Search Results - "Madhunapantula, SubbaRao V"

Mitochondrial mutations and mitoepigenetics: Focus on regulation of oxidative stress-induced responses in breast cancers by Chen, Kuo, Lu, Pengwei, Beeraka, Narasimha M., Sukocheva, Olga A., Madhunapantula, SubbaRao V., Liu, Junqi, Sinelnikov, Mikhail Y., Nikolenko, Vladimir N., Bulygin, Kirill V., Mikhaleva, Liudmila M., Reshetov, Igor V., Gu, Yuanting, Zhang, Jin, Cao, Yu, Somasundaram, Siva G., Kirkland, Cecil E., Fan, Ruitai, Aliev, Gjumrakch

“…•Epigenetic regulation of mitochondrial DNA (mtDNA) (mitoepigenetics) is an emerging and fast developing field of research.•Cancer cells contain oxidative…”
Get full text

Inhibitory Effect of Polyphenols from the Whole Green Jackfruit Flour against α-Glucosidase, α-Amylase, Aldose Reductase and Glycation at Multiple Stages and Their Interaction: Inhibition Kinetics and Molecular Simulations by Maradesha, Tejaswini, Patil, Shashank M, Al-Mutairi, Khalid Awadh, Ramu, Ramith, Madhunapantula, SubbaRao V, Alqadi, Taha

“…For the first time, α-glucosidase, α-amylase, aldose reductase, and glycation at multiple stages inhibitory assays were used to explore the antidiabetic…”
Get full text

Induction of colon and cervical cancer cell death by cinnamic acid derivatives is mediated through the inhibition of Histone Deacetylases (HDAC) by Anantharaju, Preethi G, Reddy, Deepa B, Padukudru, Mahesh A, Chitturi, Ch M Kumari, Vimalambike, Manjunath G, Madhunapantula, SubbaRao V

“…Recent studies from our group and many others have shown the ability of histone deacetylase (HDAC) inhibitors for retarding the growth of carcinomas of cervix,…”
Get full text

Virtual Screening for Identification of Dual Inhibitors against CDK4/6 and Aromatase Enzyme by Adon, Tenzin, Shanmugarajan, Dhivya, Ather, Hissana, Ansari, Shaik Mohammad Asif, Hani, Umme, Madhunapantula, SubbaRao V, Honnavalli, Yogish Kumar

“…CDK4/6 and aromatase are prominent targets for breast cancer drug discovery and are involved in abnormal cell proliferation and growth. Although aromatase…”
Get full text

Targeting the MAPK pathway in melanoma: Why some approaches succeed and other fail by Inamdar, Gajanan S., Madhunapantula, SubbaRao V., Robertson, Gavin P.

“…The Mitogen Activated Protein Kinase (MAPK) pathway plays a key role in melanoma development making it an important therapeutic target. In normal cells, the…”
Get full text

Lipid-based nanocarriers for breast cancer treatment - comprehensive review by Talluri, Siddartha Venkata, Kuppusamy, Gowthamarajan, Karri, Veera Venkata Satyanarayana Reddy, Tummala, Shashank, Madhunapantula, SubbaRao V

“…Breast cancer is the second leading cancer-related disease as the most common non-cutaneous malignancy among women. Curative options for breast cancer are…”
Get more information

The Role of Exosomes in Stemness and Neurodegenerative Diseases-Chemoresistant-Cancer Therapeutics and Phytochemicals by Beeraka, Narasimha M, Doreswamy, Shalini H, Sadhu, Surya P, Srinivasan, Asha, Pragada, Rajeswara Rao, Madhunapantula, SubbaRao V, Aliev, Gjumrakch

“…Exosomes exhibit a wide range of biological properties and functions in the living organisms. They are nanometric vehicles and used for delivering drugs, as…”
Get full text

Strategies for Targeting SARS CoV-2: Small Molecule Inhibitors-The Current Status by Beeraka, Narasimha M, Sadhu, Surya P, Madhunapantula, SubbaRao V, Rao Pragada, Rajeswara, Svistunov, Andrey A, Nikolenko, Vladimir N, Mikhaleva, Liudmila M, Aliev, Gjumrakch

“…Severe Acute Respiratory Syndrome-Corona Virus-2 (SARS-CoV-2) induced Coronavirus Disease - 19 (COVID-19) cases have been increasing at an alarming rate (7.4…”
Get full text

A review of biological targets and therapeutic approaches in the management of triple-negative breast cancer by Kumar, Hitesh, Gupta, N Vishal, Jain, Rupshee, Madhunapantula, SubbaRao V, Babu, C Saravana, Kesharwani, Siddharth S, Dey, Surajit, Jain, Vikas

“…Triple-negative breast cancer (TNBC) is a heterogeneous, aggressive phenotype of breast cancer with associated chemoresistance. The development of chemo- or…”
Get full text

The PTEN-AKT3 signaling cascade as a therapeutic target in melanoma by Madhunapantula, SubbaRao V., Robertson, Gavin P.

“…Summary Melanocytes undergo extensive genetic changes during transformation into aggressive melanomas. These changes deregulate genes whose aberrant activity…”
Get full text

Comparative assessment of cognitive impairment and oxidative stress markers among vitamin D insufficient elderly patients with and without type 2 diabetes mellitus (T2DM) by R, Rajalakshmi, Uthaiah, Chinnappa A, C M, Ramya, Madhunapantula, SubbaRao V, Salimath, Paramahans V, K, Praveen, M, Srinath K, M R, Kishor

“…Disorders of mental health are known to affect cognitive functions, hence called as cognitive disorders. Impaired glucose metabolism, insulin resistance,…”
Get full text

Treatment With Naringenin Elevates the Activity of Transcription Factor Nrf2 to Protect Pancreatic β-Cells From Streptozotocin-Induced Diabetes in vitro and in vivo by Rajappa, Rashmi, Sireesh, Dornadula, Salai, Magesh B, Ramkumar, Kunka M, Sarvajayakesavulu, Suryanarayanan, Madhunapantula, SubbaRao V

“…Chronic hyperglycemia and unusually high oxidative stress are the key contributors for diabetes in humans. Since nuclear factor E2-related factor 2 (Nrf2)…”
Get full text

Mucosal vaccines: a paradigm shift in the development of mucosal adjuvants and delivery vehicles by Srivastava, Atul, Gowda, Devegowda Vishakante, Madhunapantula, SubbaRao V., Shinde, Chetan G., Iyer, Meenakshi

“…Mucosal immune responses are the first‐line defensive mechanisms against a variety of infections. Therefore, immunizations of mucosal surfaces from which…”
Get full text

Comparative Assessment of Vitamin-B12, Folic Acid and Homocysteine Levels in Relation to p53 Expression in Megaloblastic Anemia by Yadav, Manish K, Manoli, Nandini M, Madhunapantula, SubbaRao V

“…Megaloblastic anemia (MBA), also known as macrocytic anemia, is a type of anemia characterized by decreased number of RBCs as well as the presence of unusually…”
Get full text

Pigmented Microbial Extract (PMB) from Exiguobacterium Species MB2 Strain (PMB1) and Bacillus subtilis Strain MB1 (PMB2) Inhibited Breast Cancer Cells Growth In Vivo and In Vitro by Bandi, Deepa R, Chitturi, Ch M Kumari, Aswathanarayan, Jamuna Bai, Veeresh, Prashant Kumar M, Bovilla, Venugopal R, Sukocheva, Olga A, Devi, Potireddy Suvarnalatha, Natraj, Suma M, Madhunapantula, SubbaRao V

“…Breast cancer (BC) continues to be one of the major causes of cancer deaths in women. Progress has been made in targeting hormone and growth factor…”
Get full text

Anti-Proliferative Potential of Quercetin Loaded Polymeric Mixed Micelles on Rat C6 and Human U87MG Glioma Cells by Paranthaman, Sathishbabu, Uthaiah, Chinnappa A, Osmani, Riyaz Ali M, Hani, Umme, Ghazwani, Mohammed, Alamri, Ali H, Fatease, Adel Al, Madhunapantula, SubbaRao V, Gowda, Devegowda Vishkante

“…Quercetin (Qu) is a natural flavonoid present in many commonly consumed food items and is also identified as a potential anticancer agent. The present study…”
Get full text

The Role of Tumor Associated Macrophages (TAMs) in Cancer Progression, Chemoresistance, Angiogenesis and Metastasis - Current Status by Dallavalasa, Siva, Beeraka, Narasimha M, Basavaraju, Chaithanya G, Tulimilli, SubbaRao V, Sadhu, Surya Prabha, Rajesh, Konathala, Aliev, Gjumrakch, Madhunapantula, SubbaRao V

“…Tumor associated macrophages (TAMs), located in the tumor microenvironment (TME), play a significant role in cancer cell survival and progression. TAMs have…”
Get more information

Simultaneous targeting of COX-2 and AKT using selenocoxib-1-GSH to inhibit melanoma by Gowda, Raghavendra, Madhunapantula, Subbarao V, Desai, Dhimant, Amin, Shantu, Robertson, Gavin P

“…Melanoma is a highly metastatic and deadly disease. An agent simultaneously targeting the COX-2, PI3K/Akt, and mitogen-activated protein kinase (MAPK)…”
Get full text

The Akt signaling pathway: An emerging therapeutic target in malignant melanoma by Madhunapantula, SubbaRao V., Mosca, Paul J., Robertson, Gavin P.

“…Studies using cultured melanoma cells and patient tumor biopsies have demonstrated deregulated PI3 kinase-Akt3 pathway activity in ~70% of melanomas…”
Get full text

Quality by Design Based Formulation of Xanthohumol Loaded Solid Lipid Nanoparticles with Improved Bioavailability and Anticancer Effect against PC-3 Cells by Harish, Vancha, Tewari, Devesh, Mohd, Sharfuddin, Govindaiah, Pilli, Babu, Malakapogu Ravindra, Kumar, Rajesh, Gulati, Monica, Gowthamarajan, Kuppusamy, Madhunapantula, SubbaRao V, Chellappan, Dinesh Kumar, Gupta, Gaurav, Dua, Kamal, Dallavalasa, Siva, Singh, Sachin Kumar

“…Many natural products with greater therapeutic efficacy are limited to target several chronic diseases such as cancer, diabetes, and neurodegenerative…”
Get full text