Search Results - "Madsen, O D"

Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation by JENSEN, J, HELLER, R. S, FUNDER-NIELSEN, T, PEDERSEN, E. E, LINDSELL, C, WEINMASTER, G, MADSEN, O. D, SERUP, P

“…Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature…”
Get full text

Pancreatic islet and progenitor cell surface markers with cell sorting potential by Hald, J., Galbo, T., Rescan, C., Radzikowski, L., Sprinkel, A. E., Heimberg, H., Ahnfelt-Rønne, J., Jensen, J., Scharfmann, R., Gradwohl, G., Kaestner, K. H., Stoeckert, C., Jensen, J. N., Madsen, O. D.

“…Aims/hypothesis The aim of the study was to identify surface bio-markers and corresponding antibody tools that can be used for the imaging and immunoisolation…”
Get full text

Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1 by Torekov, S. S., Ma, L., Grarup, N., Hartmann, B., Hainerová, I. A., Kielgast, U., Kissow, H., Rosenkilde, M., Lebl, J., Witte, D. R., Jørgensen, T., Sandbaek, A., Lauritzen, T., Madsen, O. D., Wang, J., Linneberg, A., Madsbad, S., Holst, J. J., Hansen, T., Pedersen, O.

“…Aims/hypothesis The glucagon gene ( GCG ) encodes several hormones important for energy metabolism: glucagon, oxyntomodulin and glucagon-like peptide (GLP)-1…”
Get full text

Hypothalamic CART is a new anorectic peptide regulated by leptin by Kristensen, Peter, Judge, Martin E, Thim, Lars, Ribel, Ulla, Christjansen, Kennet N, Wulff, Birgitte S, Clausen, Jes T, Jensen, Per B, Madsen, Ole D, Vrang, Niels, Larsen, Philip J, Hastrup, Sven

“…The mammalian hypothalamus strongly influences ingestive behaviour through several different signalling molecules and receptor systems. Here we show that CART…”
Get full text

The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells by AMMENDRUP, A, MAILLARD, A, NIELSEN, K, ANDERSEN, N. A, SERUP, P, MADSEN, O. D, MANDRUP-POULSEN, T, BONNY, C

“…The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells. A…”
Get full text

Novel monoclonal antibodies against Pdx1 reveal feedback regulation of Pdx1 protein levels by Galbo, T, Pedersen, I L, Fløyel, T, Bang-Berthelsen, C H, Serup, P, Madsen, O D, Hald, J

“…The aim of this study was to characterize two monoclonal antibodies (F6A11 and F109-D12) generated against Pdx1 (pancreatic and duodenal homeobox-1), a…”
Get full text

Beta-cell maturation leads to in vitro sensitivity to cytotoxins by NIELSEN, K, KARLSEN, A. E, DECKERT, M, MADSEN, O. D, SERUP, P, MANDRUP-POULSEN, T, NERUP, J

“…Beta-cell maturation leads to in vitro sensitivity to cytotoxins. K Nielsen , A E Karlsen , M Deckert , O D Madsen , P Serup , T Mandrup-Poulsen and J Nerup…”
Get full text

Neurogenin 3+ cells contribute to β-cell neogenesis and proliferation in injured adult mouse pancreas by Van de Casteele, M, Leuckx, G, Baeyens, L, Cai, Y, Yuchi, Y, Coppens, V, De Groef, S, Eriksson, M, Svensson, C, Ahlgren, U, Ahnfelt-Rønne, J, Madsen, O D, Waisman, A, Dor, Y, Jensen, J N, Heimberg, H

“…We previously showed that injury by partial duct ligation (PDL) in adult mouse pancreas activates Neurogenin 3 (Ngn3) + progenitor cells that can differentiate…”
Get full text

Control of endodermal endocrine development by Hes-1 by Pedersen, Erna Engholm, Hald, Jacob, Serup, Palle, Galante, Philip, Jensen, Jan, Guillemot, Francois, Kageyama, Ryoichiro, Madsen, Ole D, Heller, R. Scott, Ishibashi, Makoto

“…Development of endocrine cells in the endoderm involves Atonal and Achaete/Scute-related basic helix-loop-helix (bHLH) proteins. These proteins also serve as…”
Get full text

Transcriptional Regulation of the Human Insulin Gene is Dependent on the Homeodomain Protein STF1/IPF1 Acting Through the CT Boxes by Petersen, Helle V., Serup, Palle, Leonard, James, Michelsen, Birgitte K., Madsen, Ole D.

“…Insulin gene transcription is a unique feature of the pancreatic β cells and is increased in response to glucose. The recent cloning of insulin promoter factor…”
Get full text

Revisiting the immunocytochemical detection of Neurogenin 3 expression in mouse and man by Honoré, C., Rescan, C., Hald, J., McGrath, P. S., Petersen, M. B. K., Hansson, M., Klein, T., Østergaard, S., Wells, J. M., Madsen, O. D.

“…During embryonic development, endocrine cells of the pancreas are specified from multipotent progenitors. The transcription factor Neurogenin 3 (NEUROG3) is…”
Get full text

The homeodomain protein IPF-1/STF-1 is expressed in a subset of islet cells and promotes rat insulin 1 gene expression dependent on an intact E1 helix-loop-helix factor binding site by Serup, P, Petersen, H V, Pedersen, E E, Edlund, H, Leonard, J, Petersen, J S, Larsson, L I, Madsen, O D

“…The mouse homeodomain protein insulin promoter factor-1 (IPF-1) and the rat homologue somatostatin transactivating factor-1 (STF-1) are involved in early…”
Get full text

Induction of Insulin and Islet Amyloid Polypeptide Production in Pancreatic Islet Glucagonoma Cells by Insulin Promoter Factor 1 by Serup, Palle, Jensen, Jan, Andersen, Frank G., Jørgensen, Mette C., Blume, Niels, Holst, Jens J., Madsen, Ole D.

“…Insulin promoter factor 1 (IPF1), a member of the homeodomain protein family, serves an early role in pancreas formation, as evidenced by the lack of pancreas…”
Get full text

Transcription factors contributing to the pancreatic beta-cell phenotype by Madsen, O D, Jensen, J, Petersen, H V, Pedersen, E E, Oster, A, Andersen, F G, Jørgensen, M C, Jensen, P B, Larsson, L I, Serup, P

“…Insulin promoter factor-1 (IPF1) (renamed to pancreatic-duodenal homeobox factor-1, PDX1) was originally cloned and characterized as an islet beta-cell…”
Get more information

Cloning, Characterization, and Autoimmune Recognition of Rat Islet Glutamic Acid Decarboxylase in Insulin-Dependent Diabetes Mellitus by Michelsen, Birgitte Koch, Petersen, Jacob Sten, Boel, Esper, Moldrup, Annette, Dyrberg, Thomas, Madsen, Ole Dragsbaek

“…A 64-kDa islet protein is a major autoantigen in insulin-dependent diabetes mellitus (IDDM). Autoantibodies against the 64-kDa protein were recently shown to…”
Get full text

Studies on the isolation, structural analysis and tissue localization of fetal antigen 1 and its relation to a human adrenal-specific cDNA, pG2 by Jensen, C H, Teisner, B, Højrup, P, Rasmussen, H B, Madsen, O D, Nielsen, B, Skjødt, K

“…Fetal antigen 1 was purified from second trimester human amniotic fluid by immunospecific affinity chromatography followed by reversed-phase chromatography…”
Get more information

A new view of the beta cell by Ahnfelt-Rønne, J., Hecksher-Sørensen, J., Schäffer, L., Madsen, O. D.

Get full text

Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development by Hald, Jacob, Hjorth, J.Peter, German, Michael S, Madsen, Ole D, Serup, Palle, Jensen, Jan

“…Mice carrying loss-of-function mutations in certain Notch pathway genes display increased and accelerated pancreatic endocrine development, leading to…”
Get full text

Foetal proglucagon processing in relation to adult appetite control: lessons from a transplantable rat glucagonoma with severe anorexia by Jensen, P. B., Larsen, P. J., Karlsen, C., Jensen, H. I., Holst, J. J., Madsen, O. D.

“…We have previously reported severe anorexia abruptly induced in rats 2–3 weeks after they have been transplanted subcutaneously with the glucagonoma MSL‐G‐AN…”
Get full text

Transplantable rat glucagonomas cause acute onset of severe anorexia and adipsia despite highly elevated NPY mRNA levels in the hypothalamic arcuate nucleus by Jensen, P B, Blume, N, Mikkelsen, J D, Larsen, P J, Jensen, H I, Holst, J J, Madsen, O D

“…We have isolated a stable, transplantable, and small glucagonoma (MSL-G-AN) associated with abrupt onset of severe anorexia occurring 2-3 wk after subcutaneous…”
Get full text