Search Results - "Madsen, Chris D"

Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing by Bartoschek, Michael, Oskolkov, Nikolay, Bocci, Matteo, Lövrot, John, Larsson, Christer, Sommarin, Mikael, Madsen, Chris D., Lindgren, David, Pekar, Gyula, Karlsson, Göran, Ringnér, Markus, Bergh, Jonas, Björklund, Åsa, Pietras, Kristian

“…Cancer-associated fibroblasts (CAFs) are a major constituent of the tumor microenvironment, although their origin and roles in shaping disease initiation,…”
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Cancer Dissemination—Lessons from Leukocytes by Madsen, Chris D., Sahai, Erik

“…Cancer cells can move through tissues in a variety of different ways. In some cases, an epithelial-to-mesenchymal transition enables cancer cells to acquire…”
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YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration by Yui, Shiro, Azzolin, Luca, Maimets, Martti, Pedersen, Marianne Terndrup, Fordham, Robert P., Hansen, Stine L., Larsen, Hjalte L., Guiu, Jordi, Alves, Mariana R.P., Rundsten, Carsten F., Johansen, Jens V., Li, Yuan, Madsen, Chris D., Nakamura, Tetsuya, Watanabe, Mamoru, Nielsen, Ole H., Schweiger, Pawel J., Piccolo, Stefano, Jensen, Kim B.

“…Tissue regeneration requires dynamic cellular adaptation to the wound environment. It is currently unclear how this is orchestrated at the cellular level and…”
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ISDoT: in situ decellularization of tissues for high-resolution imaging and proteomic analysis of native extracellular matrix by Mayorca-Guiliani, Alejandro E, Madsen, Chris D, Cox, Thomas R, Horton, Edward R, Venning, Freja A, Erler, Janine T

“…By surgically directing the vascular delivery of decellularization reagents, the in situ decellularization of desired organs or tissues in mice can be…”
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Decellularization and antibody staining of mouse tissues to map native extracellular matrix structures in 3D by Mayorca-Guiliani, Alejandro E, Willacy, Oliver, Madsen, Chris D., Rafaeva, Maria, Elisabeth Heumüller, Stefanie, Bock, Felix, Sengle, Gerhard, Koch, Manuel, Imhof, Thomas, Zaucke, Frank, Wagener, Raimund, Sasaki, Takako, Erler, Janine T., Reuten, Raphael

“…The extracellular matrix (ECM) is a major regulator of homeostasis and disease, yet the 3D structure of the ECM remains poorly understood because of…”
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uPAR-Induced Cell Adhesion and Migration: Vitronectin Provides the Key by Madsen, Chris D., Ferraris, Gian Maria Sarra, Andolfo, Annapaola, Cunningham, Orla, Sidenius, Nicolai

“…Expression of the membrane receptor uPAR induces profound changes in cell morphology and migration, and its expression correlates with the malignant phenotype…”
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Clathrin and LRP-1-independent constitutive endocytosis and recycling of uPAR by Cortese, Katia, Sahores, Macarena, Madsen, Chris D, Tacchetti, Carlo, Blasi, Francesco

“…The urokinase receptor (uPAR/CD87) is highly expressed in malignant tumours. uPAR, as a GPI anchored protein, is preferentially located at the cell surface,…”
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Monomer-dimer dynamics and distribution of GPI-anchored uPAR are determined by cell surface protein assemblies by Caiolfa, Valeria R, Zamai, Moreno, Malengo, Gabriele, Andolfo, Annapaola, Madsen, Chris D, Sutin, Jason, Digman, Michelle A, Gratton, Enrico, Blasi, Francesco, Sidenius, Nicolai

“…To search for functional links between glycosylphosphatidylinositol (GPI) protein monomer-oligomer exchange and membrane dynamics and confinement, we studied…”
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Pancreatic cancer is suppressed by fibroblast-derived collagen I by Madsen, Chris D.

“…Clinical implementation of anti-stromal therapies in pancreatic cancer has been delayed by unanticipated tumor-restraining properties of the desmoplastic…”
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The STRIPAK Complex Regulates Response to Chemotherapy Through p21 and p27 by Rodriguez-Cupello, Carmen, Dam, Monica, Serini, Laura, Wang, Shan, Lindgren, David, Englund, Emelie, Kjellman, Pontus, Axelson, Håkan, García-Mariscal, Alberto, Madsen, Chris D

“…The STRIPAK complex has been linked to a variety of biological processes taking place during embryogenesis and development, but its role in cancer has only…”
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Cancer cells' ability to mechanically adjust to extracellular matrix stiffness correlates with their invasive potential by Wullkopf, Lena, West, Ann-Katrine V, Leijnse, Natascha, Cox, Thomas R, Madsen, Chris D, Oddershede, Lene B, Erler, Janine T

“…Increased tissue stiffness is a classic characteristic of solid tumors. One of the major contributing factors is increased density of collagen fibers in the…”
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CCM3 is a gatekeeper in focal adhesions regulating mechanotransduction and YAP/TAZ signalling by Wang, Shan, Englund, Emelie, Kjellman, Pontus, Li, Zhen, Ahnlide, Johannes Kumra, Rodriguez-Cupello, Carmen, Saggioro, Mattia, Kanzaki, Ryu, Pietras, Kristian, Lindgren, David, Axelson, Håkan, Prinz, Christelle N, Swaminathan, Vinay, Madsen, Chris D

“…The YAP/TAZ transcriptional programme is not only a well-established driver of cancer progression and metastasis but also an important stimulator of tissue…”
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STRIPAK components determine mode of cancer cell migration and metastasis by Madsen, Chris D., Hooper, Steven, Tozluoglu, Melda, Bruckbauer, Andreas, Fletcher, Georgina, Erler, Janine T., Bates, Paul A., Thompson, Barry, Sahai, Erik

“…The contractile actomyosin cytoskeleton and its connection to the plasma membrane are critical for control of cell shape and migration. We identify three…”
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Basement membrane stiffness determines metastases formation by Reuten, Raphael, Zendehroud, Sina, Nicolau, Monica, Fleischhauer, Lutz, Laitala, Anu, Kiderlen, Stefanie, Nikodemus, Denise, Wullkopf, Lena, Nielsen, Sebastian Rune, McNeilly, Sarah, Prein, Carina, Rafaeva, Maria, Schoof, Erwin M., Furtwängler, Benjamin, Porse, Bo T., Kim, Hyobin, Won, Kyoung Jae, Sudhop, Stefanie, Zornhagen, Kamilla Westarp, Suhr, Frank, Maniati, Eleni, Pearce, Oliver M. T., Koch, Manuel, Oddershede, Lene Broeng, Van Agtmael, Tom, Madsen, Chris D., Mayorca-Guiliani, Alejandro E., Bloch, Wilhelm, Netz, Roland R., Clausen-Schaumann, Hauke, Erler, Janine T.

“…The basement membrane (BM) is a special type of extracellular matrix and presents the major barrier cancer cells have to overcome multiple times to form…”
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Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis by Madsen, Chris D, Pedersen, Jesper T, Venning, Freja A, Singh, Lukram Babloo, Moeendarbary, Emad, Charras, Guillaume, Cox, Thomas R, Sahai, Erik, Erler, Janine T

“…Cancer‐associated fibroblasts (CAFs) interact with tumour cells and promote growth and metastasis. Here, we show that CAF activation is reversible: chronic…”
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Retraction Note: CCM3 is a gatekeeper in focal adhesions regulating mechanotransduction and YAP/TAZ signalling by Wang, Shan, Englund, Emelie, Kjellman, Pontus, Li, Zhen, Ahnlide, Johannes Kumra, Rodriguez-Cupello, Carmen, Saggioro, Mattia, Kanzaki, Ryu, Pietras, Kristian, Lindgren, David, Axelson, Håkan, Prinz, Christelle N., Swaminathan, Vinay, Madsen, Chris D.

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The interaction between uPAR and vitronectin triggers ligand-independent adhesion signalling by integrins by Ferraris, Gian Maria Sarra, Schulte, Carsten, Buttiglione, Valentina, De Lorenzi, Valentina, Piontini, Andrea, Galluzzi, Massimiliano, Podestà, Alessandro, Madsen, Chris D, Sidenius, Nicolai

“…The urokinase‐type plasminogen activator receptor (uPAR) is a non‐integrin vitronectin (VN) cell adhesion receptor linked to the plasma membrane by a…”
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The interaction between urokinase receptor and vitronectin in cell adhesion and signalling by Madsen, Chris D, Sidenius, Nicolai

“…The extracellular matrix (ECM) is a complex structural entity surrounding and supporting cells present in all tissue and organs. Cell-matrix interactions play…”
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miR-23b regulates cytoskeletal remodeling, motility and metastasis by directly targeting multiple transcripts by Pellegrino, Loredana, Stebbing, Justin, Braga, Vania M, Frampton, Adam E, Jacob, Jimmy, Buluwela, Lakjaya, Jiao, Long R, Periyasamy, Manikandan, Madsen, Chris D, Caley, Matthew P, Ottaviani, Silvia, Roca-Alonso, Laura, El-Bahrawy, Mona, Coombes, R Charles, Krell, Jonathan, Castellano, Leandro

“…Uncontrolled cell proliferation and cytoskeletal remodeling are responsible for tumor development and ultimately metastasis. A number of studies have…”
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Arkadia Regulates Tumor Metastasis by Modulation of the TGF-β Pathway by BRIONES-ORTA, Marco A, LEVY, Laurence, MADSEN, Chris D, DAS, Debipriya, ERKER, Yigit, SAHAI, Erik, HILL, Caroline S

“…TGF-β can act as a tumor suppressor at early stages of cancer progression and as a tumor promoter at later stages. The E3 ubiquitin ligase Arkadia (RNF111) is…”
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