Search Results - "Madireddy, Advaitha"

BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage by Kang, Zhihua, Fu, Pan, Alcivar, Allen L., Fu, Haiqing, Redon, Christophe, Foo, Tzeh Keong, Zuo, Yamei, Ye, Caiyong, Baxley, Ryan, Madireddy, Advaitha, Buisson, Remi, Bielinsky, Anja-Katrin, Zou, Lee, Shen, Zhiyuan, Aladjem, Mirit I., Xia, Bing

“…The BRCA2 tumor suppressor protects genome integrity by promoting homologous recombination-based repair of DNA breaks, stability of stalled DNA replication…”
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Visualizing DNA replication by single-molecule analysis of replicated DNA by Madireddy, Advaitha, Gerhardt, Jeannine

“…Single-molecule analysis of replicated DNA (SMARD) is a unique technique that enables visualization of DNA replication at specific genomic regions at…”
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Translesion polymerase eta both facilitates DNA replication and promotes increased human genetic variation at common fragile sites by Twayana, Shyam, Bacolla, Albino, Barreto-Galvez, Angelica, De-Paula, Ruth B., Drosopoulos, William C., Kosiyatrakul, Settapong T., Bouhassira, Eric E., Tainer, John A., Madiredd, Advaitha, Schildkraut, Carl L.

“…Common fragile sites (CFSs) are difficult-to-replicate genomic regions that form gaps and breaks on metaphase chromosomes under replication stress. They are…”
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G-quadruplex-interacting compounds alter latent DNA replication and episomal persistence of KSHV by Madireddy, Advaitha, Purushothaman, Pravinkumar, Loosbroock, Christopher P, Robertson, Erle S, Schildkraut, Carl L, Verma, Subhash C

“…Kaposi's sarcoma associated herpesvirus (KSHV) establishes life-long latent infection by persisting as an extra-chromosomal episome in the infected cells and…”
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High burden of clonal hematopoiesis in first responders exposed to the World Trade Center disaster by Jasra, Sakshi, Giricz, Orsi, Zeig-Owens, Rachel, Pradhan, Kith, Goldfarb, David G., Barreto-Galvez, Angelica, Silver, Alexander J., Chen, Jiahao, Sahu, Srabani, Gordon-Mitchell, Shanisha, Choudhary, Gaurav S., Aluri, Srinivas, Bhagat, Tushar D., Shastri, Aditi, Bejan, Cosmin A., Stockton, Shannon S., Spaulding, Travis P., Thiruthuvanathan, Victor, Goto, Hiroki, Gerhardt, Jeannine, Haider, Syed Hissam, Veerappan, Arul, Bartenstein, Matthias, Nwankwo, George, Landgren, Ola, Weiden, Michael D., Lekostaj, Jacqueline, Bender, Ryan, Fletcher, Frederick, Greenberger, Lee, Ebert, Benjamin L., Steidl, Ulrich, Will, Britta, Nolan, Anna, Madireddy, Advaitha, Savona, Michael R., Prezant, David J., Verma, Amit

“…The terrorist attacks on the World Trade Center (WTC) created an unprecedented environmental exposure to aerosolized dust, gases and potential carcinogens…”
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Editorial: Chromosomal fragile sites, genome instability and human diseases by Hu, Qing, Madireddy, Advaitha, Gnan, Stefano, Chen, Chun-Long

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Cis-acting DNA sequence at a replication origin promotes repeat expansion to fragile X full mutation by Gerhardt, Jeannine, Zaninovic, Nikica, Zhan, Qiansheng, Madireddy, Advaitha, Nolin, Sarah L, Ersalesi, Nicole, Yan, Zi, Rosenwaks, Zev, Schildkraut, Carl L

“…Fragile X syndrome (FXS) is caused by CGG repeat expansion that leads to FMR1 silencing. Women with a premutation allele are at risk of having a full mutation…”
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Multiple DNA Binding Domains Mediate the Function of the ERCC1-XPF Protein in Nucleotide Excision Repair by Su, Yan, Orelli, Barbara, Madireddy, Advaitha, Niedernhofer, Laura J., Schärer, Orlando D.

“…ERCC1-XPF is a heterodimeric, structure-specific endonuclease that cleaves single-stranded/double-stranded DNA junctions and has roles in nucleotide excision…”
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FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres by Pan, Xiaolei, Drosopoulos, William C., Sethi, Louisa, Madireddy, Advaitha, Schildkraut, Carl L., Zhang, Dong

“…In the mammalian genome, certain genomic loci/regions pose greater challenges to the DNA replication machinery (i.e., the replisome) than others. Such known…”
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Acetyl Transferase EP300 Deficiency Leads to Chronic Replication Stress in Adult T-Cell Leukemia/Lymphoma by Niljikar, Mrunmai, Juwarwala, Aastha, Gagliardi, Julia, Zhang, Ranran, Ye, B. Hilda, Madireddy, Advaitha

“…Mutations in the epigenetic regulator and global transcriptional activator, E1A binding protein (EP300), is being increasingly reported in aggressive…”
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The Cause and Consequence of Replication Stress in Adult T-Cell Leukemia by Barreto-Galvez, Angelica, Madireddy, Advaitha, Ye, B. Hilda, Gagliardi, Julia, Juwarwala, Aastha, Pradeep, Archana, Niljikar, Mrunmai

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Understanding the Mechanisms Driving Genomic Instability in Adult T-Cell Leukemia/Lymphoma by Madireddy, Advaitha, Barreto-Galvez, Angelica, Ye, B. Hilda

“…Adult T-cell Leukemia/Lymphoma (ATLL) is a T-cell malignancy that results from infection by the retrovirus, human T cell lymphotropic virus-1 (HTLV-1). ATLL is…”
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Error-prone repair of stalled replication forks drives mutagenesis and loss of heterozygosity in haploinsufficient BRCA1 cells by Deshpande, Madhura, Paniza, Theodore, Jalloul, Nahed, Nanjangud, Gouri, Twarowski, Jerzy, Koren, Amnon, Zaninovic, Nikica, Zhan, Qiansheng, Chadalavada, Kalyani, Malkova, Anna, Khiabanian, Hossein, Madireddy, Advaitha, Rosenwaks, Zev, Gerhardt, Jeannine

“…Germline mutations in the BRCA genes are associated with a higher risk of carcinogenesis, which is linked to an increased mutation rate and loss of the second…”
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Adult T-Cell Leukemia/Lymphoma Diagnosed in North American Is Characterized By a Requirement for BCL6 and a Cell Cycle Program Associated with DNA Replication Stress by Ye, B. Hilda, Chung, Elaine, Ren, Xiaoxin, Pradhan, Kith, Wang, Yanhua, Madireddy, Advaitha, Zang, Xingxing, Janakiram, Murali, Sica, R. Alejandro, Verma, Amit

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FANCD2 Facilitates Replication through Common Fragile Sites by Madireddy, Advaitha, Kosiyatrakul, Settapong T., Boisvert, Rebecca A., Herrera-Moyano, Emilia, García-Rubio, María L., Gerhardt, Jeannine, Vuono, Elizabeth A., Owen, Nichole, Yan, Zi, Olson, Susan, Aguilera, Andrés, Howlett, Niall G., Schildkraut, Carl L.

“…Common fragile sites (CFSs) are genomic regions that are unstable under conditions of replicative stress. Although the characteristics of CFSs that render them…”
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Temporal and structural patterns of hepatitis B virus integrations in hepatocellular carcinoma by Ren, Haozhen, Chen, Xun, Wang, Jinglin, Chen, Ying, Hafiz, Alex, Xiao, Qian, Fu, Shiwei, Madireddy, Advaitha, Li, Wei Vivian, Shi, Xiaolei, Cao, Jian

“…Chronic infection of hepatitis B virus (HBV) is the major cause of hepatocellular carcinoma (HCC). Notably, 90% of HBV‐positive HCC cases exhibit detectable…”
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Pluripotent stem cells with low differentiation potential contain incompletely reprogrammed DNA replication by Paniza, Theodore, Deshpande, Madhura, Wang, Ning, O'Neil, Ryan, Zuccaro, Michael V, Smith, Morgan Elizabeth, Madireddy, Advaitha, James, Daylon, Ecker, Joseph, Rosenwaks, Zev, Egli, Dieter, Gerhardt, Jeannine

“…Reprogrammed pluripotent stem cells (PSCs) are valuable for research and potentially for cell replacement therapy. However, only a fraction of reprogrammed…”
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Functional mapping of PHF6 complexes in chromatin remodeling, replication dynamics, and DNA repair by Alvarez, Silvia, da Silva Almeida, Ana C., Albero, Robert, Biswas, Mayukh, Barreto-Galvez, Angelica, Gunning, Thomas S., Shaikh, Anam, Aparicio, Tomas, Wendorff, Agnieszka, Piovan, Erich, Van Vlierberghe, Pieter, Gygi, Steven, Gautier, Jean, Madireddy, Advaitha, Ferrando, Adolfo A.

“…The Plant Homeodomain 6 gene (PHF6) encodes a nucleolar and chromatin-associated leukemia tumor suppressor with proposed roles in transcription regulation…”
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S-Phase Progression of North American ATLL Cells Is Critically Regulated By the Proto-Oncogene BCL6 and Targetable By PARP Inhibition by Ye, B. Hilda, Chung, Elaine, Pradhan, Kith, Acuna-Villaorduna, Ana, Wang, Yanhua, Shastri, Aditi, Madireddy, Advaitha, Verma, Amit, Sica, R.Alejandro, Janakiram, Murali

“…Adult T-cell leukemia/lymphoma (ATLL) is a disease of malignant T cells that develops in human T-lymphotropic virus-1 (HTLV-1) carriers. ATLL is one of the…”
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2009 – WORLD TRADE CENTER 9/11 DISASTER EXPOSURE IS ASSOCIATED WITH CLONAL HEMATOPOIESIS IN FIRST RESPONDERS AND IS CHARACTERIZED BY INNATE IMMUNE INFLAMMATION by Verma, Divij, Giricz, Orsi, Zeig-Owens, Rachel, Pradhan, Kith, Zou, yiyu, Goldfarb, David D, Sahu, Srabani, Jasra, Sakshi, kelly, Susheian, Aluri, Srinivas, Gordon-Mitchell, Shanisha, Nolan, Anna, Weiden, Michael, Hall, Charles, Shastri, Aditi, Madireddy, Advaitha, Savona, Michael, Steidl, Ulrich G, Prezant, David J, Verma, Amit

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