Search Results - "Madsen, U."

Ligands for Glutamate Receptors:  Design and Therapeutic Prospects by Bräuner-Osborne, Hans, Egebjerg, Jan, Nielsen, Elsebet Ø, Madsen, Ulf, Krogsgaard-Larsen, Povl

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Inhibitors of AMPA and kainate receptors by Madsen, U, Stensbøl, T B, Krogsgaard-Larsen, P

“…The glutamate receptor system is implicated in the development and maintenance of epileptic seizures, and animal studies have disclosed potent anticonvulsant…”
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Novel 1-Hydroxyazole Bioisosteres of Glutamic Acid. Synthesis, Protolytic Properties, and Pharmacology by Stensbøl, Tine B, Uhlmann, Peter, Morel, Sandrine, Eriksen, Birgitte L, Felding, Jakob, Kromann, Hasse, Hermit, Mette B, Greenwood, Jeremy R, Braüner-Osborne, Hans, Madsen, Ulf, Junager, Finn, Krogsgaard-Larsen, Povl, Begtrup, Mikael, Vedsø, Per

“…A number of 1-hydroxyazole derivatives were synthesized as bioisosteres of (S)-glutamic acid (Glu) and as analogues of the AMPA receptor agonist…”
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Resolution, absolute stereochemistry and molecular pharmacology of the enantiomers of ATPA by Stensbøl, Tine B, Borre, Lars, Johansen, Tommy N, Egebjerg, Jan, Madsen, Ulf, Ebert, Bjarke, Krogsgaard-Larsen, Povl

“…( RS)-2-Amino-3-(5- tert-butyl-3-hydroxy-4-isoxazolyl)propionic acid (ATPA), an analogue of ( RS)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid…”
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Structural Determinants of AMPA Agonist Activity in Analogues of 2-Amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic Acid:  Synthesis and Pharmacology by Bang-Andersen, Benny, Ahmadian, Haleh, Lenz, Sibylle M, Stensbøl, Tine B, Madsen, Ulf, Bøgesø, Klaus P, Krogsgaard-Larsen, Povl

“…We have previously shown that the 2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor agonist,…”
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Agonist discrimination between AMPA receptor subtypes by Coquelle, Thomas, Christensen, Jeppe K, Banke, Tue G, Madsen, Ulf, Schousboe, Arne, Pickering, Darryl S

“…The lack of subtype-selective compounds for AMPA receptors (AMPA-R) led us to search for compounds with such selectivity. Homoibotenic acid analogues were…”
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(S)-Homo-AMPA, a Specific Agonist at the mGlu6 Subtype of Metabotropic Glutamic Acid Receptors by Ahmadian, Haleh, Nielsen, Birgitte, Bräuner-Osborne, Hans, Johansen, Tommy N, Stensbøl, Tine B, Sløk, Frank A, Sekiyama, Naohiro, Nakanishi, Shigetada, Krogsgaard-Larsen, Povl, Madsen, Ulf

“…Our previous publication (J. Med. Chem. 1996, 39, 3188−3194) described (RS)-2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid (Homo-AMPA) as a highly…”
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Synthesis and Pharmacology of 3-Isoxazolol Amino Acids as Selective Antagonists at Group I Metabotropic Glutamic Acid Receptors by Madsen, Ulf, Bräuner-Osborne, Hans, Frydenvang, Karla, Hvene, Lise, Johansen, Tommy N, Nielsen, Birgitte, Sánchez, Connie, Stensbøl, Tine B, Bischoff, Francois, Krogsgaard-Larsen, Povl

“…Using ibotenic acid (2) as a lead, two series of 3-isoxazolol amino acid ligands for (S)-glutamic acid (Glu, 1) receptors have been developed. Whereas…”
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Pharmacology and toxicology of ATOA, an AMPA receptor antagonist and a partial agonist at GluR5 receptors by Wahl, P, Frandsen, A, Madsen, U, Schousboe, A, Krogsgaard-Larsen, P

“…( RS)-2-Amino-3-[3-(carboxymethoxy)-5- tert-butyl-4-isoxazolyl]propionic acid (ATOA) has previously been described as an antagonist at (…”
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Design of excitatory amino acid receptor agonists, partial agonists and antagonists: ibotenic acid as a key lead structure by Krogsgaard-Larsen, P, Ebert, B, Lund, TM, Bräuner-Osborne, H, Sløk, FA, Johansen, TN, Brehm, L, Madsen, U

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Excitatory amino-acid receptor agonists. Synthesis and pharmacology of analogues of 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid by Sløk, F.A., Ebert, B, Lang, Y, Krogsgaard-Larsen, P, Lenz, S.M., Madsen, U

“…We have previously proposed the existence of a lipophilic cavity of the 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptor recognition…”
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Synthesis and Pharmacology of a New AMPA−Kainate Receptor Agonist with Potent Convulsant Activity by Conti, Paola, De Amici, Marco, De Sarro, Giovambattista, Stensbøl, Tine Bryan, Bräuner-Osborne, Hans, Madsen, Ulf, De Micheli, Carlo

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Excitatory amino acid receptor ligands: Asymmetric synthesis, absolute stereochemistry and pharmacology of ( R)- and ( S)-homoibotenic acid by Bischoff, F., Johansen, T.N., Ebert, B., Krogsgaard-Larsen, P., Madsen, U.

“…The ( R)- and ( S)-forms of 2-amino-3-(3-hydroxyisoxazol-5-yl)propionic acid (homoibotenic acid, HIBO) were synthesized, using ( S)-BOC-phenylalanine as a…”
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Differentiation of in vivo effects of AMPA and NMDA receptor ligands using drug discrimination methods and convulsant/anticonvulsant activity by Arnt, Jørn, Sánchez, Connie, Lenz, Sibylle Moltzen, Madsen, Ulf, Krogsgaard-Larsen, Povl

“…The discriminative stimulus properties of the AMPA (( RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid) receptor agonist ATPA ((…”
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Modulation of AMPA receptor function in relation to glutamatergic abnormalities in Alzheimer's disease by Madsen, U, Ebert, B, Krogsgaard-Larsen, P

“…Abnormalities in the excitatory glutamate neurotransmitter system appear to be a prominent factor in Alzheimer's disease (AD). Whereas hypoactivity of this…”
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Studies of the antagonist actions of (RS)‐2‐amino‐3‐[5‐tert‐butyl‐3‐(phosphonomethoxy)‐4‐isoxazolyl]propionic acid (ATPO) on non‐NMDA receptors in cultured rat neurones by Dai, W‐M, Ebert, B, Madsen, U, Lambert, J D C

“…Whole‐cell patch‐clamp recordings from single cultured cortical neurones have been used to study the action of…”
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Synthesis and pharmacology of 3-hydroxy-delta2-isoxazoline-cyclopentane analogues of glutamic acid by Conti, P, De Amici, M, Bräuner-Osborne, H, Madsen, U, Toma, L, De Micheli, C

“…The synthesis and pharmacology of two potential glutamic acid receptor ligands are described. Preparation of the bicyclic…”
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Novel class of amino acid antagonists at non-N-methyl-D-aspartic acid excitatory amino acid receptors. Synthesis, in vitro and in vivo pharmacology, and neuroprotection by Krogsgaard-Larsen, Povl, Ferkany, John W, Nielsen, Elsebet O, Madsen, Ulf, Ebert, Bjarke, Johansen, Joergen S, Diemer, Nils H, Bruhn, Torben, Beattie, David T, Curtis, David R

“…The isoxazole amino acid 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl) propionic acid (AMPA) (1), which is a highly selective agonist at the AMPA subtype of…”
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Long-term results in patients with headaches related to nasal obstruction by Schønsted-Madsen, U

“…To determine if the results found at one year follow-up examinations after functional nasal surgery were valid, 70 patients suffering from both nasal…”
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Long-term results of functional and cosmetic rhinoplastic surgery by Schønsted-Madsen, U, Stoksted, P

“…Three hundred and twelve of 444 patients admitted consecutively for rhinosurgery for nasal obstruction have been examined 5 years postoperatively regarding…”
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