois, Poot, Alex J., Ruijtenbeek, Rob, Liskamp, Rob M. J.

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Inside Cover: Directed Modulation of Protein KinaseC Isozyme Selectivity with Bisubstrate-Based Inhibitors (ChemMedChem 12/2012) by vanWandelen, Loek T. M, vanAmeijde, Jeroen, Mady, Ahmed S. A, Wammes, Angelique E. M, Bode, Alois, Poot, Alex J, Ruijtenbeek, Rob, Liskamp, Rob M. J

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