Search Results - "Madsen, Cathy"

Immune recognition of tumor-associated mucin MUC1 is achieved by a fully synthetic aberrantly glycosylated MUC1 tripartite vaccine by Lakshminarayanan, Vani, Thompson, Pamela, Wolfert, Margreet A, Buskas, Therese, Bradley, Judy M, Pathangey, Latha B, Madsen, Cathy S, Cohen, Peter A, Gendler, Sandra J, Boons, Geert-Jan

“…The mucin MUC1 is typically aberrantly glycosylated by epithelial cancer cells manifested by truncated O-linked saccharides. The resultant glycopeptide…”
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MUC1 Vaccines, Comprised of Glycosylated or Non-Glycosylated Peptides or Tumor-Derived MUC1, Can Circumvent Immunoediting to Control Tumor Growth in MUC1 Transgenic Mice by Lakshminarayanan, Vani, Supekar, Nitin T, Wei, Jie, McCurry, Dustin B, Dueck, Amylou C, Kosiorek, Heidi E, Trivedi, Priyanka P, Bradley, Judy M, Madsen, Cathy S, Pathangey, Latha B, Hoelzinger, Dominique B, Wolfert, Margreet A, Boons, Geert-Jan, Cohen, Peter A, Gendler, Sandra J

“…It remains challenging to produce decisive vaccines against MUC1, a tumor-associated antigen widely expressed by pancreas, breast and other tumors. Employing…”
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A Tissue Engineered Construct for Laryngeal Regeneration: A Proof‐of‐Concept Device Design Study by Lott, David G., Shah, Manisha, Myers, Cheryl, McPhail, Michael, Neubauer, Juergen, Struthers, Jason, Madsen, Cathy S., Grandjean, Danielle, Zacharias, Stephanie R. C., Tchoukalova, Yourka D.

“…Objectives/Hypothesis Develop a patient‐specific tissue engineered construct for laryngeal reconstruction following a partial laryngectomy. Study Design Bench…”
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The neurotrophic potential of human platelet lysate substitution for fetal bovine serum in glial induction culture medium by Ravenkamp, Maile, Tchoukalova, Yourka D., Myers, Cheryl E., Madsen, Cathy S., Shah, Manisha K., Zhang, Nan, Lal, Devyani, Lott, David G.

“…•Human platelet lysate, a xeno-free alternative to FBS, was used to create a glial induction culture medium (M-PLT).•ASC in M-PLT express established glial…”
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Muc1 is protective during kidney ischemia-reperfusion injury by Pastor-Soler, Núria M, Sutton, Timothy A, Mang, Henry E, Kinlough, Carol L, Gendler, Sandra J, Madsen, Cathy S, Bastacky, Sheldon I, Ho, Jacqueline, Al-Bataineh, Mohammad M, Hallows, Kenneth R, Singh, Sucha, Monga, Satdarshan P, Kobayashi, Hanako, Haase, Volker H, Hughey, Rebecca P

“…Ischemia-reperfusion injury (IRI) due to hypotension is a common cause of human acute kidney injury (AKI). Hypoxia-inducible transcription factors (HIFs)…”
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Synthesis and Immunological Evaluation of a Multicomponent Cancer Vaccine Candidate Containing a Long MUC1 Glycopeptide by Supekar, Nitin T., Lakshminarayanan, Vani, Capicciotti, Chantelle J., Sirohiwal, Anju, Madsen, Cathy S., Wolfert, Margreet A., Cohen, Peter A., Gendler, Sandra J., Boons, Geert‐Jan

“…A fully synthetic MUC1‐based cancer vaccine was designed and chemically synthesized containing an endogenous helper T‐epitope (MHC class II epitope). The…”
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Muc1 enhances the β-catenin protective pathway during ischemia-reperfusion injury by Al-Bataineh, Mohammad M, Kinlough, Carol L, Poland, Paul A, Pastor-Soler, Núria M, Sutton, Timothy A, Mang, Henry E, Bastacky, Sheldon I, Gendler, Sandra J, Madsen, Cathy S, Singh, Sucha, Monga, Satdarshan P, Hughey, Rebecca P

“…The hypoxia-inducible factor (HIF)-1 and β-catenin protective pathways represent the two most significant cellular responses that are activated in response to…”
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Human amniotic epithelial cell transplantation improves scar remodeling in a rabbit model of acute vocal fold injury: a pilot study by Tchoukalova, Yourka D, Zacharias, Stephanie R C, Mitchell, Natalie, Madsen, Cathy, Myers, Cheryl E, Gadalla, Dina, Skinner, Jessica, Kopaczka, Katarzyna, Gramignoli, Roberto, Lott, David G

“…To gain insight into the molecular mechanisms underlying the early stages of vocal fold extracellular matrix (ECM) remodeling after a mid-membranous injury…”
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Downregulation of Hematopoietic MUC1 during Experimental Colitis Increases Tumor-Promoting Myeloid-Derived Suppressor Cells by WEI POH, Tze, MADSEN, Cathy S, GORMAN, Jessica E, MARLER, Ronald J, LEIGHTON, Jonathan A, COHEN, Peter A, GENDLER, Sandra J

“…MUC1 is a tumor-associated antigen that is aberrantly expressed in cancer and inflammatory bowel disease (IBD). Even though immune cells express low MUC1…”
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Mucin 1-specific immunotherapy in a mouse model of spontaneous breast cancer by MUKHERJEE, Pinku, MADSEN, Cathy S, GINARDI, Amelia R, TINDER, Teresa L, JACOBS, Fred, PARKER, Joanne, AGRAWAL, Babita, LONGENECKER, B. Michael, GENDLER, Sandra J

“…Human mucin 1 (MUC1) is an epithelial mucin glycoprotein that is overexpressed in 90% of all adenocarcinomas including breast, lung, pancreas, prostate,…”
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Characterization of the MUC1.Tg/MIN transgenic mouse as a model for studying antigen-specific immunotherapy of adenomas by Akporiaye, Emmanuel T, Bradley-Dunlop, Deborah, Gendler, Sandra J, Mukherjee, Pinku, Madsen, Cathy S, Hahn, Tobias, Besselsen, David G, Dial, Sharon M, Cui, Haiyan, Trevor, Katrina

“…Abstract A bigenic MUC1.Tg/MIN mouse model was developed by crossing Apc/ MIN/+ (MIN) mice with human MUC1 transgenic mice to evaluate MUC1 antigen-specific…”
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Mice with Spontaneous Pancreatic Cancer Naturally Develop MUC-1-Specific CTLs That Eradicate Tumors When Adoptively Transferred by Mukherjee, Pinku, Ginardi, Amelia R, Madsen, Cathy S, Sterner, Christopher J, Adriance, Melissa C, Tevethia, Mary J, Gendler, Sandra J

“…Pancreatic cancer is a highly aggressive, treatment refractory cancer and is the fourth leading cause of death in the United States. In humans, 90% of…”
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MUC1-specific CTLs are non-functional within a pancreatic tumor microenvironment by Mukherjee, P, Ginardi, A R, Madsen, C S, Tinder, T L, Jacobs, F, Parker, J, Agrawal, B, Longenecker, B M, Gendler, S J

“…Pancreatic cancer is a highly aggressive, treatment refractory disease and is the fourth leading cause of death in the United States. In humans, 90% of…”
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Novel MUC1 splice variants contribute to mucin overexpression in CFTR-deficient mice by Hinojosa-Kurtzberg, A Marina, Johansson, Malin E V, Madsen, Cathy S, Hansson, Gunnar C, Gendler, Sandra J

“…A cystic fibrosis (CF) mouse expressing the human mucin MUC1 transgene (CFM) reverted the CF/Muc1(-/-) phenotype (little mucus accumulated in the intestine) to…”
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The MUC1 Cytoplasmic Tail and Tandem Repeat Domains Contribute to Mammary Oncogenesis in FVB Mice by Hattrup, Christine L, Bradley, Judy M, Kotlarczyk, Kari L, Madsen, Cathy S, Hentz, Joseph G, Marler, Ronald J, Gendler, Sandra J

“…Though the importance of the transmembrane mucin MUC1 in mammary oncogenesis has long been recognized, the relative contributions of the cytoplasmic tail and…”
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Dendritic Cell–Tumor Cell Fusion and Staphylococcal Enterotoxin B Treatment in a Pancreatic Tumor Model by McConnell, Elizabeth J., Pathangey, Latha B., Madsen, Cathy S., Gendler, Sandra J., Mukherjee, Pinku

“…Background. Surgical resection of pancreatic tumors removes gross disease but not metastases. Adjuvant therapy such as chemotherapy and radiation treatment is…”
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Modified EPR spectra of the tyrosineD radical in photosystem II in site-directed mutants of Synechocystis sp. PCC 6803: Identification of side chains in the immediate vicinity of tyrosineD on the D2 protein by Tommos, Cecilia, Davidsson, Lars, Svensson, Bengt, Madsen, Cathy, Vermaas, Wim, Styring, Stenbjoern

“…The oxidizing side of photosystem II contains two redox-active tyrosyl side chains, Tyr(Z) and Tyr(D), and a cluster of Mn atoms involved in water oxidation…”
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Muc1 Modulates the Beta‐Catenin Protective Pathway During Ischemia‐Reperfusion Injury by Al‐bataineh, Mohammad M, Kinlough, Carol L, Pastor‐Soler, Nuria M, Sutton, Timothy A, Poland, Paul A, Mang, Henry E, Gendler, Sandra J, Madsen, Cathy S, Singh, Sucha, Bastacky, Sheldon I, Monga, Satdarshan P, Hughey, Rebecca P

“…Abstract only The HIF‐1 and β‐catenin protective pathways represent the two most significant cellular responses that are activated in response to acute kidney…”
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The MUC1 Cytoplasmic Tail and Tandem Repeat Domains Contribute to Mammary Oncogenesis in FVB Mice by Hattrup, Christine L., Bradley, Judy M., Kotlarczyk, Kari L., Madsen, Cathy S., Hentz, Joseph G., Marler, Ronald J., Gendler, Sandra J.

“…Christine L. Hattrup1,3, Judy M. Bradley, Kari L. Kotlarczyk, Cathy S. Madsen, Joseph G. Hentz, Ronald J. Marler2 and Sandra J. Gendler1 1Department of…”
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Inositol hexaphosphate alters mucin expression in the intestinal mucosa of mice by Onyango, Edward, Madsen, Cathy, Gendler, Sandra

“…Abstract only Inositol hexaphosphate (IP6 or phytic acid) is thought to be the active ingredient in legumes and cereals that provides anti‐cancer activity. Our…”
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