Search Results - "Madhusudan, N."
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TGF-β: the connecting link between nephropathy and fibrosis
Published in Immunopharmacology and immunotoxicology (02-01-2016)“…Renal fibrosis is the usual outcome of an excessive accumulation of extracellular matrix (ECM) that frequently occurs in membranous and diabetic nephropathy…”
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Novel Derivatives of Eugenol as a New Class of PPARγ Agonists in Treating Inflammation: Design, Synthesis, SAR Analysis and In Vitro Anti-Inflammatory Activity
Published in Molecules (Basel, Switzerland) (05-05-2023)“…The main objective of this research was to develop novel compounds from readily accessed natural products especially eugenol with potential biological…”
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Design, synthesis and 3D-QSAR studies of new diphenylamine containing 1,2,4-triazoles as potential antitubercular agents
Published in European journal of medicinal chemistry (12-09-2014)“…A new series of new diphenylamine containing 1,2,4-triazoles were synthesized from 4-arylideneamino-5-[2-(2,6-dichlorophenylamino)…”
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Rational design, synthesis, analysis and antifungal activity of novel myristic acid derivatives as N-myristoyltransferase inhibitors
Published in Journal of molecular structure (05-05-2024)“…•We report a new series of myristic acid derivatives as antifungal agents by inhibiting NMT.•The designed myristic acid derivatives were synthesized and…”
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Synthesis, characterization, and anti-cancer potential of novel p53-mediated Mdm2 and Pirh2 modulators: an integrated In silico and In vitro approach
Published in Frontiers in chemistry (16-07-2024)“…Leukemia is a global health concern that requires alternative treatments due to the limitations of the FDA-approved drugs. Our focus is on p53, a crucial tumor…”
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Novel derivatives of eugenol as potent anti-inflammatory agents via PPARγ agonism: rational design, synthesis, analysis, PPARγ protein binding assay and computational studies
Published in RSC advances (01-06-2022)“…Eugenol is a natural product abundantly found in clove buds known for its pharmacological activities such as anti-inflammatory, antidiabetic, antioxidant, and…”
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The introduction of the trauma triage clinic at a district general hospital: safety and efficacy during the first year of implementation
Published in Annals of the Royal College of Surgeons of England (01-05-2022)“…Previously published work has shown that there are no missed injuries following the introduction of a trauma triage clinic (TTC). This study aimed to assess…”
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Discovery of Novel Myristic Acid Derivatives as N-Myristoyltransferase Inhibitors: Design, Synthesis, Analysis, Computational Studies and Antifungal Activity
Published in Antibiotics (Basel) (01-07-2023)“…In recent years, N-Myristoyltransferase (NMT) has been identified as a new target for the treatment of fungal infections. It is observed that at present, there…”
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Stacking of Pup1 QTL for low soil phosphorus tolerance and bacterial blight resistance genes in the background of APMS6B, the maintainer line of rice hybrid DRRH-3
Published in Euphytica (01-04-2022)“…Phosphorus (P) is one of the macronutrients essential for plant growth and development. Rice ( Oryza sativa L.) is sensitive to P starvation and its deficiency…”
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Clinical and microbiological profile of enteric fever among pediatric patients in a tertiary care center in South India: A cross-sectional study
Published in Journal of clinical sciences (01-07-2020)“…Introduction: Enteric fever, which is endemic in India, is a significant cause for morbidity, particularly among young children. Enteric fever is associated…”
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The Development, Application and Analysis of an Enhanced Recovery Programme for Major Oesophagogastric Resection
Published in Journal of gastrointestinal surgery (01-04-2017)“…Background Enhanced recovery programmes improve outcomes in surgery, but their implementation after upper gastrointestinal resection has been limited. The aim…”
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A masquerading subcutaneous swelling caused by Scedosporium apiospermum: an emerging pathogen
Published in Indian journal of pathology & microbiology (01-01-2015)“…Scedosporiasis is an emerging infection in immunocompromised individuals. We report a case of multiple subcutaneous swellings in a diabetic ketoacidotic…”
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A SIMPLE HPLC-UV METHOD DEVELOPMENT AND VALIDATION FOR THE QUANTIFICATION OF DEXIBUPROFEN APPLIED IN BIOEQUIVALENCE STUDY
Published in Journal of liquid chromatography & related technologies (01-08-2012)“…A simple, rapid, and sensitive HPLC with UV detection was developed and validated for the determination of dexibuprofen in human plasma. The method involves…”
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Synthesis and in vitro cytotoxicity studies of certain novel heterocycles derived from bis 1, 2, 4-triazoles and their DNA damage studies
Published in Medicinal chemistry (Shp-sariqah, United Arab Emirates) (01-12-2013)“…Synthesis and evaluation of cytotoxicity of a series of heterocyclic compounds derived from 1, 4-bis-(5-…”
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Evaluation of ultrasound guided pectoralis nerve block for post-operative analgesia in patients undergoing modified radical mastectomy under general anaesthesia
Published in Journal of medical and scientific research (Online) (02-04-2024)“…Background: Breast cancer is one of the most common malignancies found in women across the world requiring surgery. These surgeries lead to immense…”
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In-Vitro Cytotoxicity and Cell Cycle Analysis of Two Novel bis-1,2, 4-triazole derivatives: 1,4-bis[5-(5-mercapto-1,3,4-oxadiazol-2-yl-methyl)-thio-4-(p-tolyl)-1,2,4-triazol-3-yl]-butane (MNP-14) and 1,4-bis[5-(carbethoxy-methyl)-thio-4-(p-ethoxy phenyl)-1,2,4-triazol-3-yl]-butane (MNP-16)
Published in Nucleosides, nucleotides & nucleic acids (01-11-2011)“…In the present study, we have tested the cytotoxic and DNA damage activity of two novel bis-1,2,4 triazole derivatives, namely…”
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Hepatoprotective Activity of Polyherbal Formulation (Normeta®) in Oxidative Stress Induced by Alcohol, Polyunsaturated Fatty Acids and Iron in Rats
Published in Basic & clinical pharmacology & toxicology (01-09-2009)“…: In recent years, oxidative stress has been implicated in the pathophysiology of a large number of diseases or disorders which are initiated and/or…”
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Entrepreneurship, globalization, and information technology: A case study of Webject Systems, Inc
Published in International journal of emerging markets (01-01-2007)“…Purpose The purpose of this paper is to provide an overview of and insight into the creation and success of Webject Systems, Inc., an international SME in the…”
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Blockchain Over Low Power Microcontrollers
Published in 2022 Third International Conference on Intelligent Computing Instrumentation and Control Technologies (ICICICT) (11-08-2022)“…Due to the increase in the use of digital assets, Blockchain and Crypto-currency have become the most trending technology these days. Block-chain uses a purely…”
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