Search Results - "Madhvani, Roshni"

Shaping a new Ca2+ conductance to suppress early afterdepolarizations in cardiac myocytes by Madhvani, Roshni V., Xie, Yuanfang, Pantazis, Antonios, Garfinkel, Alan, Qu, Zhilin, Weiss, James N., Olcese, Riccardo

“…Non‐technical summary  Diseases, genetic defects, or ionic imbalances can alter the normal electrical activity of cardiac myocytes causing an anomalous heart…”
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Targeting the late component of the cardiac L-type Ca2+ current to suppress early afterdepolarizations by Madhvani, Roshni V, Angelini, Marina, Xie, Yuanfang, Pantazis, Antonios, Suriany, Silvie, Borgstrom, Nils P, Garfinkel, Alan, Qu, Zhilin, Weiss, James N, Olcese, Riccardo

“…Early afterdepolarizations (EADs) associated with prolongation of the cardiac action potential (AP) can create heterogeneity of repolarization and premature…”
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Stochastic pacing reveals the propensity to cardiac action potential alternans and uncovers its underlying dynamics by Prudat, Yann, Madhvani, Roshni V., Angelini, Marina, Borgstom, Nils P., Garfinkel, Alan, Karagueuzian, Hrayr S., Weiss, James N., Lange, Enno, Olcese, Riccardo, Kucera, Jan P.

“…Key points Beat‐to‐beat alternation (alternans) of the cardiac action potential duration is known to precipitate life‐threatening arrhythmias and can be driven…”
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The Cytochrome C-Like Domain of the Human BK Channel by Yusifov, Taleh, Madhvani, Roshni V., Olcese, Riccardo

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Preclinical characterization of CK-4021586, a new class of cardiac myosin inhibitors for the treatment of hypertrophic cardiomyopathy by Sankar Sarkar, Saswata, Hartman, James J., Hwee, Darren T., Chuang, Chihyuan, Cremin, Peadar, deRosier, Andre, Edell, Samantha, Madhvani, Roshni, Wu, Yangsong, Yco, Lisette, Zamora, Jeanelle, Murphy, Anne, Morgan, Bradley P., Malik, Fady I.

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Wnt Signaling Interactor WTIP (Wilms Tumor Interacting Protein) Underlies Novel Mechanism for Cardiac Hypertrophy by De Jong, Hannah N., Dewey, Frederick E., Cordero, Pablo, Victorio, Rachelle A., Kirillova, Anna, Huang, Yong, Madhvani, Roshni, Seo, Kinya, Werdich, Andreas A., Lan, Feng, Orcholski, Mark, Robert Liu, W., Erbilgin, Ayca, Wheeler, Matthew T., Chen, Rui, Pan, Stephen, Kim, Young M., Bommakanti, Krishna, Marcou, Cherisse A., Martijn Bos, J., Haddad, Francois, Ackerman, Michael, Vasan, Ramachandran S., MacRae, Calum, Wu, Joseph C., de Jesus Perez, Vinicio, Snyder, Michael, Parikh, Victoria N., Ashley, Euan A.

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Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy by Hartman, James J, Hwee, Darren T, Robert-Paganin, Julien, Chuang, Chihyuan, Chin, Eva R, Edell, Samantha, Lee, Ken H, Madhvani, Roshni, Paliwal, Preeti, Pernier, Julien, Sarkar, Saswata Sankar, Schaletzky, Julia, Schauer, Kristine, Taheri, Khanha D, Wang, Jingying, Wehri, Eddie, Wu, Yangsong, Houdusse, Anne, Morgan, Bradley P, Malik, Fady I

“…Hypertrophic cardiomyopathy (HCM) is an inherited disease of the sarcomere resulting in excessive cardiac contractility. The first-in-class cardiac myosin…”
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Mono- and Biallelic Protein-Truncating Variants in Alpha-Actinin 2 Cause Cardiomyopathy Through Distinct Mechanisms by Lindholm, Malene E., Jimenez-Morales, David, Zhu, Han, Seo, Kinya, Amar, David, Zhao, Chunli, Raja, Archana, Madhvani, Roshni, Abramowitz, Sarah, Espenel, Cedric, Sutton, Shirley, Caleshu, Colleen, Berry, Gerald J., Motonaga, Kara S., Dunn, Kyla, Platt, Julia, Ashley, Euan A., Wheeler, Matthew T.

“…ACTN2 (alpha-actinin 2) anchors actin within cardiac sarcomeres. The mechanisms linking mutations to myocardial disease phenotypes are unknown. Here, we…”
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Tuning L-Type Ca2+ Current Properties to Suppress Early After depolarizations by Madhvani, Roshni V., Xie, Yuanfang, Pantazis, Antonios, Garfinkel, Alan, Qu, Zhilin, Weiss, James N., Olcese, Riccardo

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Targeting the late component of the cardiac L-type Ca^sup 2+^ current to suppress early afterdepolarizations by Madhvani, Roshni V, Angelini, Marina, Xie, Yuanfang, Pantazis, Antonios, Suriany, Silvie, Borgstrom, Nils P, Garfinkel, Alan, Qu, Zhilin, Weiss, James N, Olcese, Riccardo

“…Early afterdepolarizations (EADs) associated with prolongation of the cardiac action potential (AP) can create heterogeneity of repolarization and premature…”
Get full text

Targeting the Late Component of the Cardiac L-type Ca 2+ Current to Suppress Early Afterdepolarizations by Madhvani, Roshni V., Angelini, Marina, Xie, Yuanfang, Pantazis, Antonios, Suriany, Silvie, Borgstrom, Nils P., Garfinkel, Alan, Qu, Qu, Weiss, James N., Olcese, Riccardo

“…Early afterdepolarizations (EADs) associated with prolongation of the cardiac action potential (AP) can create heterogeneity of repolarization and premature…”
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How do L-Type Calcium Current Kinetics Contribute to Early After Depolarizations in Cardiac Myocytes? by Madhvani, Roshni V., Xie, Yuanfang, Pantazis, Antonios, Garfinkel, Alan, Qu, Zhilin, Weiss, James N., Olcese, Riccardo

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Shaping a new Ca 2+ conductance to suppress early afterdepolarizations in cardiac myocytes by Madhvani, Roshni V., Xie, Yuanfang, Pantazis, Antonios, Garfinkel, Alan, Qu, Zhilin, Weiss, James N., Olcese, Riccardo

“…Non‐technical summary  Diseases, genetic defects, or ionic imbalances can alter the normal electrical activity of cardiac myocytes causing an anomalous heart…”
Get full text

Mono- and Biallelic Protein-Truncating Variants in Alpha-Actinin 2 Cause Cardiomyopathy Through Distinct Mechanisms by Lindholm, Malene E., Jimenez-Morales, David, Zhu, Han, Seo, Kinya, Amar, David, Zhao, Chunli, Raja, Archana, Madhvani, Roshni, Abramowitz, Sarah, Espenel, Cedric, Sutton, Shirley, Caleshu, Colleen, Berry, Gerald J., Motonaga, Kara S., Dunn, Kyla, Platt, Julia, Ashley, Euan A., Wheeler, Matthew T.

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Mono- and Bi-allelic Protein Truncating Variants in Alpha-actinin 2 cause Cardiomyopathy through Distinct Mechanisms by Lindholm, Malene E., Jimenez-Morales, David, Zhu, Han, Seo, Kinya, Amar, David, Zhao, Chunli, Raja, Archana, Madhvani, Roshni, Abramowitz, Sarah, Espenel, Cedric, Sutton, Shirley, Caleshu, Colleen, Berry, Gerald J., Motonaga, Kara S., Dunn, Kyla, Platt, Julia, Ashley, Euan A., Wheeler, Matthew T.

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Suppressing Early Afterdepolarizations in Cardiac Myocytes by Shaping a Modified Ca2+ Conductance Under Dynamic Clamp by Madhvani, Roshni V., Xie, Yuanfang, Pantazis, Antonios, Garfinkel, Alan, Qu, Zhilin, Weiss, James N., Olcese, Riccardo

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Suppressing Early Afterdepolarizations in Cardiac Myocytes by Shaping a Modified Ca 2+ Conductance Under Dynamic Clamp by Madhvani, Roshni V., Xie, Yuanfang, Pantazis, Antonios, Garfinkel, Alan, Qu, Zhilin, Weiss, James N., Olcese, Riccardo

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Wnt Signaling Interactor WTIP (Wilms Tumor Interacting Protein) Underlies Novel Mechanism for Cardiac Hypertrophy by De Jong, Hannah N., Dewey, Frederick E., Cordero, Pablo, Victorio, Rachelle A., Kirillova, Anna, Huang, Yong, Madhvani, Roshni, Seo, Kinya, Werdich, Andreas A., Lan, Feng, Orcholski, Mark, Liu, W. Robert, Erbilgin, Ayca, Wheeler, Matthew T., Chen, Rui, Pan, Stephen, Kim, Young M., Bommakanti, Krishna, Marcou, Cherisse A., Bos, J. Martijn, Haddad, Francois, Ackerman, Michael, Vasan, Ramachandran S., MacRae, Calum, Wu, Joseph C., de Jesus Perez, Vinicio, Snyder, Michael, Parikh, Victoria N., Ashley, Euan A.

“…The study of hypertrophic cardiomyopathy (HCM)-a severe Mendelian disease-can yield insight into the mechanisms underlying the complex trait of cardiac…”
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L-type Ca2+ channels as therapeutic targets for Early afterdepolarization-related arrhythmias by Madhvani, Roshni Vyas

“…Early afterdepolarizations (EADs) are highly arrhythmogenic transient depolarizations occurring during phase 2 or 3 of the cardiac action potential (AP). Using…”
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Site-Directed Alkylation of Cysteine Replacements in the Lactose Permease of Escherichia coli:  Helices I, III, VI, and XI by Ermolova, Natalia, Madhvani, Roshni Vyas, Kaback, H. Ronald

“…To complete a study on site-directed alkylation of Cys replacements in the lactose permease of Escherichia coli (LacY), the reactivity of single-Cys mutants in…”
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