Search Results - "Madu, Ikenna G."

Characterization of a Highly Conserved Domain within the Severe Acute Respiratory Syndrome Coronavirus Spike Protein S2 Domain with Characteristics of a Viral Fusion Peptide by MADU, Ikenna G, ROTH, Shoshannah L, BELOUZARD, Sandrine, WHITTAKER, Gary R

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Lassa antiviral LHF-535 protects guinea pigs from lethal challenge by Cashman, Kathleen A., Wilkinson, Eric R., Posakony, Jeffrey, Madu, Ikenna G., Tarcha, Eric J., Lustig, Kurt H., Korth, Marcus J., Bedard, Kristin M., Amberg, Sean M.

“…LHF-535 is a small molecule antiviral currently in development for the treatment of Lassa fever, a zoonotic disease endemic in West Africa that generates…”
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A potent Lassa virus antiviral targets an arenavirus virulence determinant by Madu, Ikenna G, Files, Megan, Gharaibeh, Dima N, Moore, Amy L, Jung, Kie-Hoon, Gowen, Brian B, Dai, Dongcheng, Jones, Kevin F, Tyavanagimatt, Shanthakumar R, Burgeson, James R, Korth, Marcus J, Bedard, Kristin M, Iadonato, Shawn P, Amberg, Sean M

“…Arenaviruses are a significant cause of hemorrhagic fever, an often-fatal disease for which there is no approved antiviral therapy. Lassa fever in particular…”
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Identification and Characterization of a New Chemotype of Noncovalent SENP Inhibitors by Madu, Ikenna G, Namanja, Andrew T, Su, Yang, Wong, Steven, Li, Yi-Jia, Chen, Yuan

“…Enzymes called SENPs catalyze both the maturation of small ubiquitin-like modifier (SUMO) precursors and removal of SUMO modifications, which regulate…”
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Heparan Sulfate Is a Selective Attachment Factor for the Avian Coronavirus Infectious Bronchitis Virus Beaudette by Madu, Ikenna G, Chu, Victor C, Lee, Hwajin, Regan, Andrew D, Bauman, Beverley E, Whittaker, Gary R

“…The avian coronavirus infectious bronchitis virus (IBV) strain Beaudette is an embryo-adapted virus that has extended species tropism in cell culture. In order…”
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A Novel Class of HIV-1 Antiviral Agents Targeting HIV via a SUMOylation-Dependent Mechanism by Madu, Ikenna G., Li, Shirley, Li, Baozong, Li, Haitang, Chang, Tammy, Li, Yi-Jia, Vega, Ramir, Rossi, John, Yee, Jiing-Kuan, Zaia, John, Chen, Yuan

“…We have recently identified a chemotype of small ubiquitin-like modifier (SUMO)-specific protease (SENP) inhibitors. Prior to the discovery of their SENP…”
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SARS-coronavirus spike S2 domain flanked by cysteine residues C822 and C833 is important for activation of membrane fusion by Madu, Ikenna G, Belouzard, Sandrine, Whittaker, Gary R

“…Abstract The S2 domain of the coronavirus spike (S) protein is known to be responsible for mediating membrane fusion. In addition to a well-recognized cleavage…”
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Assays for investigating deSUMOylation enzymes by Madu, Ikenna G, Chen, Yuan

“…Post-translational modifications by the SUMO (Small Ubiquitin-like MOdifier) family of proteins are recently discovered essential regulatory mechanisms. All…”
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IDENTIFICATION AND CHARACTERIZATION OF A NEW CHEMOTYPE OF NON-COVALENT SENP INHIBITORS by Madu, Ikenna G., Namanja, Andrew T., Su, Yang, Wong, Steven, Li, Yi-Jia, Chen, Yuan

“…Enzymes called SENPs catalyze both the maturation of small ubiquitin-like modifier (SUMO) precursors and removal of SUMO modifications, which regulate…”
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