Search Results - "Madura, Florian"

Dual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope by Cole, David K, Fuller, Anna, Dolton, Garry, Zervoudi, Efthalia, Legut, Mateusz, Miles, Kim, Blanchfield, Lori, Madura, Florian, Holland, Christopher J, Bulek, Anna M, Bridgeman, John S, Miles, John J, Schauenburg, Andrea J A, Beck, Konrad, Evavold, Brian D, Rizkallah, Pierre J, Sewell, Andrew K

“…Serial accumulation of mutations to fixation in the SLYNTVATL (SL9) immunodominant, HIV p17 Gag-derived, HLA A2-restricted cytotoxic T lymphocyte epitope…”
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Molecular Rules Underpinning Enhanced Affinity Binding of Human T Cell Receptors Engineered for Immunotherapy by Crean, Rory M., MacLachlan, Bruce J., Madura, Florian, Whalley, Thomas, Rizkallah, Pierre J., Holland, Christopher J., McMurran, Catriona, Harper, Stephen, Godkin, Andrew, Sewell, Andrew K., Pudney, Christopher R., van der Kamp, Marc W., Cole, David K.

“…Immuno-oncology approaches that utilize T cell receptors (TCRs) are becoming highly attractive because of their potential to target virtually all cellular…”
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Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes by Bulek, Anna M, Cole, David K, Skowera, Ania, Dolton, Garry, Gras, Stephanie, Madura, Florian, Fuller, Anna, Miles, John J, Gostick, Emma, Price, David A, Drijfhout, Jan W, Knight, Robin R, Huang, Guo C, Lissin, Nikolai, Molloy, Peter E, Wooldridge, Linda, Jakobsen, Bent K, Rossjohn, Jamie, Peakman, Mark, Rizkallah, Pierre J, Sewell, Andrew K

“…Much is known about crystal structures of MHC class II–autoreactive TCRs. Sewell and colleagues provide the structure of an MHC class I–autoreactive TCR and…”
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TCR‐induced alteration of primary MHC peptide anchor residue by Madura, Florian, Rizkallah, Pierre J., Legut, Mateusz, Holland, Christopher J., Fuller, Anna, Bulek, Anna, Schauenburg, Andrea J., Trimby, Andrew, Hopkins, Jade R., Wells, Stephen A., Godkin, Andrew, Miles, John J., Sami, Malkit, Li, Yi, Liddy, Nathaniel, Jakobsen, Bent K., Loveridge, E. Joel, Cole, David K., Sewell, Andrew K.

“…The HLA‐A*02:01‐restricted decapeptide EAAGIGILTV, derived from melanoma antigen recognized by T‐cells‐1 (MART‐1) protein, represents one of the best‐studied…”
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Structural basis for ineffective T‐cell responses to MHC anchor residue‐improved “heteroclitic” peptides by Madura, Florian, Rizkallah, Pierre J., Holland, Christopher J., Fuller, Anna, Bulek, Anna, Godkin, Andrew J., Schauenburg, Andrea J., Cole, David K., Sewell, Andrew K.

“…MHC anchor residue‐modified “heteroclitic” peptides have been used in many cancer vaccine trials and often induce greater immune responses than the wild‐type…”
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T-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex Interactions by Cole, David K., Miles, Kim M., Madura, Florian, Holland, Christopher J., Schauenburg, Andrea J.A., Godkin, Andrew J., Bulek, Anna M., Fuller, Anna, Akpovwa, Hephzibah J.E., Pymm, Phillip G., Liddy, Nathaniel, Sami, Malkit, Li, Yi, Rizkallah, Pierre J., Jakobsen, Bent K., Sewell, Andrew K.

“…αβ T-cell receptors (TCRs) engage antigens using complementarity-determining region (CDR) loops that are either germ line-encoded (CDR1 and CDR2) or…”
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T-cell Receptor Specificity Maintained by Altered Thermodynamics by Madura, Florian, Rizkallah, Pierre J., Miles, Kim M., Holland, Christopher J., Bulek, Anna M., Fuller, Anna, Schauenburg, Andrea J.A., Miles, John J., Liddy, Nathaniel, Sami, Malkit, Li, Yi, Hossain, Moushumi, Baker, Brian M., Jakobsen, Bent K., Sewell, Andrew K., Cole, David K.

“…The T-cell receptor (TCR) recognizes peptides bound to major histocompatibility molecules (MHC) and allows T-cells to interrogate the cellular proteome for…”
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Enhanced Detection of Antigen-Specific CD4+ T Cells Using Altered Peptide Flanking Residue Peptide-MHC Class II Multimers by Holland, Christopher J, Dolton, Garry, Scurr, Martin, Ladell, Kristin, Schauenburg, Andrea J, Miners, Kelly, Madura, Florian, Sewell, Andrew K, Price, David A, Cole, David K, Godkin, Andrew J

“…Fluorochrome-conjugated peptide-MHC (pMHC) class I multimers are staple components of the immunologist's toolbox, enabling reliable quantification and analysis…”
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T-cell Receptor-optimized Peptide Skewing of the T-cell Repertoire Can Enhance Antigen Targeting by Ekeruche-Makinde, Julia, Clement, Mathew, Cole, David K., Edwards, Emily S.J., Ladell, Kristin, Miles, John J., Matthews, Katherine K., Fuller, Anna, Lloyd, Katy A., Madura, Florian, Dolton, Garry M., Pentier, Johanne, Lissina, Anna, Gostick, Emma, Baxter, Tiffany K., Baker, Brian M., Rizkallah, Pierre J., Price, David A., Wooldridge, Linda, Sewell, Andrew K.

“…Altered peptide antigens that enhance T-cell immunogenicity have been used to improve peptide-based vaccination for a range of diseases. Although this strategy…”
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Real time detection of peptide–MHC dissociation reveals that improvement of primary MHC-binding residues can have a minimal, or no, effect on stability by Miles, Kim M., Miles, John J., Madura, Florian, Sewell, Andrew K., Cole, David K.

“…The majority of known major histocompatibility complex class I (MHCI)-associated tumor-derived peptide antigens do not contain an optimal motif for MHCI…”
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TCR/pMHC Optimized Protein crystallization Screen by Bulek, Anna M., Madura, Florian, Fuller, Anna, Holland, Christopher J., Schauenburg, Andrea J.A., Sewell, Andrew K., Rizkallah, Pierre J., Cole, David K.

“…The interaction between the clonotypic αβ T cell receptor (TCR), expressed on the T cell surface, and peptide-major histocompatibility complex (pMHC)…”
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Minimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimers by Holland, Christopher J., Rizkallah, Pierre J., Vollers, Sabrina, Calvo-Calle, J. Mauricio, Madura, Florian, Fuller, Anna, Sewell, Andrew K., Stern, Lawrence J., Godkin, Andrew, Cole, David K.

“…Successful immunity requires that a limited pool of αβ T-cell receptors (TCRs) provide cover for a vast number of potential foreign peptide antigens presented…”
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Structural and biophysical insights from targeting melanoma using genetically modified t-cell receptors by Madura, Florian

“…CD8+ T-cells recognise pathogens and cancer through a specific interaction between the T-cell receptor (TCR) and a 8-14 amino-acid residue peptide presented by…”
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T-cell Receptor Specificity Maintained by Altered Thermodynamics<inline-graphic xlink:href="sbox.jpg"/> by Madura, Florian, Rizkallah, Pierre J, Miles, Kim M, Holland, Christopher J, Bulek, Anna M, Fuller, Anna, Schauenburg, Andrea JA, Miles, John J, Liddy, Nathaniel, Sami, Malkit, Li, Yi, Hossain, Moushumi, Baker, Brian M, Jakobsen, Bent K, Sewell, Andrew K, Cole, David K

“…Background: The molecular principles governing T-cell specificity are poorly understood. Results: High affinity binding of a melanoma-specific T-cell receptor…”
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Structural basis for the killing of human beta cells by [CD8.sup.+] T cells in type 1 diabetes by Bulek, Anna M, Cole, David K, Skowera, Ania, Dolton, Garry, Gras, Stephanie, Madura, Florian, Fuller, Anna, Miles, John J, Gostick, Emma, Price, David A, Drijfhout, Jan W, Knight, Robin R, Huang, Guo C, Lissin, Nikolai, Molloy, Peter E, Wooldridge, Linda, Jakobsen, Bent K, Rossjohn, Jamie, Peakman, Mark, Rizkallah, Pierre J, Sewell, Andrew K

“…The structural characteristics of the engagement of major histocompatibility complex (MHC) class II-restricted self antigens by autoreactive T cell antigen…”
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Structural basis for the killing of human beta cells by CD8 super(+) T cells in type 1 diabetes by Bulek, Anna M, Cole, David K, Skowera, Ania, Dolton, Garry, Gras, Stephanie, Madura, Florian, Fuller, Anna, Miles, John J, Gostick, Emma, Price, David A, Drijfhout, Jan W, Knight, Robin R, Huang, Guo C, Lissin, Nikolai, Molloy, Peter E, Wooldridge, Linda, Jakobsen, Bent K, Rossjohn, Jamie, Peakman, Mark, Rizkallah, Pierre J, Sewell, Andrew K

“…The structural characteristics of the engagement of major histocompatibility complex (MHC) class II-restricted self antigens by autoreactive T cell antigen…”
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Structural basis of human β-cell killing by CD8+ T cells in Type 1 diabetes by Bulek, Anna M., Cole, David K., Skowera, Ania, Dolton, Garry, Gras, Stephanie, Madura, Florian, Fuller, Anna, Miles, John J., Gostick, Emma, Price, David A., Drijfhout, Jan W., Knight, Robin R., Huang, Guo C., Lissin, Nikolai, Molloy, Peter E., Wooldridge, Linda, Jakobsen, Bent K., Rossjohn, Jamie, Peakman, Mark, Rizkallah, Pierre J., Sewell, Andrew K.

“…The structural characteristics of autoreactive-T cell receptor (TCR) engagement of major histocompatability (MHC) class II-restricted self-antigens is…”
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